eIF3: a factor for human health and disease

Detalhes bibliográficos
Autor(a) principal: Gomes-Duarte, Andreia
Data de Publicação: 2017
Outros Autores: Lacerda, Rafaela, Menezes, Juliane, Romão, Luísa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/5110
Resumo: The eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal recycling. Accordingly, deregulated eIF3 expression is associated with different pathological conditions, including cancer. In this manuscript, we discuss the interactome and function of each subunit of the human eIF3 complex. Furthermore, we review how altered levels of eIF3 subunits correlate with neurodegenerative disorders and cancer onset and development; in addition, we evaluate how such misregulation may also trigger infection cascades. A deep understanding of the molecular mechanisms underlying eIF3 role in human disease is essential to develop new eIF3-targeted therapeutic approaches and thus, overcome such conditions.
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spelling eIF3: a factor for human health and diseaseCancereIF3InfectionNeurodegenerative DiseaseTranslationTranslation Initiation FactorTranslational ControlExpressão GénicaGenómica Funcional e EstruturalThe eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal recycling. Accordingly, deregulated eIF3 expression is associated with different pathological conditions, including cancer. In this manuscript, we discuss the interactome and function of each subunit of the human eIF3 complex. Furthermore, we review how altered levels of eIF3 subunits correlate with neurodegenerative disorders and cancer onset and development; in addition, we evaluate how such misregulation may also trigger infection cascades. A deep understanding of the molecular mechanisms underlying eIF3 role in human disease is essential to develop new eIF3-targeted therapeutic approaches and thus, overcome such conditions.This work was partially supported by Fundação para a Ciência e a Tecnologia (UID/MULTI/04046/2013 to BioISI from FCT/MCTES/PIDDAC and PTFC/BIM-MEC/3749/2014 to LR). JM is supported by a fellowship from Fundação para a Ciência e a Tecnologia (SFRH/BPD/98360/2013). RL is a fellow from Fundação para a Ciência e a Tecnologia through the PTDC/BIMONC/4890/2014 project.Taylor & FrancisRepositório Científico do Instituto Nacional de SaúdeGomes-Duarte, AndreiaLacerda, RafaelaMenezes, JulianeRomão, Luísa2018-11-18T01:30:13Z2017-11-032017-11-03T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/5110engRNA Biol. 2018 Jan 2;15(1):26-34. doi: 10.1080/15476286.2017.1391437. Epub 2017 Nov 131547-628610.1080/15476286.2017.1391437info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:40Zoai:repositorio.insa.pt:10400.18/5110Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:49.911519Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv eIF3: a factor for human health and disease
title eIF3: a factor for human health and disease
spellingShingle eIF3: a factor for human health and disease
Gomes-Duarte, Andreia
Cancer
eIF3
Infection
Neurodegenerative Disease
Translation
Translation Initiation Factor
Translational Control
Expressão Génica
Genómica Funcional e Estrutural
title_short eIF3: a factor for human health and disease
title_full eIF3: a factor for human health and disease
title_fullStr eIF3: a factor for human health and disease
title_full_unstemmed eIF3: a factor for human health and disease
title_sort eIF3: a factor for human health and disease
author Gomes-Duarte, Andreia
author_facet Gomes-Duarte, Andreia
Lacerda, Rafaela
Menezes, Juliane
Romão, Luísa
author_role author
author2 Lacerda, Rafaela
Menezes, Juliane
Romão, Luísa
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Gomes-Duarte, Andreia
Lacerda, Rafaela
Menezes, Juliane
Romão, Luísa
dc.subject.por.fl_str_mv Cancer
eIF3
Infection
Neurodegenerative Disease
Translation
Translation Initiation Factor
Translational Control
Expressão Génica
Genómica Funcional e Estrutural
topic Cancer
eIF3
Infection
Neurodegenerative Disease
Translation
Translation Initiation Factor
Translational Control
Expressão Génica
Genómica Funcional e Estrutural
description The eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal recycling. Accordingly, deregulated eIF3 expression is associated with different pathological conditions, including cancer. In this manuscript, we discuss the interactome and function of each subunit of the human eIF3 complex. Furthermore, we review how altered levels of eIF3 subunits correlate with neurodegenerative disorders and cancer onset and development; in addition, we evaluate how such misregulation may also trigger infection cascades. A deep understanding of the molecular mechanisms underlying eIF3 role in human disease is essential to develop new eIF3-targeted therapeutic approaches and thus, overcome such conditions.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-03
2017-11-03T00:00:00Z
2018-11-18T01:30:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/5110
url http://hdl.handle.net/10400.18/5110
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv RNA Biol. 2018 Jan 2;15(1):26-34. doi: 10.1080/15476286.2017.1391437. Epub 2017 Nov 13
1547-6286
10.1080/15476286.2017.1391437
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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