Discontinuation of chronic benzodiazepine use in primary care

Detalhes bibliográficos
Autor(a) principal: Fernandes, Milene
Data de Publicação: 2022
Outros Autores: Neves, Inês, Oliveira, Joana, Santos, Osvaldo, Aguiar, Pedro, Atalaia, Paula, Matos, Fátima, Freitas, Carina, Alvim, António, Maria, Vasco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/155558
Resumo: Publisher Copyright: © 2021 The Author(s). Erratum: Correction to: Discontinuation of chronic benzodiazepine use in primary care: a nonrandomized intervention (Family Practice. 2022;39(2):241-248). Family Practice. 2022.39(3):563. (WOS: 000788675100001), (PMID:35485949), (Scopus ID: 85131225556).
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spelling Discontinuation of chronic benzodiazepine use in primary carea nonrandomized interventionbenzodiazepinesdeprescribingdiscontinuation protocolprimary healthcaresubstance usewithdrawal symptomsMedicine(all)SDG 3 - Good Health and Well-beingPublisher Copyright: © 2021 The Author(s). Erratum: Correction to: Discontinuation of chronic benzodiazepine use in primary care: a nonrandomized intervention (Family Practice. 2022;39(2):241-248). Family Practice. 2022.39(3):563. (WOS: 000788675100001), (PMID:35485949), (Scopus ID: 85131225556).Background: Chronic benzodiazepine use is a challenge in primary care practice. Protocols to support safe discontinuation are still needed, especially in countries with high utilization rates. Objectives: To evaluate the feasibility, effectiveness, and safety of a benzodiazepine discontinuation protocol in primary care setting. Methods: Nonrandomized, single-arm interventional study, at primary care units. Family physicians (FPs) recruited patients (18-85 years-old) with benzodiazepine dependence and chronic daily use ≥3 months. Patients with daily dosages ≥30 mg diazepam-equivalent, taking zolpidem, with a history of other substance abuse or major psychiatric disease were excluded. After the switch to diazepam, the dosage was gradually tapered according to a standardized protocol. Primary endpoint was the percentage of patients who stopped benzodiazepine at the intervention last visit. Dosage reduction, withdrawal symptoms, patients' and FPs' satisfaction with the protocol were evaluated. Results: From 66 enrolled patients (74% female; 66.7% aged >64 years; median time of benzodiazepine use was 120 months), 2 withdrew due to medical reasons and 3 presented protocol deviations. Overall, 59.4% of participants successfully stopped benzodiazepine (60.7% when excluding protocol deviations). Men had higher probability of success (relative risk = 0.51, P = 0.001). A total of 31 patients reported at least 1 withdrawal symptom, most frequently insomnia and anxiety. Most of participating FP considered the clinical protocol useful and feasible in daily practice. Among patients completing the protocol, 77% were satisfied. For the patients who reduced dosage, 85% kept without benzodiazepines after 12 months. Conclusion: The discontinuation protocol with standardized dosage reduction was feasible at primary care and showed long-term effectiveness.Escola Nacional de Saúde Pública (ENSP)Comprehensive Health Research Centre (CHRC) - Pólo ENSPCentro de Investigação em Saúde Pública (CISP/PHRC)RUNFernandes, MileneNeves, InêsOliveira, JoanaSantos, OsvaldoAguiar, PedroAtalaia, PaulaMatos, FátimaFreitas, CarinaAlvim, AntónioMaria, Vasco2023-07-19T22:16:13Z2022-04-012022-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfapplication/pdfhttp://hdl.handle.net/10362/155558eng0263-2136PURE: 66759484https://doi.org/10.1093/fampra/cmab143info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:38:11Zoai:run.unl.pt:10362/155558Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:56:07.792117Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Discontinuation of chronic benzodiazepine use in primary care
a nonrandomized intervention
title Discontinuation of chronic benzodiazepine use in primary care
spellingShingle Discontinuation of chronic benzodiazepine use in primary care
Fernandes, Milene
benzodiazepines
deprescribing
discontinuation protocol
primary healthcare
substance use
withdrawal symptoms
Medicine(all)
SDG 3 - Good Health and Well-being
title_short Discontinuation of chronic benzodiazepine use in primary care
title_full Discontinuation of chronic benzodiazepine use in primary care
title_fullStr Discontinuation of chronic benzodiazepine use in primary care
title_full_unstemmed Discontinuation of chronic benzodiazepine use in primary care
title_sort Discontinuation of chronic benzodiazepine use in primary care
author Fernandes, Milene
author_facet Fernandes, Milene
Neves, Inês
Oliveira, Joana
Santos, Osvaldo
Aguiar, Pedro
Atalaia, Paula
Matos, Fátima
Freitas, Carina
Alvim, António
Maria, Vasco
author_role author
author2 Neves, Inês
Oliveira, Joana
Santos, Osvaldo
Aguiar, Pedro
Atalaia, Paula
Matos, Fátima
Freitas, Carina
Alvim, António
Maria, Vasco
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Escola Nacional de Saúde Pública (ENSP)
Comprehensive Health Research Centre (CHRC) - Pólo ENSP
Centro de Investigação em Saúde Pública (CISP/PHRC)
RUN
dc.contributor.author.fl_str_mv Fernandes, Milene
Neves, Inês
Oliveira, Joana
Santos, Osvaldo
Aguiar, Pedro
Atalaia, Paula
Matos, Fátima
Freitas, Carina
Alvim, António
Maria, Vasco
dc.subject.por.fl_str_mv benzodiazepines
deprescribing
discontinuation protocol
primary healthcare
substance use
withdrawal symptoms
Medicine(all)
SDG 3 - Good Health and Well-being
topic benzodiazepines
deprescribing
discontinuation protocol
primary healthcare
substance use
withdrawal symptoms
Medicine(all)
SDG 3 - Good Health and Well-being
description Publisher Copyright: © 2021 The Author(s). Erratum: Correction to: Discontinuation of chronic benzodiazepine use in primary care: a nonrandomized intervention (Family Practice. 2022;39(2):241-248). Family Practice. 2022.39(3):563. (WOS: 000788675100001), (PMID:35485949), (Scopus ID: 85131225556).
publishDate 2022
dc.date.none.fl_str_mv 2022-04-01
2022-04-01T00:00:00Z
2023-07-19T22:16:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/155558
url http://hdl.handle.net/10362/155558
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0263-2136
PURE: 66759484
https://doi.org/10.1093/fampra/cmab143
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
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application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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