Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Diogo
Data de Publicação: 2020
Outros Autores: Nunes, Ana Rita, Teles, Magda C, Anbalagan, Savani, Blechman, Janna, Levkowitz, Gil, Oliveira, Rui Filipe
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.12/7821
Resumo: Oxytocin-like peptides have been implicated in the regulation of a wide range of social behaviors across taxa. On the other hand, the social environment, which is composed of conspecifics that may vary in their genotypes, also influences social behavior, creating the possibility for indirect genetic effects. Here, we used a zebrafish oxytocin receptor knockout line to investigate how the genotypic composition of the social environment (Gs) interacts with the oxytocin genotype of the focal individual (Gi) in the regulation of its social behavior. For this purpose, we have raised wild-type or knock-out zebrafish in either wild-type or knock-out shoals and tested different components of social behavior in adults. GixGs effects were detected in some behaviors, highlighting the need to control for GixGs effects when interpreting results of experiments using genetically modified animals, since the genotypic composition of the social environment can either rescue or promote phenotypes associated with specific genes.
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spelling Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafishOxytocin-like peptides have been implicated in the regulation of a wide range of social behaviors across taxa. On the other hand, the social environment, which is composed of conspecifics that may vary in their genotypes, also influences social behavior, creating the possibility for indirect genetic effects. Here, we used a zebrafish oxytocin receptor knockout line to investigate how the genotypic composition of the social environment (Gs) interacts with the oxytocin genotype of the focal individual (Gi) in the regulation of its social behavior. For this purpose, we have raised wild-type or knock-out zebrafish in either wild-type or knock-out shoals and tested different components of social behavior in adults. GixGs effects were detected in some behaviors, highlighting the need to control for GixGs effects when interpreting results of experiments using genetically modified animals, since the genotypic composition of the social environment can either rescue or promote phenotypes associated with specific genes.Fundação para a Ciência e Tecnologia - FCTeLife Sciences PublicationsRepositório do ISPARibeiro, DiogoNunes, Ana RitaTeles, Magda CAnbalagan, SavaniBlechman, JannaLevkowitz, GilOliveira, Rui Filipe2020-11-06T12:42:19Z2020-01-01T00:00:00Z2020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.12/7821engeLife, 9, 1-10 Doi: 10.7554/eLife.569732050084X10.7554/eLife.56973info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-05T16:43:34Zoai:repositorio.ispa.pt:10400.12/7821Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:25:40.107096Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish
title Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish
spellingShingle Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish
Ribeiro, Diogo
title_short Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish
title_full Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish
title_fullStr Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish
title_full_unstemmed Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish
title_sort Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish
author Ribeiro, Diogo
author_facet Ribeiro, Diogo
Nunes, Ana Rita
Teles, Magda C
Anbalagan, Savani
Blechman, Janna
Levkowitz, Gil
Oliveira, Rui Filipe
author_role author
author2 Nunes, Ana Rita
Teles, Magda C
Anbalagan, Savani
Blechman, Janna
Levkowitz, Gil
Oliveira, Rui Filipe
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do ISPA
dc.contributor.author.fl_str_mv Ribeiro, Diogo
Nunes, Ana Rita
Teles, Magda C
Anbalagan, Savani
Blechman, Janna
Levkowitz, Gil
Oliveira, Rui Filipe
description Oxytocin-like peptides have been implicated in the regulation of a wide range of social behaviors across taxa. On the other hand, the social environment, which is composed of conspecifics that may vary in their genotypes, also influences social behavior, creating the possibility for indirect genetic effects. Here, we used a zebrafish oxytocin receptor knockout line to investigate how the genotypic composition of the social environment (Gs) interacts with the oxytocin genotype of the focal individual (Gi) in the regulation of its social behavior. For this purpose, we have raised wild-type or knock-out zebrafish in either wild-type or knock-out shoals and tested different components of social behavior in adults. GixGs effects were detected in some behaviors, highlighting the need to control for GixGs effects when interpreting results of experiments using genetically modified animals, since the genotypic composition of the social environment can either rescue or promote phenotypes associated with specific genes.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-06T12:42:19Z
2020-01-01T00:00:00Z
2020-01-01T00:00:00Z
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language eng
dc.relation.none.fl_str_mv eLife, 9, 1-10 Doi: 10.7554/eLife.56973
2050084X
10.7554/eLife.56973
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publisher.none.fl_str_mv eLife Sciences Publications
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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