Therapeutic Plasmapheresis: Seven Year Experience of an Intensive Care Unit in Portugal
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14266 |
Resumo: | Introduction: Therapeutic plasmapheresis is a therapeutic procedure in which the patient’s blood is passed through a medical device which separates out plasma from other components of blood. The plasma is removed and replaced with a replacement solution. Studies on the use of plasmapheresis in critically ill patients are scarce. The aim of this study was to review all therapeutic plasmapheresis sessions carried out in the Hospital Beatriz Ângelo intensive care unit.Material and Methods: An observational retrospective study was conducted between April 2012 and March 2019. All patients who underwent therapeutic plasmapheresis in the intensive care unit were included, and plasmapheresis sessions held outside the intensive care unit were excluded.Results: Of 46 patients, 63% were men (n = 29), with a median age of 53 years. The most frequent diagnoses were hypertriglyceridemia-induced pancreatitis, vasculitis, autoimmune haemolytic anaemia, and atypical haemolytic-uremic syndrome. A total of 198 plasmapheresis sessions were carried out in the intensive care unit. Most of the used replacement solutions were fresh frozen plasma (34.4%), albumin/crystalloid (24.2%), and albumin/fresh frozen plasma (19.2%). The most common complications were hydroelectrolytic changes (84; 42.4%) and coagulation disorders/thrombocytopenia (65; 32.8%). There was no need to interrupt any plasmapheresis session due to complications related to the patient.Conclusion: Therapeutic plasmapheresis is a complex technique that requires specific training. The indications are diverse, and some are not consensual. Complications were frequent, but they did not increase morbidity. |
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Therapeutic Plasmapheresis: Seven Year Experience of an Intensive Care Unit in PortugalPlasmaferese Terapêutica: Experiência de Sete Anos de um Serviço de Medicina Intensiva em PortugalCritical Illness/therapyPlasma Exchange/methodsPlasmapheresis/adverse effectsPlasmapheresis/methodsPlasmapheresis /therapeutic useEstado Crítico/tratamentoPlasmafere/efeitos adversosPlasmafere/métodosPlasmafere/uso terapêuticoTroca Plasmática/métodosIntroduction: Therapeutic plasmapheresis is a therapeutic procedure in which the patient’s blood is passed through a medical device which separates out plasma from other components of blood. The plasma is removed and replaced with a replacement solution. Studies on the use of plasmapheresis in critically ill patients are scarce. The aim of this study was to review all therapeutic plasmapheresis sessions carried out in the Hospital Beatriz Ângelo intensive care unit.Material and Methods: An observational retrospective study was conducted between April 2012 and March 2019. All patients who underwent therapeutic plasmapheresis in the intensive care unit were included, and plasmapheresis sessions held outside the intensive care unit were excluded.Results: Of 46 patients, 63% were men (n = 29), with a median age of 53 years. The most frequent diagnoses were hypertriglyceridemia-induced pancreatitis, vasculitis, autoimmune haemolytic anaemia, and atypical haemolytic-uremic syndrome. A total of 198 plasmapheresis sessions were carried out in the intensive care unit. Most of the used replacement solutions were fresh frozen plasma (34.4%), albumin/crystalloid (24.2%), and albumin/fresh frozen plasma (19.2%). The most common complications were hydroelectrolytic changes (84; 42.4%) and coagulation disorders/thrombocytopenia (65; 32.8%). There was no need to interrupt any plasmapheresis session due to complications related to the patient.Conclusion: Therapeutic plasmapheresis is a complex technique that requires specific training. The indications are diverse, and some are not consensual. Complications were frequent, but they did not increase morbidity.Introdução: A plasmaferese terapêutica é um procedimento em que o sangue passa por um circuito extracorpóreo que separa o plasma dos outros componentes do sangue. O plasma removido é substituído por soluções de reposição. Os estudos sobre a utilização de plasmaferese terapêutica no doente crítico são escassos. O objetivo do estudo foi rever todas as sessões de plasmaferese realizadas no serviço de Medicina Intensiva do Hospital Beatriz Ângelo.Material e Métodos: Estudo observacional retrospetivo de todos os doentes admitidos no serviço de Medicina Intensiva entre abril de 2012 e março de 2019. Foram selecionados os doentes submetidos a plasmaferese e excluídas as sessões realizadas fora do serviço de Medicina Intensiva.Resultados: No período de estudo foram incluídos 46 doentes. A maioria eram homens (n = 29; 63%) com uma idade mediana de 53 anos. Os diagnósticos mais frequentes foram pancreatite secundária a hipertrigliceridemia, vasculite, anemia hemolítica autoimune e síndrome hemolítica urémica atípica. Foram realizadas 198 sessões de plasmaferese no serviço de Medicina Intensiva. As soluções de substituição mais utilizadas foram plasma fresco congelado (34,4%), albumina/cristalóide (24,2%) e albumina/plasma (19,2%). As complicações mais comuns foram alterações hidroeletrolíticas (84; 42,4%), e distúrbios da coagulação/plaquetas (65; 32,8%). Emnenhum dos casos a técnica teve que ser interrompida por complicações relacionadas com o doente.Conclusão: A plasmafere terapêutica é uma técnica complexa que requer treino específico. As indicações são diversas e algumas não consensuais. As complicações foram frequentes, mas não condicionaram morbilidade associada.Ordem dos Médicos2022-03-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14266oai:ojs.www.actamedicaportuguesa.com:article/14266Acta Médica Portuguesa; Vol. 35 No. 3 (2022): March; 176-183Acta Médica Portuguesa; Vol. 35 N.º 3 (2022): Março; 176-1831646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14266https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14266/6415Direitos de Autor (c) 2021 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessFaria, RitaBucur, AlexeiGordinho, AndréFalcão, LuisCarrão, AndréFernandes, SaraColaço, João PedroMeneses-Oliveira, CarlosMessias, António2022-12-20T11:07:10Zoai:ojs.www.actamedicaportuguesa.com:article/14266Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:20:27.351746Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Therapeutic Plasmapheresis: Seven Year Experience of an Intensive Care Unit in Portugal Plasmaferese Terapêutica: Experiência de Sete Anos de um Serviço de Medicina Intensiva em Portugal |
title |
Therapeutic Plasmapheresis: Seven Year Experience of an Intensive Care Unit in Portugal |
spellingShingle |
Therapeutic Plasmapheresis: Seven Year Experience of an Intensive Care Unit in Portugal Faria, Rita Critical Illness/therapy Plasma Exchange/methods Plasmapheresis/adverse effects Plasmapheresis/methods Plasmapheresis /therapeutic use Estado Crítico/tratamento Plasmafere/efeitos adversos Plasmafere/métodos Plasmafere/uso terapêutico Troca Plasmática/métodos |
title_short |
Therapeutic Plasmapheresis: Seven Year Experience of an Intensive Care Unit in Portugal |
title_full |
Therapeutic Plasmapheresis: Seven Year Experience of an Intensive Care Unit in Portugal |
title_fullStr |
Therapeutic Plasmapheresis: Seven Year Experience of an Intensive Care Unit in Portugal |
title_full_unstemmed |
Therapeutic Plasmapheresis: Seven Year Experience of an Intensive Care Unit in Portugal |
title_sort |
Therapeutic Plasmapheresis: Seven Year Experience of an Intensive Care Unit in Portugal |
author |
Faria, Rita |
author_facet |
Faria, Rita Bucur, Alexei Gordinho, André Falcão, Luis Carrão, André Fernandes, Sara Colaço, João Pedro Meneses-Oliveira, Carlos Messias, António |
author_role |
author |
author2 |
Bucur, Alexei Gordinho, André Falcão, Luis Carrão, André Fernandes, Sara Colaço, João Pedro Meneses-Oliveira, Carlos Messias, António |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Faria, Rita Bucur, Alexei Gordinho, André Falcão, Luis Carrão, André Fernandes, Sara Colaço, João Pedro Meneses-Oliveira, Carlos Messias, António |
dc.subject.por.fl_str_mv |
Critical Illness/therapy Plasma Exchange/methods Plasmapheresis/adverse effects Plasmapheresis/methods Plasmapheresis /therapeutic use Estado Crítico/tratamento Plasmafere/efeitos adversos Plasmafere/métodos Plasmafere/uso terapêutico Troca Plasmática/métodos |
topic |
Critical Illness/therapy Plasma Exchange/methods Plasmapheresis/adverse effects Plasmapheresis/methods Plasmapheresis /therapeutic use Estado Crítico/tratamento Plasmafere/efeitos adversos Plasmafere/métodos Plasmafere/uso terapêutico Troca Plasmática/métodos |
description |
Introduction: Therapeutic plasmapheresis is a therapeutic procedure in which the patient’s blood is passed through a medical device which separates out plasma from other components of blood. The plasma is removed and replaced with a replacement solution. Studies on the use of plasmapheresis in critically ill patients are scarce. The aim of this study was to review all therapeutic plasmapheresis sessions carried out in the Hospital Beatriz Ângelo intensive care unit.Material and Methods: An observational retrospective study was conducted between April 2012 and March 2019. All patients who underwent therapeutic plasmapheresis in the intensive care unit were included, and plasmapheresis sessions held outside the intensive care unit were excluded.Results: Of 46 patients, 63% were men (n = 29), with a median age of 53 years. The most frequent diagnoses were hypertriglyceridemia-induced pancreatitis, vasculitis, autoimmune haemolytic anaemia, and atypical haemolytic-uremic syndrome. A total of 198 plasmapheresis sessions were carried out in the intensive care unit. Most of the used replacement solutions were fresh frozen plasma (34.4%), albumin/crystalloid (24.2%), and albumin/fresh frozen plasma (19.2%). The most common complications were hydroelectrolytic changes (84; 42.4%) and coagulation disorders/thrombocytopenia (65; 32.8%). There was no need to interrupt any plasmapheresis session due to complications related to the patient.Conclusion: Therapeutic plasmapheresis is a complex technique that requires specific training. The indications are diverse, and some are not consensual. Complications were frequent, but they did not increase morbidity. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14266 oai:ojs.www.actamedicaportuguesa.com:article/14266 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14266 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/14266 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14266 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14266/6415 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2021 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2021 Acta Médica Portuguesa |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 35 No. 3 (2022): March; 176-183 Acta Médica Portuguesa; Vol. 35 N.º 3 (2022): Março; 176-183 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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