An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine

Detalhes bibliográficos
Autor(a) principal: Silva, Simone Santos
Data de Publicação: 2013
Outros Autores: Popa, Elena Geta, Gomes, Manuela E., Cerqueira, M. T., Marques, A. P., Caridade, S. G., Teixeira, P., Sousa, Cláudia, Mano, J. F., Reis, R. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/23718
Resumo: A significant number of therapeutics derived from natural polymers and plants have been developed to replace or to be used in conjunction with existing dressing products. The use of the therapeutic properties of aloe vera could be very useful in the creation of active wound dressing materials. The present work was undertaken to examine issues concerning structural features, topography, enzymatic degradation behavior, antibacterial activity and cellular response of chitosan/aloe vera-based membranes. The chitosan/aloe vera-based membranes that were developed displayed satisfactory degradation, roughness, wettability and mechanical properties. A higher antibacterial potency was displayed by the blended membranes. Moreover, in vitro assays demonstrated that these blended membranes have good cell compatibility with primary human dermal fibroblasts. The chitosan/aloe vera-based membranes might be promising wound dressing materials.
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spelling An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicineAloe veraChitosanWound dressingAloe vera gelWound dressingsDermal fibroblastsMembraneScience & TechnologyA significant number of therapeutics derived from natural polymers and plants have been developed to replace or to be used in conjunction with existing dressing products. The use of the therapeutic properties of aloe vera could be very useful in the creation of active wound dressing materials. The present work was undertaken to examine issues concerning structural features, topography, enzymatic degradation behavior, antibacterial activity and cellular response of chitosan/aloe vera-based membranes. The chitosan/aloe vera-based membranes that were developed displayed satisfactory degradation, roughness, wettability and mechanical properties. A higher antibacterial potency was displayed by the blended membranes. Moreover, in vitro assays demonstrated that these blended membranes have good cell compatibility with primary human dermal fibroblasts. The chitosan/aloe vera-based membranes might be promising wound dressing materials.The authors acknowledge financial support from the Portuguese Foundation for Science and Technology (grants SFRH/BPD/45307/2008 and SFRH/BD/64601/2009), the "Fundo Social Europeu", and the "Programa Diferencial de Potencial Humano". This work was partially supported by the FEDER through POCTEP 0330_IBEROMARE_1_P.ElsevierUniversidade do MinhoSilva, Simone SantosPopa, Elena GetaGomes, Manuela E.Cerqueira, M. T.Marques, A. P.Caridade, S. G.Teixeira, P.Sousa, CláudiaMano, J. F.Reis, R. L.2013-062013-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/23718eng1742-706110.1016/j.actbio.2013.02.02723462554http://dx.doi.org/10.1016/j.actbio.2013.02.027info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T07:37:12Zoai:repositorium.sdum.uminho.pt:1822/23718Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T07:37:12Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine
title An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine
spellingShingle An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine
Silva, Simone Santos
Aloe vera
Chitosan
Wound dressing
Aloe vera gel
Wound dressings
Dermal fibroblasts
Membrane
Science & Technology
title_short An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine
title_full An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine
title_fullStr An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine
title_full_unstemmed An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine
title_sort An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine
author Silva, Simone Santos
author_facet Silva, Simone Santos
Popa, Elena Geta
Gomes, Manuela E.
Cerqueira, M. T.
Marques, A. P.
Caridade, S. G.
Teixeira, P.
Sousa, Cláudia
Mano, J. F.
Reis, R. L.
author_role author
author2 Popa, Elena Geta
Gomes, Manuela E.
Cerqueira, M. T.
Marques, A. P.
Caridade, S. G.
Teixeira, P.
Sousa, Cláudia
Mano, J. F.
Reis, R. L.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Silva, Simone Santos
Popa, Elena Geta
Gomes, Manuela E.
Cerqueira, M. T.
Marques, A. P.
Caridade, S. G.
Teixeira, P.
Sousa, Cláudia
Mano, J. F.
Reis, R. L.
dc.subject.por.fl_str_mv Aloe vera
Chitosan
Wound dressing
Aloe vera gel
Wound dressings
Dermal fibroblasts
Membrane
Science & Technology
topic Aloe vera
Chitosan
Wound dressing
Aloe vera gel
Wound dressings
Dermal fibroblasts
Membrane
Science & Technology
description A significant number of therapeutics derived from natural polymers and plants have been developed to replace or to be used in conjunction with existing dressing products. The use of the therapeutic properties of aloe vera could be very useful in the creation of active wound dressing materials. The present work was undertaken to examine issues concerning structural features, topography, enzymatic degradation behavior, antibacterial activity and cellular response of chitosan/aloe vera-based membranes. The chitosan/aloe vera-based membranes that were developed displayed satisfactory degradation, roughness, wettability and mechanical properties. A higher antibacterial potency was displayed by the blended membranes. Moreover, in vitro assays demonstrated that these blended membranes have good cell compatibility with primary human dermal fibroblasts. The chitosan/aloe vera-based membranes might be promising wound dressing materials.
publishDate 2013
dc.date.none.fl_str_mv 2013-06
2013-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/23718
url http://hdl.handle.net/1822/23718
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1742-7061
10.1016/j.actbio.2013.02.027
23462554
http://dx.doi.org/10.1016/j.actbio.2013.02.027
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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