An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/23718 |
Resumo: | A significant number of therapeutics derived from natural polymers and plants have been developed to replace or to be used in conjunction with existing dressing products. The use of the therapeutic properties of aloe vera could be very useful in the creation of active wound dressing materials. The present work was undertaken to examine issues concerning structural features, topography, enzymatic degradation behavior, antibacterial activity and cellular response of chitosan/aloe vera-based membranes. The chitosan/aloe vera-based membranes that were developed displayed satisfactory degradation, roughness, wettability and mechanical properties. A higher antibacterial potency was displayed by the blended membranes. Moreover, in vitro assays demonstrated that these blended membranes have good cell compatibility with primary human dermal fibroblasts. The chitosan/aloe vera-based membranes might be promising wound dressing materials. |
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An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicineAloe veraChitosanWound dressingAloe vera gelWound dressingsDermal fibroblastsMembraneScience & TechnologyA significant number of therapeutics derived from natural polymers and plants have been developed to replace or to be used in conjunction with existing dressing products. The use of the therapeutic properties of aloe vera could be very useful in the creation of active wound dressing materials. The present work was undertaken to examine issues concerning structural features, topography, enzymatic degradation behavior, antibacterial activity and cellular response of chitosan/aloe vera-based membranes. The chitosan/aloe vera-based membranes that were developed displayed satisfactory degradation, roughness, wettability and mechanical properties. A higher antibacterial potency was displayed by the blended membranes. Moreover, in vitro assays demonstrated that these blended membranes have good cell compatibility with primary human dermal fibroblasts. The chitosan/aloe vera-based membranes might be promising wound dressing materials.The authors acknowledge financial support from the Portuguese Foundation for Science and Technology (grants SFRH/BPD/45307/2008 and SFRH/BD/64601/2009), the "Fundo Social Europeu", and the "Programa Diferencial de Potencial Humano". This work was partially supported by the FEDER through POCTEP 0330_IBEROMARE_1_P.ElsevierUniversidade do MinhoSilva, Simone SantosPopa, Elena GetaGomes, Manuela E.Cerqueira, M. T.Marques, A. P.Caridade, S. G.Teixeira, P.Sousa, CláudiaMano, J. F.Reis, R. L.2013-062013-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/23718eng1742-706110.1016/j.actbio.2013.02.02723462554http://dx.doi.org/10.1016/j.actbio.2013.02.027info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T07:37:12Zoai:repositorium.sdum.uminho.pt:1822/23718Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T07:37:12Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine |
title |
An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine |
spellingShingle |
An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine Silva, Simone Santos Aloe vera Chitosan Wound dressing Aloe vera gel Wound dressings Dermal fibroblasts Membrane Science & Technology |
title_short |
An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine |
title_full |
An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine |
title_fullStr |
An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine |
title_full_unstemmed |
An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine |
title_sort |
An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine |
author |
Silva, Simone Santos |
author_facet |
Silva, Simone Santos Popa, Elena Geta Gomes, Manuela E. Cerqueira, M. T. Marques, A. P. Caridade, S. G. Teixeira, P. Sousa, Cláudia Mano, J. F. Reis, R. L. |
author_role |
author |
author2 |
Popa, Elena Geta Gomes, Manuela E. Cerqueira, M. T. Marques, A. P. Caridade, S. G. Teixeira, P. Sousa, Cláudia Mano, J. F. Reis, R. L. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Silva, Simone Santos Popa, Elena Geta Gomes, Manuela E. Cerqueira, M. T. Marques, A. P. Caridade, S. G. Teixeira, P. Sousa, Cláudia Mano, J. F. Reis, R. L. |
dc.subject.por.fl_str_mv |
Aloe vera Chitosan Wound dressing Aloe vera gel Wound dressings Dermal fibroblasts Membrane Science & Technology |
topic |
Aloe vera Chitosan Wound dressing Aloe vera gel Wound dressings Dermal fibroblasts Membrane Science & Technology |
description |
A significant number of therapeutics derived from natural polymers and plants have been developed to replace or to be used in conjunction with existing dressing products. The use of the therapeutic properties of aloe vera could be very useful in the creation of active wound dressing materials. The present work was undertaken to examine issues concerning structural features, topography, enzymatic degradation behavior, antibacterial activity and cellular response of chitosan/aloe vera-based membranes. The chitosan/aloe vera-based membranes that were developed displayed satisfactory degradation, roughness, wettability and mechanical properties. A higher antibacterial potency was displayed by the blended membranes. Moreover, in vitro assays demonstrated that these blended membranes have good cell compatibility with primary human dermal fibroblasts. The chitosan/aloe vera-based membranes might be promising wound dressing materials. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06 2013-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/23718 |
url |
http://hdl.handle.net/1822/23718 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1742-7061 10.1016/j.actbio.2013.02.027 23462554 http://dx.doi.org/10.1016/j.actbio.2013.02.027 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817545380741513216 |