Antitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifolius

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Daniel
Data de Publicação: 2015
Outros Autores: Alves, Celso, Horta, André, Pinteus, Susete, Silva, Joana, Culioli, Gérald, Thomas, Olivier P., Pedrosa, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/6084
Resumo: Acknowledgments : This work was supported through funding provided by the European Commission Collaborative Project FP7 number 265896-www.bammbo.eu). One of the authors (G.C.) was partially supported by CNRS (Côte d’Azur delegation-DR 20). J.-M. Guigonis from the Plate-Forme Bernard Rossi of Nice is acknowledged for recording HRMS spectra.
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spelling Antitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifoliusRed algaeSphaerococcusDiterpenesSphaeraneDactylomelaneHepG-2Pathogenic microorganismsAcknowledgments : This work was supported through funding provided by the European Commission Collaborative Project FP7 number 265896-www.bammbo.eu). One of the authors (G.C.) was partially supported by CNRS (Côte d’Azur delegation-DR 20). J.-M. Guigonis from the Plate-Forme Bernard Rossi of Nice is acknowledged for recording HRMS spectra.Cancer and infectious diseases continue to be a major public health problem, and new drugs are necessary. As marine organisms are well known to provide a wide range of original compounds, the aim of this study was to investigate the bioactivity of the main constituents of the cosmopolitan red alga, Sphaerococcus coronopifolius. The structure of several bromoditerpenes was determined by extensive spectroscopic analysis and comparison with literature data. Five molecules were isolated and characterized which include a new brominated diterpene belonging to the rare dactylomelane family and named sphaerodactylomelol (1), along with four already known sphaerane bromoditerpenes (2–5). Antitumor activity was assessed by cytotoxicity and anti-proliferative assays on an in vitro model of human hepatocellular carcinoma (HepG-2 cells). Antimicrobial activity was evaluated against four pathogenic microorganisms: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. Compound 4 exhibited the highest antimicrobial activity against S. aureus (IC50 6.35 μM) and compound 5 the highest anti-proliferative activity on HepG-2 cells (IC50 42.9 μM). The new diterpene, sphaerodactylomelol (1), induced inhibition of cell proliferation (IC50 280 μM) and cytotoxicity (IC50 720 μM) on HepG-2 cells and showed antimicrobial activity against S. aureus (IC50 96.3 μM).MDPIIC-OnlineRodrigues, DanielAlves, CelsoHorta, AndréPinteus, SuseteSilva, JoanaCulioli, GéraldThomas, Olivier P.Pedrosa, Rui2021-08-12T12:22:37Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/6084engRodrigues, D.; Alves, C.; Horta, A.; Pinteus, S.; Silva, J.; Culioli, G.; Thomas, O.P.; Pedrosa, R. Antitumor and Antimicrobial Potential of Bromoditerpenes Isolated from the Red Alga, Sphaerococcus coronopifolius. Mar. Drugs 2015, 13, 713-726. https://doi.org/10.3390/md130207131660-339710.3390/md13020713info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:52:21Zoai:iconline.ipleiria.pt:10400.8/6084Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:49:24.997366Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifolius
title Antitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifolius
spellingShingle Antitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifolius
Rodrigues, Daniel
Red algae
Sphaerococcus
Diterpenes
Sphaerane
Dactylomelane
HepG-2
Pathogenic microorganisms
title_short Antitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifolius
title_full Antitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifolius
title_fullStr Antitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifolius
title_full_unstemmed Antitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifolius
title_sort Antitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifolius
author Rodrigues, Daniel
author_facet Rodrigues, Daniel
Alves, Celso
Horta, André
Pinteus, Susete
Silva, Joana
Culioli, Gérald
Thomas, Olivier P.
Pedrosa, Rui
author_role author
author2 Alves, Celso
Horta, André
Pinteus, Susete
Silva, Joana
Culioli, Gérald
Thomas, Olivier P.
Pedrosa, Rui
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Rodrigues, Daniel
Alves, Celso
Horta, André
Pinteus, Susete
Silva, Joana
Culioli, Gérald
Thomas, Olivier P.
Pedrosa, Rui
dc.subject.por.fl_str_mv Red algae
Sphaerococcus
Diterpenes
Sphaerane
Dactylomelane
HepG-2
Pathogenic microorganisms
topic Red algae
Sphaerococcus
Diterpenes
Sphaerane
Dactylomelane
HepG-2
Pathogenic microorganisms
description Acknowledgments : This work was supported through funding provided by the European Commission Collaborative Project FP7 number 265896-www.bammbo.eu). One of the authors (G.C.) was partially supported by CNRS (Côte d’Azur delegation-DR 20). J.-M. Guigonis from the Plate-Forme Bernard Rossi of Nice is acknowledged for recording HRMS spectra.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2021-08-12T12:22:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/6084
url http://hdl.handle.net/10400.8/6084
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rodrigues, D.; Alves, C.; Horta, A.; Pinteus, S.; Silva, J.; Culioli, G.; Thomas, O.P.; Pedrosa, R. Antitumor and Antimicrobial Potential of Bromoditerpenes Isolated from the Red Alga, Sphaerococcus coronopifolius. Mar. Drugs 2015, 13, 713-726. https://doi.org/10.3390/md13020713
1660-3397
10.3390/md13020713
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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