Age‐related white matter hyperintensities and overactive bladder: a systematic review

Bibliographic Details
Main Author: Pereira E Silva, Ricardo
Publication Date: 2023
Other Authors: de Sousa, Diana Aguiar, Lopes, Filipe Abadesso, Silva‐Ramos, Miguel, Verdelho, Ana
Format: Article
Language: eng
Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full: http://hdl.handle.net/10451/56869
Summary: © 2023 The Authors. Neurourology and Urodynamics published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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spelling Age‐related white matter hyperintensities and overactive bladder: a systematic reviewAgingLeukoencephalopathiesLower urinary tract symptomsPatient reported outcome measuresUrinary bladderOveractiveUrinary incontinenceUrinary incontinenceUrge© 2023 The Authors. Neurourology and Urodynamics published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Introduction: Age-related white matter hyperintensities (ARWMHs) on brain magnetic resonance imaging have been associated with lower urinary tract symptoms/dysfunction (LUTS/LUTD), namely overactive bladder (OAB) and detrusor overactivity. We aimed to systematically review existing data on the association between ARWMH and LUTS and which clinical tools have been used for this assessment. Materials and methods: We searched PubMed/MEDLINE, Cochrane Library, and clinicaltrials.gov (from 1980 to November 2021) and considered original studies reporting data on ARWMH and LUTS/LUTD in patients of both sexes aged 50 or above. The primary outcome was OAB. We calculated the unadjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for the outcomes of interest using random-effects models. Results: Fourteen studies were included. LUTS assessment was heterogeneous and mainly based on the use of nonvalidated questionnaires. Urodynamics assessment was reported in five studies. ARWMHs were graded using visual scales in eight studies. Patients with moderate-to-severe ARWMHs were more likely to present with OAB and urgency urinary incontinence (UUI; OR = 1.61; 95% CI: 1.05-2.49, p = 0.03), I2 = 21.3%) when compared to patients with similar age and absent or mild ARWMH. Discussion and conclusions: High-quality data on the association between ARWMH and OAB is scarce. Patients with moderate to severe ARWMH showed higher levels of OAB symptoms, including UUI, when compared to patients with absent or mild ARWMH. The use of standardized tools to assess both ARWMH and OAB in these patients should be encouraged in future research.WileyRepositório da Universidade de LisboaPereira E Silva, Ricardode Sousa, Diana AguiarLopes, Filipe AbadessoSilva‐Ramos, MiguelVerdelho, Ana2023-03-28T14:13:37Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56869engNeurourol Urodyn. 2023 Mar 270733-246710.1002/nau.251741520-6777info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:04:51Zoai:repositorio.ul.pt:10451/56869Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:23.911528Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Age‐related white matter hyperintensities and overactive bladder: a systematic review
title Age‐related white matter hyperintensities and overactive bladder: a systematic review
spellingShingle Age‐related white matter hyperintensities and overactive bladder: a systematic review
Pereira E Silva, Ricardo
Aging
Leukoencephalopathies
Lower urinary tract symptoms
Patient reported outcome measures
Urinary bladder
Overactive
Urinary incontinence
Urinary incontinence
Urge
title_short Age‐related white matter hyperintensities and overactive bladder: a systematic review
title_full Age‐related white matter hyperintensities and overactive bladder: a systematic review
title_fullStr Age‐related white matter hyperintensities and overactive bladder: a systematic review
title_full_unstemmed Age‐related white matter hyperintensities and overactive bladder: a systematic review
title_sort Age‐related white matter hyperintensities and overactive bladder: a systematic review
author Pereira E Silva, Ricardo
author_facet Pereira E Silva, Ricardo
de Sousa, Diana Aguiar
Lopes, Filipe Abadesso
Silva‐Ramos, Miguel
Verdelho, Ana
author_role author
author2 de Sousa, Diana Aguiar
Lopes, Filipe Abadesso
Silva‐Ramos, Miguel
Verdelho, Ana
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Pereira E Silva, Ricardo
de Sousa, Diana Aguiar
Lopes, Filipe Abadesso
Silva‐Ramos, Miguel
Verdelho, Ana
dc.subject.por.fl_str_mv Aging
Leukoencephalopathies
Lower urinary tract symptoms
Patient reported outcome measures
Urinary bladder
Overactive
Urinary incontinence
Urinary incontinence
Urge
topic Aging
Leukoencephalopathies
Lower urinary tract symptoms
Patient reported outcome measures
Urinary bladder
Overactive
Urinary incontinence
Urinary incontinence
Urge
description © 2023 The Authors. Neurourology and Urodynamics published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
publishDate 2023
dc.date.none.fl_str_mv 2023-03-28T14:13:37Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/56869
url http://hdl.handle.net/10451/56869
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Neurourol Urodyn. 2023 Mar 27
0733-2467
10.1002/nau.25174
1520-6777
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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