Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery

Detalhes bibliográficos
Autor(a) principal: Oliveira, Paula Alexandra
Data de Publicação: 2016
Outros Autores: Costa, Rui Gil da, Nóbrega, Carmen, Rodrigues, Regina Arantes, Leite, Rosário Pinto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.19/3587
Resumo: Urinary bladder cancer (UBC) is the second most frequent malignancy of the urinary system and the ninth most common cancer worldwide, affecting individuals over the age of 65. Several investigations have embarked on advancing knowledge of the mechanisms underlying urothelial carcinogenesis, understanding the mechanisms of antineoplastic drugs resistance and discovering new antineoplastic drugs. In vitro and in vivo models are crucial for providing additional insights into the mechanisms of urothelial carcinogenesis. With these models, various molecular pathways involved in urothelial carcinogenesis have been discovered, allowing therapeutic manipulation.
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spelling Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discoveryAnimal modelsantineoplastic drugscell culturetreatmenttumorurothelialUrinary bladder cancer (UBC) is the second most frequent malignancy of the urinary system and the ninth most common cancer worldwide, affecting individuals over the age of 65. Several investigations have embarked on advancing knowledge of the mechanisms underlying urothelial carcinogenesis, understanding the mechanisms of antineoplastic drugs resistance and discovering new antineoplastic drugs. In vitro and in vivo models are crucial for providing additional insights into the mechanisms of urothelial carcinogenesis. With these models, various molecular pathways involved in urothelial carcinogenesis have been discovered, allowing therapeutic manipulation.Taylor & FrancisRepositório Científico do Instituto Politécnico de ViseuOliveira, Paula AlexandraCosta, Rui Gil daNóbrega, CarmenRodrigues, Regina ArantesLeite, Rosário Pinto2017-01-03T13:29:18Z2016-04-282016-04-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.19/3587engOliveira, P.A., Costa, R. M.G., Nóbrega, C.V., Rodrigues, R.A. & Leite, R. P. (2016). Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery. "Expert opinion on drug discovery", 11(6),599-607. Retrieved fromhttp://www.tandfonline.com/doi/abs/10.1080/17460441.2016.1174690?journalCode=iedc20.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-01-16T15:26:54Zoai:repositorio.ipv.pt:10400.19/3587Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:42:36.891941Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery
title Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery
spellingShingle Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery
Oliveira, Paula Alexandra
Animal models
antineoplastic drugs
cell culture
treatment
tumor
urothelial
title_short Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery
title_full Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery
title_fullStr Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery
title_full_unstemmed Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery
title_sort Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery
author Oliveira, Paula Alexandra
author_facet Oliveira, Paula Alexandra
Costa, Rui Gil da
Nóbrega, Carmen
Rodrigues, Regina Arantes
Leite, Rosário Pinto
author_role author
author2 Costa, Rui Gil da
Nóbrega, Carmen
Rodrigues, Regina Arantes
Leite, Rosário Pinto
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico de Viseu
dc.contributor.author.fl_str_mv Oliveira, Paula Alexandra
Costa, Rui Gil da
Nóbrega, Carmen
Rodrigues, Regina Arantes
Leite, Rosário Pinto
dc.subject.por.fl_str_mv Animal models
antineoplastic drugs
cell culture
treatment
tumor
urothelial
topic Animal models
antineoplastic drugs
cell culture
treatment
tumor
urothelial
description Urinary bladder cancer (UBC) is the second most frequent malignancy of the urinary system and the ninth most common cancer worldwide, affecting individuals over the age of 65. Several investigations have embarked on advancing knowledge of the mechanisms underlying urothelial carcinogenesis, understanding the mechanisms of antineoplastic drugs resistance and discovering new antineoplastic drugs. In vitro and in vivo models are crucial for providing additional insights into the mechanisms of urothelial carcinogenesis. With these models, various molecular pathways involved in urothelial carcinogenesis have been discovered, allowing therapeutic manipulation.
publishDate 2016
dc.date.none.fl_str_mv 2016-04-28
2016-04-28T00:00:00Z
2017-01-03T13:29:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.19/3587
url http://hdl.handle.net/10400.19/3587
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oliveira, P.A., Costa, R. M.G., Nóbrega, C.V., Rodrigues, R.A. & Leite, R. P. (2016). Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery. "Expert opinion on drug discovery", 11(6),599-607. Retrieved fromhttp://www.tandfonline.com/doi/abs/10.1080/17460441.2016.1174690?journalCode=iedc20.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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