Functional brain perfusion evaluation with Arterial Spin Labeling at 3 Tesla

Detalhes bibliográficos
Autor(a) principal: Pimentel, Marco André Figueiredo
Data de Publicação: 2009
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/10570
Resumo: Dissertation submitted in Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa for the degree of Master of Biomedical Engineering
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spelling Functional brain perfusion evaluation with Arterial Spin Labeling at 3 TeslafMRI (functional magnetic resonance imaging)ASL (arterial spin labeling)BOLD (blood oxygen level dependent)CBF (cerebral blood perfusion)Dissertation submitted in Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa for the degree of Master of Biomedical EngineeringBackground: The new clinically available arterial spin labelling (ASL) sequences present some advantages relatively to the commonly used blood oxygenation level dependent (BOLD) method for functional brain studies using magnetic resonance imaging (MRI), namely the fact of being potentially quantitative and more reproducible. Purpose: The main aim of this work was to evaluate the functional use of a commercial ASL sequence implemented on a 3 Tesla MRI system (Siemens, Verio) in the Imaging Department of Hospital da Luz. The first aim was to obtain a functional validation of this technique by comparison with the BOLD contrast, using a number of different approaches. The second aim was to accomplish perfusion quantification, by resolving some important quantification issues. Materials and Methods: Fifteen adult volunteers participated in a single functional imaging session using three different protocols: one using BOLD and two using ASL. The subjects performed a motor finger tapping task and the data analysis was performed using Siemens Neuro3D and FSL (FMRIB’s Software Library). The location and variability of the activated areas were analysed in MNI (Montereal Neurological Institute) standard space. Results: Topographic agreement between the activated regions obtained by BOLD and ASL was found. However, the results show that inter-subject variability and distance to the hand motor cortex were smaller when measured with ASL as compared with BOLD fMRI. Quantitative studies revealed that ASL allows the calculation of cerebral blood flow (CBF), both at baseline and upon functional activation. Conclusion: The results suggest that the functional imaging protocols using ASL produce comparable results to a conventional BOLD protocol, with the additional advantages of reduced inter-subject variability, better spatial specificity and quantification possibilities.Faculdade de Ciências e TecnologiaVilela, PedroFigueiredo, PatríciaRUNPimentel, Marco André Figueiredo2013-10-15T14:16:14Z20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/10570enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T03:44:24Zoai:run.unl.pt:10362/10570Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:19:33.039113Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Functional brain perfusion evaluation with Arterial Spin Labeling at 3 Tesla
title Functional brain perfusion evaluation with Arterial Spin Labeling at 3 Tesla
spellingShingle Functional brain perfusion evaluation with Arterial Spin Labeling at 3 Tesla
Pimentel, Marco André Figueiredo
fMRI (functional magnetic resonance imaging)
ASL (arterial spin labeling)
BOLD (blood oxygen level dependent)
CBF (cerebral blood perfusion)
title_short Functional brain perfusion evaluation with Arterial Spin Labeling at 3 Tesla
title_full Functional brain perfusion evaluation with Arterial Spin Labeling at 3 Tesla
title_fullStr Functional brain perfusion evaluation with Arterial Spin Labeling at 3 Tesla
title_full_unstemmed Functional brain perfusion evaluation with Arterial Spin Labeling at 3 Tesla
title_sort Functional brain perfusion evaluation with Arterial Spin Labeling at 3 Tesla
author Pimentel, Marco André Figueiredo
author_facet Pimentel, Marco André Figueiredo
author_role author
dc.contributor.none.fl_str_mv Vilela, Pedro
Figueiredo, Patrícia
RUN
dc.contributor.author.fl_str_mv Pimentel, Marco André Figueiredo
dc.subject.por.fl_str_mv fMRI (functional magnetic resonance imaging)
ASL (arterial spin labeling)
BOLD (blood oxygen level dependent)
CBF (cerebral blood perfusion)
topic fMRI (functional magnetic resonance imaging)
ASL (arterial spin labeling)
BOLD (blood oxygen level dependent)
CBF (cerebral blood perfusion)
description Dissertation submitted in Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa for the degree of Master of Biomedical Engineering
publishDate 2009
dc.date.none.fl_str_mv 2009
2009-01-01T00:00:00Z
2013-10-15T14:16:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/10570
url http://hdl.handle.net/10362/10570
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137838604746752

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