Neuropsychological contribution to predict conversion to dementia in patients with mild cognitive impairment due to Alzheimer's disease
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/16636 |
Resumo: | Background: Diagnosis of Alzheimer's disease (AD) confirmed by biomarkers allows the patient to make important life decisions. However, doubt about the fleetness of symptoms progression and future cognitive decline remains. Neuropsychological measures were extensively studied in prediction of time to conversion to dementia for mild cognitive impairment (MCI) patients in the absence of biomarker information. Similar neuropsychological measures might also be useful to predict the progression to dementia in patients with MCI due to AD. Objective: To study the contribution of neuropsychological measures to predict time to conversion to dementia in patients with MCI due to AD. Methods: Patients with MCI due toADwere enrolled from a clinical cohort and the effect of neuropsychological performance on time to conversion to dementia was analyzed. Results: At baseline, converters scored lower than non-converters at measures of verbal initiative, non-verbal reasoning, and episodic memory. The test of non-verbal reasoning was the only statistically significant predictor in a multivariate Cox regression model. A decrease of one standard deviation was associated with 29% of increase in the risk of conversion to dementia. Approximately 50% of patients with more than one standard deviation below the mean in the z score of that test had converted to dementia after 3 years of follow-up. Conclusion: In MCI due to AD, lower performance in a test of non-verbal reasoning was associated with time to conversion to dementia. This test, that reveals little decline in the earlier phases of AD, appears to convey important information concerning conversion to dementia. |
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Neuropsychological contribution to predict conversion to dementia in patients with mild cognitive impairment due to Alzheimer's diseaseAlzheimer's disease (AD)Amyloid-betaCognitive impairmentDementiaMild cognitive impairment due to ADEuropsychological assessmentProdromal ADRaven coloured progressive matricesBackground: Diagnosis of Alzheimer's disease (AD) confirmed by biomarkers allows the patient to make important life decisions. However, doubt about the fleetness of symptoms progression and future cognitive decline remains. Neuropsychological measures were extensively studied in prediction of time to conversion to dementia for mild cognitive impairment (MCI) patients in the absence of biomarker information. Similar neuropsychological measures might also be useful to predict the progression to dementia in patients with MCI due to AD. Objective: To study the contribution of neuropsychological measures to predict time to conversion to dementia in patients with MCI due to AD. Methods: Patients with MCI due toADwere enrolled from a clinical cohort and the effect of neuropsychological performance on time to conversion to dementia was analyzed. Results: At baseline, converters scored lower than non-converters at measures of verbal initiative, non-verbal reasoning, and episodic memory. The test of non-verbal reasoning was the only statistically significant predictor in a multivariate Cox regression model. A decrease of one standard deviation was associated with 29% of increase in the risk of conversion to dementia. Approximately 50% of patients with more than one standard deviation below the mean in the z score of that test had converted to dementia after 3 years of follow-up. Conclusion: In MCI due to AD, lower performance in a test of non-verbal reasoning was associated with time to conversion to dementia. This test, that reveals little decline in the earlier phases of AD, appears to convey important information concerning conversion to dementia.Fundacao para a Ciencia e Tecnologia (FCT)Portuguese Foundation for Science and TechnologyEuropean Commission [PTDC/MED-NEU/27946/2017]IOS PressSapientiaSilva, DinaCardoso, SandraGuerreiro, ManuelaMaroco, JoaoMendes, TiagoAlves, LuisaNogueira, JoanaBaldeiras, InesSantana, Isabelde Mendonca, Alexandre2021-06-24T11:36:07Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/16636eng1387-287710.3233/JAD-191133info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:28:36Zoai:sapientia.ualg.pt:10400.1/16636Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:06:44.448045Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Neuropsychological contribution to predict conversion to dementia in patients with mild cognitive impairment due to Alzheimer's disease |
title |
Neuropsychological contribution to predict conversion to dementia in patients with mild cognitive impairment due to Alzheimer's disease |
spellingShingle |
Neuropsychological contribution to predict conversion to dementia in patients with mild cognitive impairment due to Alzheimer's disease Silva, Dina Alzheimer's disease (AD) Amyloid-beta Cognitive impairment Dementia Mild cognitive impairment due to AD Europsychological assessment Prodromal AD Raven coloured progressive matrices |
title_short |
Neuropsychological contribution to predict conversion to dementia in patients with mild cognitive impairment due to Alzheimer's disease |
title_full |
Neuropsychological contribution to predict conversion to dementia in patients with mild cognitive impairment due to Alzheimer's disease |
title_fullStr |
Neuropsychological contribution to predict conversion to dementia in patients with mild cognitive impairment due to Alzheimer's disease |
title_full_unstemmed |
Neuropsychological contribution to predict conversion to dementia in patients with mild cognitive impairment due to Alzheimer's disease |
title_sort |
Neuropsychological contribution to predict conversion to dementia in patients with mild cognitive impairment due to Alzheimer's disease |
author |
Silva, Dina |
author_facet |
Silva, Dina Cardoso, Sandra Guerreiro, Manuela Maroco, Joao Mendes, Tiago Alves, Luisa Nogueira, Joana Baldeiras, Ines Santana, Isabel de Mendonca, Alexandre |
author_role |
author |
author2 |
Cardoso, Sandra Guerreiro, Manuela Maroco, Joao Mendes, Tiago Alves, Luisa Nogueira, Joana Baldeiras, Ines Santana, Isabel de Mendonca, Alexandre |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Silva, Dina Cardoso, Sandra Guerreiro, Manuela Maroco, Joao Mendes, Tiago Alves, Luisa Nogueira, Joana Baldeiras, Ines Santana, Isabel de Mendonca, Alexandre |
dc.subject.por.fl_str_mv |
Alzheimer's disease (AD) Amyloid-beta Cognitive impairment Dementia Mild cognitive impairment due to AD Europsychological assessment Prodromal AD Raven coloured progressive matrices |
topic |
Alzheimer's disease (AD) Amyloid-beta Cognitive impairment Dementia Mild cognitive impairment due to AD Europsychological assessment Prodromal AD Raven coloured progressive matrices |
description |
Background: Diagnosis of Alzheimer's disease (AD) confirmed by biomarkers allows the patient to make important life decisions. However, doubt about the fleetness of symptoms progression and future cognitive decline remains. Neuropsychological measures were extensively studied in prediction of time to conversion to dementia for mild cognitive impairment (MCI) patients in the absence of biomarker information. Similar neuropsychological measures might also be useful to predict the progression to dementia in patients with MCI due to AD. Objective: To study the contribution of neuropsychological measures to predict time to conversion to dementia in patients with MCI due to AD. Methods: Patients with MCI due toADwere enrolled from a clinical cohort and the effect of neuropsychological performance on time to conversion to dementia was analyzed. Results: At baseline, converters scored lower than non-converters at measures of verbal initiative, non-verbal reasoning, and episodic memory. The test of non-verbal reasoning was the only statistically significant predictor in a multivariate Cox regression model. A decrease of one standard deviation was associated with 29% of increase in the risk of conversion to dementia. Approximately 50% of patients with more than one standard deviation below the mean in the z score of that test had converted to dementia after 3 years of follow-up. Conclusion: In MCI due to AD, lower performance in a test of non-verbal reasoning was associated with time to conversion to dementia. This test, that reveals little decline in the earlier phases of AD, appears to convey important information concerning conversion to dementia. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2021-06-24T11:36:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/16636 |
url |
http://hdl.handle.net/10400.1/16636 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1387-2877 10.3233/JAD-191133 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
IOS Press |
publisher.none.fl_str_mv |
IOS Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133310151032832 |