Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection

Detalhes bibliográficos
Autor(a) principal: Skarlatou, Sophie
Data de Publicação: 2020
Outros Autores: Hérent, Coralie, Toscano, Elisa, Mendes, César S., Bouvier, Julien, Zampieri, Niccolò
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/100939
Resumo: Skarlatou et al. report that afadin function in the developing spinal neuroepithelium controls organization of the midline. Afadin elimination from the motor neuron progenitor zone results in duplication of the central canal, aberrant wiring of dI4-5, V0, and V2a premotor neurons, and loss of left-right limb alternation.
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spelling Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait SelectionAfadincentral canal developmentgaitlocomotor circuitspremotor connectivityspinal cordspinal interneuronsBiochemistry, Genetics and Molecular Biology(all)Skarlatou et al. report that afadin function in the developing spinal neuroepithelium controls organization of the midline. Afadin elimination from the motor neuron progenitor zone results in duplication of the central canal, aberrant wiring of dI4-5, V0, and V2a premotor neurons, and loss of left-right limb alternation.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSkarlatou, SophieHérent, CoralieToscano, ElisaMendes, César S.Bouvier, JulienZampieri, Niccolò2020-07-15T23:10:45Z2020-06-092020-06-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/100939eng2211-1247PURE: 19061627https://doi.org/10.1016/j.celrep.2020.107741info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:47:16Zoai:run.unl.pt:10362/100939Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:39:27.712555Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection
title Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection
spellingShingle Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection
Skarlatou, Sophie
Afadin
central canal development
gait
locomotor circuits
premotor connectivity
spinal cord
spinal interneurons
Biochemistry, Genetics and Molecular Biology(all)
title_short Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection
title_full Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection
title_fullStr Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection
title_full_unstemmed Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection
title_sort Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection
author Skarlatou, Sophie
author_facet Skarlatou, Sophie
Hérent, Coralie
Toscano, Elisa
Mendes, César S.
Bouvier, Julien
Zampieri, Niccolò
author_role author
author2 Hérent, Coralie
Toscano, Elisa
Mendes, César S.
Bouvier, Julien
Zampieri, Niccolò
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Skarlatou, Sophie
Hérent, Coralie
Toscano, Elisa
Mendes, César S.
Bouvier, Julien
Zampieri, Niccolò
dc.subject.por.fl_str_mv Afadin
central canal development
gait
locomotor circuits
premotor connectivity
spinal cord
spinal interneurons
Biochemistry, Genetics and Molecular Biology(all)
topic Afadin
central canal development
gait
locomotor circuits
premotor connectivity
spinal cord
spinal interneurons
Biochemistry, Genetics and Molecular Biology(all)
description Skarlatou et al. report that afadin function in the developing spinal neuroepithelium controls organization of the midline. Afadin elimination from the motor neuron progenitor zone results in duplication of the central canal, aberrant wiring of dI4-5, V0, and V2a premotor neurons, and loss of left-right limb alternation.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-15T23:10:45Z
2020-06-09
2020-06-09T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/100939
url http://hdl.handle.net/10362/100939
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2211-1247
PURE: 19061627
https://doi.org/10.1016/j.celrep.2020.107741
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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