ALTernative functions for human FANCM at telomeres

Detalhes bibliográficos
Autor(a) principal: Domingues Silva, Ana Beatriz
Data de Publicação: 2019
Outros Autores: Silva, Bruno, Azzalin, Claus Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/47079
Resumo: Copyright © 2019 Domingues-Silva, Silva and Azzalin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling ALTernative functions for human FANCM at telomeresFANCMTelomeresALTR-loopsTERRABLM helicaseCopyright © 2019 Domingues-Silva, Silva and Azzalin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.The human FANCM ATPase/translocase is involved in various cellular pathways including DNA damage repair, replication fork remodeling and R-loop resolution. Recently, reports from three independent laboratories have disclosed a previously unappreciated role for FANCM in telomerase-negative human cancer cells that maintain their telomeres through the Alternative Lengthening of Telomeres (ALT) pathway. In ALT cells, FANCM limits telomeric replication stress and damage, and, in turn, ALT activity by suppressing accumulation of telomeric R-loops and by regulating the action of the BLM helicase. As a consequence, FANCM inactivation leads to exaggerated ALT activity and ultimately cell death. The studies reviewed here not only unveil a novel function for human FANCM, but also point to this enzyme as a promising target for anti-ALT cancer therapy.Research in the Azzalin laboratory is supported by the European Molecular Biology Organization (IG3576) and the Fundação para a Ciência e a Tecnologia (IF/01269/2015; PTDC/BIA-MOL/29352/2017; PTDC/MED-ONC/28282/2017). Publication costs were supported by UID/BIM/50005/2019, project funded by the Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through Fundos do Orçamento de Estado.FrontiersRepositório da Universidade de LisboaDomingues Silva, Ana BeatrizSilva, BrunoAzzalin, Claus Maria2021-03-25T16:43:24Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47079engFront Mol Biosci. 2019 Sep 6;6:84.10.3389/fmolb.2019.000842296-889Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:43Zoai:repositorio.ul.pt:10451/47079Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:09.588647Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv ALTernative functions for human FANCM at telomeres
title ALTernative functions for human FANCM at telomeres
spellingShingle ALTernative functions for human FANCM at telomeres
Domingues Silva, Ana Beatriz
FANCM
Telomeres
ALT
R-loops
TERRA
BLM helicase
title_short ALTernative functions for human FANCM at telomeres
title_full ALTernative functions for human FANCM at telomeres
title_fullStr ALTernative functions for human FANCM at telomeres
title_full_unstemmed ALTernative functions for human FANCM at telomeres
title_sort ALTernative functions for human FANCM at telomeres
author Domingues Silva, Ana Beatriz
author_facet Domingues Silva, Ana Beatriz
Silva, Bruno
Azzalin, Claus Maria
author_role author
author2 Silva, Bruno
Azzalin, Claus Maria
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Domingues Silva, Ana Beatriz
Silva, Bruno
Azzalin, Claus Maria
dc.subject.por.fl_str_mv FANCM
Telomeres
ALT
R-loops
TERRA
BLM helicase
topic FANCM
Telomeres
ALT
R-loops
TERRA
BLM helicase
description Copyright © 2019 Domingues-Silva, Silva and Azzalin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2021-03-25T16:43:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47079
url http://hdl.handle.net/10451/47079
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Mol Biosci. 2019 Sep 6;6:84.
10.3389/fmolb.2019.00084
2296-889X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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