Stalling the course of neurodegenerative diseases: could cyanobacteria constitute a new approach toward therapy?

Detalhes bibliográficos
Autor(a) principal: Ramos, Vitória
Data de Publicação: 2023
Outros Autores: Reis, Mariana, Ferreira, Leonor, Silva, Ana Margarida, Ferraz, Ricardo, Vieira, Mónica, Vasconcelos, Vitor, Martins, Rosario
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/23631
Resumo: Neurodegenerative diseases (NDs) are characterized by progressive and irreversible neuronal loss, accompanied by a range of pathological pathways, including aberrant protein aggregation, altered energy metabolism, excitotoxicity, inflammation, and oxidative stress. Some of the most common NDs include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), and Huntington’s Disease (HD). There are currently no available cures; there are only therapeutic approaches that ameliorate the progression of symptoms, which makes the search for new drugs and therapeutic targets a constant battle. Cyanobacteria are ancient prokaryotic oxygenic phototrophs whose long evolutionary history has resulted in the production of a plethora of biomedically relevant compounds with anti-inflammatory, antioxidant, immunomodulatory, and neuroprotective properties, that can be valuable in this field. This review summarizes the major NDs and their pathophysiology, with a focus on the anti-neurodegenerative properties of cyanobacterial compounds and their main effects.
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spelling Stalling the course of neurodegenerative diseases: could cyanobacteria constitute a new approach toward therapy?CyanobacteriaSpirulinaNeurodegenerative diseasesNatural productsNeurodegenerative diseases (NDs) are characterized by progressive and irreversible neuronal loss, accompanied by a range of pathological pathways, including aberrant protein aggregation, altered energy metabolism, excitotoxicity, inflammation, and oxidative stress. Some of the most common NDs include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), and Huntington’s Disease (HD). There are currently no available cures; there are only therapeutic approaches that ameliorate the progression of symptoms, which makes the search for new drugs and therapeutic targets a constant battle. Cyanobacteria are ancient prokaryotic oxygenic phototrophs whose long evolutionary history has resulted in the production of a plethora of biomedically relevant compounds with anti-inflammatory, antioxidant, immunomodulatory, and neuroprotective properties, that can be valuable in this field. This review summarizes the major NDs and their pathophysiology, with a focus on the anti-neurodegenerative properties of cyanobacterial compounds and their main effects.MDPIRepositório Científico do Instituto Politécnico do PortoRamos, VitóriaReis, MarianaFerreira, LeonorSilva, Ana MargaridaFerraz, RicardoVieira, MónicaVasconcelos, VitorMartins, Rosario2023-10-02T13:52:50Z2023-092023-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/23631engRamos, V., Reis, M., Ferreira, L., Silva, A. M., Ferraz, R., Vieira, M., Vasconcelos, V., & Martins, R. (2023). Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy? Biomolecules, 13(10), Artigo 10. https://doi.org/10.3390/biom1310144410.3390/biom131014442218-273Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-04T01:45:41Zoai:recipp.ipp.pt:10400.22/23631Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:33:15.171075Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Stalling the course of neurodegenerative diseases: could cyanobacteria constitute a new approach toward therapy?
title Stalling the course of neurodegenerative diseases: could cyanobacteria constitute a new approach toward therapy?
spellingShingle Stalling the course of neurodegenerative diseases: could cyanobacteria constitute a new approach toward therapy?
Ramos, Vitória
Cyanobacteria
Spirulina
Neurodegenerative diseases
Natural products
title_short Stalling the course of neurodegenerative diseases: could cyanobacteria constitute a new approach toward therapy?
title_full Stalling the course of neurodegenerative diseases: could cyanobacteria constitute a new approach toward therapy?
title_fullStr Stalling the course of neurodegenerative diseases: could cyanobacteria constitute a new approach toward therapy?
title_full_unstemmed Stalling the course of neurodegenerative diseases: could cyanobacteria constitute a new approach toward therapy?
title_sort Stalling the course of neurodegenerative diseases: could cyanobacteria constitute a new approach toward therapy?
author Ramos, Vitória
author_facet Ramos, Vitória
Reis, Mariana
Ferreira, Leonor
Silva, Ana Margarida
Ferraz, Ricardo
Vieira, Mónica
Vasconcelos, Vitor
Martins, Rosario
author_role author
author2 Reis, Mariana
Ferreira, Leonor
Silva, Ana Margarida
Ferraz, Ricardo
Vieira, Mónica
Vasconcelos, Vitor
Martins, Rosario
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Ramos, Vitória
Reis, Mariana
Ferreira, Leonor
Silva, Ana Margarida
Ferraz, Ricardo
Vieira, Mónica
Vasconcelos, Vitor
Martins, Rosario
dc.subject.por.fl_str_mv Cyanobacteria
Spirulina
Neurodegenerative diseases
Natural products
topic Cyanobacteria
Spirulina
Neurodegenerative diseases
Natural products
description Neurodegenerative diseases (NDs) are characterized by progressive and irreversible neuronal loss, accompanied by a range of pathological pathways, including aberrant protein aggregation, altered energy metabolism, excitotoxicity, inflammation, and oxidative stress. Some of the most common NDs include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), and Huntington’s Disease (HD). There are currently no available cures; there are only therapeutic approaches that ameliorate the progression of symptoms, which makes the search for new drugs and therapeutic targets a constant battle. Cyanobacteria are ancient prokaryotic oxygenic phototrophs whose long evolutionary history has resulted in the production of a plethora of biomedically relevant compounds with anti-inflammatory, antioxidant, immunomodulatory, and neuroprotective properties, that can be valuable in this field. This review summarizes the major NDs and their pathophysiology, with a focus on the anti-neurodegenerative properties of cyanobacterial compounds and their main effects.
publishDate 2023
dc.date.none.fl_str_mv 2023-10-02T13:52:50Z
2023-09
2023-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/23631
url http://hdl.handle.net/10400.22/23631
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ramos, V., Reis, M., Ferreira, L., Silva, A. M., Ferraz, R., Vieira, M., Vasconcelos, V., & Martins, R. (2023). Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy? Biomolecules, 13(10), Artigo 10. https://doi.org/10.3390/biom13101444
10.3390/biom13101444
2218-273X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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