Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugal

Detalhes bibliográficos
Autor(a) principal: Bigotte Vieira, Miguel
Data de Publicação: 2019
Outros Autores: Sérgio Neves, João, Baeta Baptista, Rute, Leitão, Lia, Viegas Dias, Catarina, Vicente, Ricardo, Nascimento, Nilton, Costa Leite, Celina, Rocha, Isabel, Magriço, Rita
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10815
Resumo: Introduction: Portugal presents the highest incidence of stage 5 chronic kidney disease in Europe. It is speculated that a high consumption of non-steroidal anti-inflammatory drugs (NSAIDS) may contribute to this high incidence. Our aim was to characterize the prescription of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus in Portugal.Material and Methods: We analyzed the national prescription database in triennium 2015 - 2017. In patients with diabetes mellitus, we evaluated the prescription of non-steroidal anti-inflammatory drugs according to age, gender and region of the patient and specialty of the prescribing physician. We evaluated the prescription of non-steroidal anti-inflammatory drugs in all patients with diabetes mellitus, in patients with presumed renal impairment, and in those with concomitant prescription of angiotensin converting enzyme inhibitors or angiotensin receptor antagonists.Results: We analyzed 23 320 620 prescriptions, corresponding to 610 157 adults, including 104 306 patients with diabetes mellitus. The most prescribed non-steroidal anti-inflammatory drugs were ibuprofen (20.1%), metamizole (14.7%), and diclofenac (11.4%). The prescription of non-steroidal anti-inflammatory drugs was higher in females, in patients aged 51 - 70 years and in the Alentejo region. Non-steroidal anti-inflammatory drugs were prescribed to 70.6% of patients with diabetes mellitus, from which 10.6% were prescribed ≥ 10 packages during the three years. Among patients with diabetes mellitus on angiotensin converting enzyme inhibitors/angiotensin receptor antagonists and with presumed reduction in kidney function, 69.3% were prescribed non-steroidal anti-inflammatory drugs and 11.5% were prescribed ≥ 10 packages during the three years.Discussion: The level of prescribing of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus is high. The concern of reducing non-steroidal anti-inflammatory drugs prescription to patients already on angiotensin converting enzyme inhibitors/angiotensin receptor antagonists and/or decreased renal function does not seem to exist.Conclusion: In Portugal, the level of prescribing of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus should be reduced, particularly in the subgroups identified with higher prescription and with higher risk of progression to stage 5 chronic kidney disease.
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spelling Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in PortugalPrescrição de Anti-Inflamatórios Não Esteroides a Doentes com Diabetes Mellitus em PortugalAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsAnti-Inflammatory AgentsNon-SteroidalDiabetes MellitusRenal InsufficiencyChronicAntagonistas de Receptores de AngiotensinaAnti-Inflamatórios não EsteroidesDiabetes MellitusInibidores da Enzima Conversora de AngiotensinaInsuficiência Renal CrónicaIntroduction: Portugal presents the highest incidence of stage 5 chronic kidney disease in Europe. It is speculated that a high consumption of non-steroidal anti-inflammatory drugs (NSAIDS) may contribute to this high incidence. Our aim was to characterize the prescription of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus in Portugal.Material and Methods: We analyzed the national prescription database in triennium 2015 - 2017. In patients with diabetes mellitus, we evaluated the prescription of non-steroidal anti-inflammatory drugs according to age, gender and region of the patient and specialty of the prescribing physician. We evaluated the prescription of non-steroidal anti-inflammatory drugs in all patients with diabetes mellitus, in patients with presumed renal impairment, and in those with concomitant prescription of angiotensin converting enzyme inhibitors or angiotensin receptor antagonists.Results: We analyzed 23 320 620 prescriptions, corresponding to 610 157 adults, including 104 306 patients with diabetes mellitus. The most prescribed non-steroidal anti-inflammatory drugs were ibuprofen (20.1%), metamizole (14.7%), and diclofenac (11.4%). The prescription of non-steroidal anti-inflammatory drugs was higher in females, in patients aged 51 - 70 years and in the Alentejo region. Non-steroidal anti-inflammatory drugs were prescribed to 70.6% of patients with diabetes mellitus, from which 10.6% were prescribed ≥ 10 packages during the three years. Among patients with diabetes mellitus on angiotensin converting enzyme inhibitors/angiotensin receptor antagonists and with presumed reduction in kidney function, 69.3% were prescribed non-steroidal anti-inflammatory drugs and 11.5% were prescribed ≥ 10 packages during the three years.Discussion: The level of prescribing of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus is high. The concern of reducing non-steroidal anti-inflammatory drugs prescription to patients already on angiotensin converting enzyme inhibitors/angiotensin receptor antagonists and/or decreased renal function does not seem to exist.Conclusion: In Portugal, the level of prescribing of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus should be reduced, particularly in the subgroups identified with higher prescription and with higher risk of progression to stage 5 chronic kidney disease.Introdução: Portugal apresenta a incidência mais elevada de doença renal crónica estádio 5 na Europa. Especula-se que o elevado consumo de anti-inflamatórios não esteroides possa contribuir para esta incidência. O objetivo do presente estudo foi caracterizar a prescrição de anti-inflamatórios não esteroides a doentes com diabetes mellitus em Portugal.Material e Métodos: Na Base de Dados Nacional de Prescrições do Ministério da Saúde, triénio 2015 - 2017, analisámos a prescrição de anti-inflamatórios não esteroides em doentes com diabetes mellitus, de acordo com a idade, género e região do doente e a especialidade do médico prescritor. Avaliámos a prescrição de anti-inflamatórios não esteroides no total de doentes com diabetes mellitus, em doentes com diminuição presumida da função renal e naqueles com prescrição concomitante de inibidores da enzima de conversão da angiotensina ou antagonistas dos recetores da angiotensina.Resultados: Analisámos 23 320 620 prescrições, correspondendo a 610 157 adultos, dos quais 104 306 doentes com diabetes mellitus. Os anti-inflamatórios não esteroides mais prescritos foram ibuprofeno (20,1%), metamizol (14,7%) e diclofenac (11,4%). A prescrição foi mais frequente nas mulheres, nos doentes com 51 - 70 anos e no Alentejo. Foram prescritos anti-inflamatórios não esteroides a 70,6% dos doentes com diabetes mellitus, dos quais 10,6% receberam prescrições de ≥ 10 embalagens durante os três anos. Dos doentes com diabetes mellitus medicados com inibidores da enzima de conversão da angiotensina ou antagonistas dos receptores da angiotensina e com diminuição presumida da taxa de filtração glomerular, 69,3% receberam prescrição de anti-inflamatórios não esteroides e 11,5% receberam ≥ 10 embalagens durante os três anos. Discussão: A prescrição de anti-inflamatórios não esteroides na diabetes mellitus é elevada. Não parece existir uma preocupação na menor utilização de anti-inflamatórios não esteroides em doentes simultaneamente medicados com inibidores da enzima de conversão da angiotensina ou antagonistas dos recetores da angiotensina e/ou com diminuição da função renal.Conclusão: A prescrição de anti-inflamatórios não esteroides em Portugal a doentes com diabetes mellitus deverá ser reduzida, particularmente nos subgrupos identificados com prescrição mais elevada e com maior risco de progressão para doença renal crónica estádio 5.Ordem dos Médicos2019-02-28info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10815oai:ojs.www.actamedicaportuguesa.com:article/10815Acta Médica Portuguesa; Vol. 32 No. 2 (2019): February; 119-125Acta Médica Portuguesa; Vol. 32 N.º 2 (2019): Fevereiro; 119-1251646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10815https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10815/5618https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10815/6090https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10815/10423https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10815/10424https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10815/10547https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10815/10548https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10815/10653Direitos de Autor (c) 2019 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessBigotte Vieira, MiguelSérgio Neves, JoãoBaeta Baptista, RuteLeitão, LiaViegas Dias, CatarinaVicente, RicardoNascimento, NiltonCosta Leite, CelinaRocha, IsabelMagriço, Rita2022-12-20T11:06:05Zoai:ojs.www.actamedicaportuguesa.com:article/10815Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:56.874402Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugal
Prescrição de Anti-Inflamatórios Não Esteroides a Doentes com Diabetes Mellitus em Portugal
title Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugal
spellingShingle Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugal
Bigotte Vieira, Miguel
Angiotensin-Converting Enzyme Inhibitors
Angiotensin Receptor Antagonists
Anti-Inflammatory Agents
Non-Steroidal
Diabetes Mellitus
Renal Insufficiency
Chronic
Antagonistas de Receptores de Angiotensina
Anti-Inflamatórios não Esteroides
Diabetes Mellitus
Inibidores da Enzima Conversora de Angiotensina
Insuficiência Renal Crónica
title_short Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugal
title_full Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugal
title_fullStr Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugal
title_full_unstemmed Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugal
title_sort Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugal
author Bigotte Vieira, Miguel
author_facet Bigotte Vieira, Miguel
Sérgio Neves, João
Baeta Baptista, Rute
Leitão, Lia
Viegas Dias, Catarina
Vicente, Ricardo
Nascimento, Nilton
Costa Leite, Celina
Rocha, Isabel
Magriço, Rita
author_role author
author2 Sérgio Neves, João
Baeta Baptista, Rute
Leitão, Lia
Viegas Dias, Catarina
Vicente, Ricardo
Nascimento, Nilton
Costa Leite, Celina
Rocha, Isabel
Magriço, Rita
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bigotte Vieira, Miguel
Sérgio Neves, João
Baeta Baptista, Rute
Leitão, Lia
Viegas Dias, Catarina
Vicente, Ricardo
Nascimento, Nilton
Costa Leite, Celina
Rocha, Isabel
Magriço, Rita
dc.subject.por.fl_str_mv Angiotensin-Converting Enzyme Inhibitors
Angiotensin Receptor Antagonists
Anti-Inflammatory Agents
Non-Steroidal
Diabetes Mellitus
Renal Insufficiency
Chronic
Antagonistas de Receptores de Angiotensina
Anti-Inflamatórios não Esteroides
Diabetes Mellitus
Inibidores da Enzima Conversora de Angiotensina
Insuficiência Renal Crónica
topic Angiotensin-Converting Enzyme Inhibitors
Angiotensin Receptor Antagonists
Anti-Inflammatory Agents
Non-Steroidal
Diabetes Mellitus
Renal Insufficiency
Chronic
Antagonistas de Receptores de Angiotensina
Anti-Inflamatórios não Esteroides
Diabetes Mellitus
Inibidores da Enzima Conversora de Angiotensina
Insuficiência Renal Crónica
description Introduction: Portugal presents the highest incidence of stage 5 chronic kidney disease in Europe. It is speculated that a high consumption of non-steroidal anti-inflammatory drugs (NSAIDS) may contribute to this high incidence. Our aim was to characterize the prescription of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus in Portugal.Material and Methods: We analyzed the national prescription database in triennium 2015 - 2017. In patients with diabetes mellitus, we evaluated the prescription of non-steroidal anti-inflammatory drugs according to age, gender and region of the patient and specialty of the prescribing physician. We evaluated the prescription of non-steroidal anti-inflammatory drugs in all patients with diabetes mellitus, in patients with presumed renal impairment, and in those with concomitant prescription of angiotensin converting enzyme inhibitors or angiotensin receptor antagonists.Results: We analyzed 23 320 620 prescriptions, corresponding to 610 157 adults, including 104 306 patients with diabetes mellitus. The most prescribed non-steroidal anti-inflammatory drugs were ibuprofen (20.1%), metamizole (14.7%), and diclofenac (11.4%). The prescription of non-steroidal anti-inflammatory drugs was higher in females, in patients aged 51 - 70 years and in the Alentejo region. Non-steroidal anti-inflammatory drugs were prescribed to 70.6% of patients with diabetes mellitus, from which 10.6% were prescribed ≥ 10 packages during the three years. Among patients with diabetes mellitus on angiotensin converting enzyme inhibitors/angiotensin receptor antagonists and with presumed reduction in kidney function, 69.3% were prescribed non-steroidal anti-inflammatory drugs and 11.5% were prescribed ≥ 10 packages during the three years.Discussion: The level of prescribing of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus is high. The concern of reducing non-steroidal anti-inflammatory drugs prescription to patients already on angiotensin converting enzyme inhibitors/angiotensin receptor antagonists and/or decreased renal function does not seem to exist.Conclusion: In Portugal, the level of prescribing of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus should be reduced, particularly in the subgroups identified with higher prescription and with higher risk of progression to stage 5 chronic kidney disease.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-28
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10815/6090
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 32 No. 2 (2019): February; 119-125
Acta Médica Portuguesa; Vol. 32 N.º 2 (2019): Fevereiro; 119-125
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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