Corticospinal Suppression Underlying Intact Movement Preparation Fades in Parkinson's Disease

Detalhes bibliográficos
Autor(a) principal: Wilhelm, Emmanuelle
Data de Publicação: 2022
Outros Autores: Quoilin, Caroline, Derosiere, Gerard, Paço, Susana, Jeanjean, Anne, Duque, Julie
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/144402
Resumo: Wilhelm, E., Quoilin, C., Derosiere, G., Paço, S., Jeanjean, A., & Duque, J. (2022). Corticospinal Suppression Underlying Intact Movement Preparation Fades in Parkinson's Disease. Movement Disorders, 37(12), 2396-2406. https://doi.org/10.1002/mds.29214. ---- Funding agencies: This work was supported by grants fromFondsSpéciaux de Recherche(FSR; IONS-FSR16 DUQUE) andAction deRecherche Concertée-Parkinson(ARC; M1.21303.001) of theUniversité catholique de Louvain, the Belgian National Funds for Scien-tific Research (FRS-FNRS: MIS F.4512.14), andFondation MédicaleReine Elisabeth. During the research project, E.W. was a doctoral stu-dent supported by the L’Oréal-UNESCO“For Women in Science”pro-gram and the FRS–FNRS (1.A938.18). C.Q. and G.D. were postdoctoralfellows supported by the FRS–FNRS (1.B358.18, 1.B134.18).
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spelling Corticospinal Suppression Underlying Intact Movement Preparation Fades in Parkinson's DiseaseParkinson’s diseaseMotor cortexBradykinesiaMotor controlTranscranial magnetic stimulationNeurologyClinical NeurologySDG 3 - Good Health and Well-beingWilhelm, E., Quoilin, C., Derosiere, G., Paço, S., Jeanjean, A., & Duque, J. (2022). Corticospinal Suppression Underlying Intact Movement Preparation Fades in Parkinson's Disease. Movement Disorders, 37(12), 2396-2406. https://doi.org/10.1002/mds.29214. ---- Funding agencies: This work was supported by grants fromFondsSpéciaux de Recherche(FSR; IONS-FSR16 DUQUE) andAction deRecherche Concertée-Parkinson(ARC; M1.21303.001) of theUniversité catholique de Louvain, the Belgian National Funds for Scien-tific Research (FRS-FNRS: MIS F.4512.14), andFondation MédicaleReine Elisabeth. During the research project, E.W. was a doctoral stu-dent supported by the L’Oréal-UNESCO“For Women in Science”pro-gram and the FRS–FNRS (1.A938.18). C.Q. and G.D. were postdoctoralfellows supported by the FRS–FNRS (1.B358.18, 1.B134.18).Abstract Background In Parkinson's disease (PD), neurophysiological abnormalities within the primary motor cortex (M1) have been shown to contribute to bradykinesia, but exact modalities are still uncertain. We propose that such motor slowness could involve alterations in mechanisms underlying movement preparation, especially the suppression of corticospinal excitability—called “preparatory suppression”—which is considered to propel movement execution by increasing motor neural gain in healthy individuals. Methods On two consecutive days, 29 PD patients (on and off medication) and 29 matched healthy controls (HCs) underwent transcranial magnetic stimulation over M1, eliciting motor-evoked potentials (MEPs) in targeted hand muscles, while they were either at rest or preparing a left- or right-hand response in an instructed-delay choice reaction time task. Preparatory suppression was assessed by expressing MEP amplitudes during movement preparation relative to rest. Results Contrary to HCs, PD patients showed a lack of preparatory suppression when the side of the responding hand was analyzed, especially when the latter was the most affected one. This deficit, which did not depend on dopamine medication, increased with disease duration and also tended to correlate with motor impairment, as measured by the Movement Disorder Society Unified Parkinson's Disease Rating Scale, Part III (both total and bradykinesia scores). Conclusions Our novel findings indicate that preparatory suppression fades in PD, in parallel with worsening motor symptoms, including bradykinesia. Such results suggest that an alteration in this marker of intact movement preparation could indeed cause motor slowness and support its use in future studies on the relation between M1 alterations and motor impairment in PD. © 2022 International Parkinson and Movement Disorder Society.NOVA Information Management School (NOVA IMS)RUNWilhelm, EmmanuelleQuoilin, CarolineDerosiere, GerardPaço, SusanaJeanjean, AnneDuque, Julie2023-09-02T00:31:10Z2022-12-012022-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/144402eng0885-3185PURE: 46803897https://doi.org/10.1002/mds.29214info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:24:04Zoai:run.unl.pt:10362/144402Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:51:32.427027Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Corticospinal Suppression Underlying Intact Movement Preparation Fades in Parkinson's Disease
title Corticospinal Suppression Underlying Intact Movement Preparation Fades in Parkinson's Disease
spellingShingle Corticospinal Suppression Underlying Intact Movement Preparation Fades in Parkinson's Disease
Wilhelm, Emmanuelle
Parkinson’s disease
Motor cortex
Bradykinesia
Motor control
Transcranial magnetic stimulation
Neurology
Clinical Neurology
SDG 3 - Good Health and Well-being
title_short Corticospinal Suppression Underlying Intact Movement Preparation Fades in Parkinson's Disease
title_full Corticospinal Suppression Underlying Intact Movement Preparation Fades in Parkinson's Disease
title_fullStr Corticospinal Suppression Underlying Intact Movement Preparation Fades in Parkinson's Disease
title_full_unstemmed Corticospinal Suppression Underlying Intact Movement Preparation Fades in Parkinson's Disease
title_sort Corticospinal Suppression Underlying Intact Movement Preparation Fades in Parkinson's Disease
author Wilhelm, Emmanuelle
author_facet Wilhelm, Emmanuelle
Quoilin, Caroline
Derosiere, Gerard
Paço, Susana
Jeanjean, Anne
Duque, Julie
author_role author
author2 Quoilin, Caroline
Derosiere, Gerard
Paço, Susana
Jeanjean, Anne
Duque, Julie
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Information Management School (NOVA IMS)
RUN
dc.contributor.author.fl_str_mv Wilhelm, Emmanuelle
Quoilin, Caroline
Derosiere, Gerard
Paço, Susana
Jeanjean, Anne
Duque, Julie
dc.subject.por.fl_str_mv Parkinson’s disease
Motor cortex
Bradykinesia
Motor control
Transcranial magnetic stimulation
Neurology
Clinical Neurology
SDG 3 - Good Health and Well-being
topic Parkinson’s disease
Motor cortex
Bradykinesia
Motor control
Transcranial magnetic stimulation
Neurology
Clinical Neurology
SDG 3 - Good Health and Well-being
description Wilhelm, E., Quoilin, C., Derosiere, G., Paço, S., Jeanjean, A., & Duque, J. (2022). Corticospinal Suppression Underlying Intact Movement Preparation Fades in Parkinson's Disease. Movement Disorders, 37(12), 2396-2406. https://doi.org/10.1002/mds.29214. ---- Funding agencies: This work was supported by grants fromFondsSpéciaux de Recherche(FSR; IONS-FSR16 DUQUE) andAction deRecherche Concertée-Parkinson(ARC; M1.21303.001) of theUniversité catholique de Louvain, the Belgian National Funds for Scien-tific Research (FRS-FNRS: MIS F.4512.14), andFondation MédicaleReine Elisabeth. During the research project, E.W. was a doctoral stu-dent supported by the L’Oréal-UNESCO“For Women in Science”pro-gram and the FRS–FNRS (1.A938.18). C.Q. and G.D. were postdoctoralfellows supported by the FRS–FNRS (1.B358.18, 1.B134.18).
publishDate 2022
dc.date.none.fl_str_mv 2022-12-01
2022-12-01T00:00:00Z
2023-09-02T00:31:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/144402
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 0885-3185
PURE: 46803897
https://doi.org/10.1002/mds.29214
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