ATYPICAL FIBROXANTHOMA: CLINICOPATHOLOGICAL REVIEW
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.29021/spdv.73.1.345 |
Resumo: | Introduction: Atypical fibroxanthoma (AFX) is a rare cutaneous tumor without a completely defined histogenesis which frequently develops on head and neck of elderly people. Its diagnosis is histological, of exclusion with other tumors with identical morphology. Despite its classical benign behavior some rare cases reporting distant metastasis classified it on intermediate malignancy.Material and methods: We preformed a retrospective analysis with purpose of reviewing the AFX diagnosis made in our department between 2008 and 2014. We analyzed demographic, clinical, histological and immunohistochemical data and also surgical treatment and recurrence.Results: We obtained 12 cases of AFX, 11 males and 1 female, the youngest was 25 years old and the others had a median age of 76 years. The lesions were nodules or tumors with 1.9cm median size, all of them located on the head. Histology revealed well defined lesions with atypical pleomorphic cells and frequent solar elastosis, classified as mix variant (spindle and histiocytic cells) in all cases. Immunohistochemical study showed positivity for vimentin and negativity for cytokeratins and S100 protein in all cases and CD10 and CD99 were frequently positive. Surgical excision was performed in 10 cases with 10% rate of recurrence during 3 years of median follow-up.Conclusions: These results were similar with other published series. This tumor is clinically unspecified and histologically undifferentiated and so immunohistochemistry is essential for diagnosis, however, for now, available makers are not sufficiently specific. Despite its good prognosis in most cases clinical surveillance is recommended. |
id |
RCAP_4725d1e83de228e24733d9152806cfcb |
---|---|
oai_identifier_str |
oai:ojs.revista.spdv.com.pt:article/345 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
ATYPICAL FIBROXANTHOMA: CLINICOPATHOLOGICAL REVIEWFIBROXANTOMA ATÍPICO: REVISÃO CLÍNICO-PATOLÓGICAAtypical fibroxanthomaHistiocytomamalignant fibrousFibroxantoma atípicoFibrohistiocitoma maligno.Introduction: Atypical fibroxanthoma (AFX) is a rare cutaneous tumor without a completely defined histogenesis which frequently develops on head and neck of elderly people. Its diagnosis is histological, of exclusion with other tumors with identical morphology. Despite its classical benign behavior some rare cases reporting distant metastasis classified it on intermediate malignancy.Material and methods: We preformed a retrospective analysis with purpose of reviewing the AFX diagnosis made in our department between 2008 and 2014. We analyzed demographic, clinical, histological and immunohistochemical data and also surgical treatment and recurrence.Results: We obtained 12 cases of AFX, 11 males and 1 female, the youngest was 25 years old and the others had a median age of 76 years. The lesions were nodules or tumors with 1.9cm median size, all of them located on the head. Histology revealed well defined lesions with atypical pleomorphic cells and frequent solar elastosis, classified as mix variant (spindle and histiocytic cells) in all cases. Immunohistochemical study showed positivity for vimentin and negativity for cytokeratins and S100 protein in all cases and CD10 and CD99 were frequently positive. Surgical excision was performed in 10 cases with 10% rate of recurrence during 3 years of median follow-up.Conclusions: These results were similar with other published series. This tumor is clinically unspecified and histologically undifferentiated and so immunohistochemistry is essential for diagnosis, however, for now, available makers are not sufficiently specific. Despite its good prognosis in most cases clinical surveillance is recommended.Introdução: O fibroxantoma atípico (FXA) é um tumor raro de histogénese indeterminada mais frequente em idosos nas áreas fotoexpostas da cabeça e pescoço. Trata-se de um tumor indiferenciado sendo o seu diagnóstico histológico de exclusão. Apesar de classicamente indolente, os casos descritos associados a metastização atribuem-lhe uma malignidade intermédia.Material e métodos: Foi objetivo deste estudo retrospetivo rever e caracterizar os casos de FXA diagnosticados no nosso serviço entre 2008 e 2014. Foram avaliadas variáveis demográficas, clínicas, dados histológicos, imunohistoquímicos, terapêutica cirúrgica e recidiva.Resultados: Foram diagnosticados 12 casos de FXA, 11 do sexo masculino e 1 do sexo feminino, o mais novo com 25 anos e os restantes com idade média de 76 anos. Apresentaram-se como nódulos/tumores com diâmetro médio de 1,9cm, todos localizados na cabeça. Histologicamente revelaram-se lesões bem delimitadas com grande atipia citológica e elastose solar frequente, todas classificadas na variante mista (células fusiformes e histiocitárias). Na imunohistoquímica verificou-se positividade para a vimentina e negatividade para as citoqueratinas e proteína S100 em todos os casos, sendo positivos o CD10 e CD99 na maioria dos casos. A terapêutica foi cirúrgica com excisão radical da lesão em 10 doentes, sendo a recidiva local de 10% num seguimento médio de 3 anos.Conclusões: Os resultados obtidos foram concordantes com outras séries da literatura. Dada a clínica inespecífica e tratando-se de um tumor histologicamente indiferenciado a imunohistoquímica é essencial, não existindo ainda marcadores suficientemente específicos. Apesar do bom prognóstico na maioria dos casos a vigilância destes doentes é recomendada.Sociedade Portuguesa de Dermatologia e Venereologia2015-06-06T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.73.1.345oai:ojs.revista.spdv.com.pt:article/345Journal of the Portuguese Society of Dermatology and Venereology; Vol 73 No 1 (2015): Janeiro - Março; 71-77Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 73 n. 1 (2015): Janeiro - Março; 71-772182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/345https://doi.org/10.29021/spdv.73.1.345https://revista.spdv.com.pt/index.php/spdv/article/view/345/314António, Ana MartaAlves, JoãoMatos, DiogoGoulão, JoãoBártolo, Elvirainfo:eu-repo/semantics/openAccess2022-10-06T12:34:51Zoai:ojs.revista.spdv.com.pt:article/345Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:10:51.398112Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
ATYPICAL FIBROXANTHOMA: CLINICOPATHOLOGICAL REVIEW FIBROXANTOMA ATÍPICO: REVISÃO CLÍNICO-PATOLÓGICA |
title |
ATYPICAL FIBROXANTHOMA: CLINICOPATHOLOGICAL REVIEW |
spellingShingle |
ATYPICAL FIBROXANTHOMA: CLINICOPATHOLOGICAL REVIEW António, Ana Marta Atypical fibroxanthoma Histiocytoma malignant fibrous Fibroxantoma atípico Fibrohistiocitoma maligno. |
title_short |
ATYPICAL FIBROXANTHOMA: CLINICOPATHOLOGICAL REVIEW |
title_full |
ATYPICAL FIBROXANTHOMA: CLINICOPATHOLOGICAL REVIEW |
title_fullStr |
ATYPICAL FIBROXANTHOMA: CLINICOPATHOLOGICAL REVIEW |
title_full_unstemmed |
ATYPICAL FIBROXANTHOMA: CLINICOPATHOLOGICAL REVIEW |
title_sort |
ATYPICAL FIBROXANTHOMA: CLINICOPATHOLOGICAL REVIEW |
author |
António, Ana Marta |
author_facet |
António, Ana Marta Alves, João Matos, Diogo Goulão, João Bártolo, Elvira |
author_role |
author |
author2 |
Alves, João Matos, Diogo Goulão, João Bártolo, Elvira |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
António, Ana Marta Alves, João Matos, Diogo Goulão, João Bártolo, Elvira |
dc.subject.por.fl_str_mv |
Atypical fibroxanthoma Histiocytoma malignant fibrous Fibroxantoma atípico Fibrohistiocitoma maligno. |
topic |
Atypical fibroxanthoma Histiocytoma malignant fibrous Fibroxantoma atípico Fibrohistiocitoma maligno. |
description |
Introduction: Atypical fibroxanthoma (AFX) is a rare cutaneous tumor without a completely defined histogenesis which frequently develops on head and neck of elderly people. Its diagnosis is histological, of exclusion with other tumors with identical morphology. Despite its classical benign behavior some rare cases reporting distant metastasis classified it on intermediate malignancy.Material and methods: We preformed a retrospective analysis with purpose of reviewing the AFX diagnosis made in our department between 2008 and 2014. We analyzed demographic, clinical, histological and immunohistochemical data and also surgical treatment and recurrence.Results: We obtained 12 cases of AFX, 11 males and 1 female, the youngest was 25 years old and the others had a median age of 76 years. The lesions were nodules or tumors with 1.9cm median size, all of them located on the head. Histology revealed well defined lesions with atypical pleomorphic cells and frequent solar elastosis, classified as mix variant (spindle and histiocytic cells) in all cases. Immunohistochemical study showed positivity for vimentin and negativity for cytokeratins and S100 protein in all cases and CD10 and CD99 were frequently positive. Surgical excision was performed in 10 cases with 10% rate of recurrence during 3 years of median follow-up.Conclusions: These results were similar with other published series. This tumor is clinically unspecified and histologically undifferentiated and so immunohistochemistry is essential for diagnosis, however, for now, available makers are not sufficiently specific. Despite its good prognosis in most cases clinical surveillance is recommended. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06-06T00:00:00Z |
dc.type.driver.fl_str_mv |
journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.29021/spdv.73.1.345 oai:ojs.revista.spdv.com.pt:article/345 |
url |
https://doi.org/10.29021/spdv.73.1.345 |
identifier_str_mv |
oai:ojs.revista.spdv.com.pt:article/345 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revista.spdv.com.pt/index.php/spdv/article/view/345 https://doi.org/10.29021/spdv.73.1.345 https://revista.spdv.com.pt/index.php/spdv/article/view/345/314 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
dc.source.none.fl_str_mv |
Journal of the Portuguese Society of Dermatology and Venereology; Vol 73 No 1 (2015): Janeiro - Março; 71-77 Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 73 n. 1 (2015): Janeiro - Março; 71-77 2182-2409 2182-2395 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799130565016813568 |