Amniocentesis in HIV Pregnant Women: 16 Years of Experience
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/1830 |
Resumo: | The iatrogenic risk of HIV vertical transmission, calculated in initial epidemiologic studies, seemed to counterindicate invasive prenatal diagnosis (PND) procedures. The implementation of highly active antiretroviral therapy (HAART) represented a turning point in PND management, owing to a rapid and effective reduction of maternal viral load (VL). In the present study, we identified cases of vertical transmission in HIV-infected pregnant women who did amniocentesis in the second trimester of pregnancy (n = 27), from 1996 to 2011. We divided our sample into Group A--women under HAART when submitted to amniocentesis (n = 20) and Group B--women without antiretroviral therapy before amniocentesis (n = 7). We had 1 case of vertical transmission in Group B. Preconceptional or early first trimester HIV serology is essential to avoid performing an amniocentesis without antiretroviral therapy or viral suppression. When there is an indication for amniocentesis in an HIV-infected pregnant woman, it should be done if the patient is on HAART and, if possible, when VL is undetectable. Nowadays, with combined first trimester screening test to select pregnancies with high risk of aneuploidies, advanced maternal age is a less frequent indication to perform PND invasive procedures, representing an outstanding gain in prenatal diagnosis of this population. |
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Amniocentesis in HIV Pregnant Women: 16 Years of ExperienceMAC GINMAC PEDMAC MED MAFAmniocentesis/adverse effectsAmniocentesis/methodsAmniocentesis/statistics & numerical dataAnti-Retroviral AgentsAnti-Retroviral Therapy, Highly ActiveCohort StudiesHIV InfectionsIatrogenic DiseaseInfectious Disease Transmission, VerticalPregnancyPregnancy Complications, InfectionsPregnancy Trimester, SecondThe iatrogenic risk of HIV vertical transmission, calculated in initial epidemiologic studies, seemed to counterindicate invasive prenatal diagnosis (PND) procedures. The implementation of highly active antiretroviral therapy (HAART) represented a turning point in PND management, owing to a rapid and effective reduction of maternal viral load (VL). In the present study, we identified cases of vertical transmission in HIV-infected pregnant women who did amniocentesis in the second trimester of pregnancy (n = 27), from 1996 to 2011. We divided our sample into Group A--women under HAART when submitted to amniocentesis (n = 20) and Group B--women without antiretroviral therapy before amniocentesis (n = 7). We had 1 case of vertical transmission in Group B. Preconceptional or early first trimester HIV serology is essential to avoid performing an amniocentesis without antiretroviral therapy or viral suppression. When there is an indication for amniocentesis in an HIV-infected pregnant woman, it should be done if the patient is on HAART and, if possible, when VL is undetectable. Nowadays, with combined first trimester screening test to select pregnancies with high risk of aneuploidies, advanced maternal age is a less frequent indication to perform PND invasive procedures, representing an outstanding gain in prenatal diagnosis of this population.Hindawi Publishing CorporationRepositório do Centro Hospitalar Universitário de Lisboa Central, EPESimões, MMarques, CGonçalves, APereira, APCorreia, JCastela, JGuerreiro, C2014-06-19T14:30:14Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/1830engInfect Dis Obstet Gynecol. 2013;2013:914272. doi: 10.1155/2013/914272. Epub 2013 Jul 21info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:33:31Zoai:repositorio.chlc.min-saude.pt:10400.17/1830Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:19:14.669804Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Amniocentesis in HIV Pregnant Women: 16 Years of Experience |
title |
Amniocentesis in HIV Pregnant Women: 16 Years of Experience |
spellingShingle |
Amniocentesis in HIV Pregnant Women: 16 Years of Experience Simões, M MAC GIN MAC PED MAC MED MAF Amniocentesis/adverse effects Amniocentesis/methods Amniocentesis/statistics & numerical data Anti-Retroviral Agents Anti-Retroviral Therapy, Highly Active Cohort Studies HIV Infections Iatrogenic Disease Infectious Disease Transmission, Vertical Pregnancy Pregnancy Complications, Infections Pregnancy Trimester, Second |
title_short |
Amniocentesis in HIV Pregnant Women: 16 Years of Experience |
title_full |
Amniocentesis in HIV Pregnant Women: 16 Years of Experience |
title_fullStr |
Amniocentesis in HIV Pregnant Women: 16 Years of Experience |
title_full_unstemmed |
Amniocentesis in HIV Pregnant Women: 16 Years of Experience |
title_sort |
Amniocentesis in HIV Pregnant Women: 16 Years of Experience |
author |
Simões, M |
author_facet |
Simões, M Marques, C Gonçalves, A Pereira, AP Correia, J Castela, J Guerreiro, C |
author_role |
author |
author2 |
Marques, C Gonçalves, A Pereira, AP Correia, J Castela, J Guerreiro, C |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Simões, M Marques, C Gonçalves, A Pereira, AP Correia, J Castela, J Guerreiro, C |
dc.subject.por.fl_str_mv |
MAC GIN MAC PED MAC MED MAF Amniocentesis/adverse effects Amniocentesis/methods Amniocentesis/statistics & numerical data Anti-Retroviral Agents Anti-Retroviral Therapy, Highly Active Cohort Studies HIV Infections Iatrogenic Disease Infectious Disease Transmission, Vertical Pregnancy Pregnancy Complications, Infections Pregnancy Trimester, Second |
topic |
MAC GIN MAC PED MAC MED MAF Amniocentesis/adverse effects Amniocentesis/methods Amniocentesis/statistics & numerical data Anti-Retroviral Agents Anti-Retroviral Therapy, Highly Active Cohort Studies HIV Infections Iatrogenic Disease Infectious Disease Transmission, Vertical Pregnancy Pregnancy Complications, Infections Pregnancy Trimester, Second |
description |
The iatrogenic risk of HIV vertical transmission, calculated in initial epidemiologic studies, seemed to counterindicate invasive prenatal diagnosis (PND) procedures. The implementation of highly active antiretroviral therapy (HAART) represented a turning point in PND management, owing to a rapid and effective reduction of maternal viral load (VL). In the present study, we identified cases of vertical transmission in HIV-infected pregnant women who did amniocentesis in the second trimester of pregnancy (n = 27), from 1996 to 2011. We divided our sample into Group A--women under HAART when submitted to amniocentesis (n = 20) and Group B--women without antiretroviral therapy before amniocentesis (n = 7). We had 1 case of vertical transmission in Group B. Preconceptional or early first trimester HIV serology is essential to avoid performing an amniocentesis without antiretroviral therapy or viral suppression. When there is an indication for amniocentesis in an HIV-infected pregnant woman, it should be done if the patient is on HAART and, if possible, when VL is undetectable. Nowadays, with combined first trimester screening test to select pregnancies with high risk of aneuploidies, advanced maternal age is a less frequent indication to perform PND invasive procedures, representing an outstanding gain in prenatal diagnosis of this population. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2013-01-01T00:00:00Z 2014-06-19T14:30:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/1830 |
url |
http://hdl.handle.net/10400.17/1830 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Infect Dis Obstet Gynecol. 2013;2013:914272. doi: 10.1155/2013/914272. Epub 2013 Jul 21 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799131289922568192 |