Evaluation of Antipsychotic Drugs’ Stability in Oral Fluid Samples

Detalhes bibliográficos
Autor(a) principal: Gameiro, Carina
Data de Publicação: 2023
Outros Autores: Gonçalves, Joana, Soares, Sofia, Rosado, Tiago, Araújo, André R. T. S., Passarinha, Luís A., Barroso, Mário, Gallardo, Eugénia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/154835
Resumo: Funding Information: This work is supported by projects LA/P/0140/2020 (i4HB), being carried out by National Funds of the Foundation for Science and Technology (FCT) and co-financed by community funds. Publisher Copyright: © 2023 by the authors.
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spelling Evaluation of Antipsychotic Drugs’ Stability in Oral Fluid Samplesantipsychoticsdried saliva spotsGC-MS/MSoral fluidstabilityAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic ChemistryFunding Information: This work is supported by projects LA/P/0140/2020 (i4HB), being carried out by National Funds of the Foundation for Science and Technology (FCT) and co-financed by community funds. Publisher Copyright: © 2023 by the authors.Antipsychotics have narrow therapeutic windows, and their monitoring in biological fluids is therefore important; consequently, stability in those fluids must be investigated during method development and validation. This work evaluates the stability of chlorpromazine, levomepromazine, cyamemazine, clozapine, haloperidol, and quetiapine in oral fluid (OF) samples, using the dried saliva spots (DSS) sampling approach and gas chromatography coupled to tandem mass spectrometry. Since many parameters can influence the stability of the target analytes, design of experiments was adopted to check the crucial factors that affect that stability in a multivariate fashion. The studied parameters were the presence of preservatives at different concentrations, temperature, light, and time. It was possible to observe that antipsychotic stability improved when OF samples in DSS were stored at 4 °C, with a low ascorbic acid concentration, and in the absence of light. With these conditions, chlorpromazine and quetiapine were stable for 14 days, clozapine and haloperidol were stable for 28 days, levomepromazine remained stable for 44 days, and cyamemazine was stable for the entire monitored period (146 days). This is the first study that evaluates the stability of these antipsychotics in OF samples after application to DSS cards.UCIBIO - Applied Molecular Biosciences UnitDQ - Departamento de QuímicaRUNGameiro, CarinaGonçalves, JoanaSoares, SofiaRosado, TiagoAraújo, André R. T. S.Passarinha, Luís A.Barroso, MárioGallardo, Eugénia2023-07-04T22:15:25Z2023-02-212023-02-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/154835eng1420-3049PURE: 64820001https://doi.org/10.3390/molecules28052030info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:37:17Zoai:run.unl.pt:10362/154835Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:46.811946Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evaluation of Antipsychotic Drugs’ Stability in Oral Fluid Samples
title Evaluation of Antipsychotic Drugs’ Stability in Oral Fluid Samples
spellingShingle Evaluation of Antipsychotic Drugs’ Stability in Oral Fluid Samples
Gameiro, Carina
antipsychotics
dried saliva spots
GC-MS/MS
oral fluid
stability
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
title_short Evaluation of Antipsychotic Drugs’ Stability in Oral Fluid Samples
title_full Evaluation of Antipsychotic Drugs’ Stability in Oral Fluid Samples
title_fullStr Evaluation of Antipsychotic Drugs’ Stability in Oral Fluid Samples
title_full_unstemmed Evaluation of Antipsychotic Drugs’ Stability in Oral Fluid Samples
title_sort Evaluation of Antipsychotic Drugs’ Stability in Oral Fluid Samples
author Gameiro, Carina
author_facet Gameiro, Carina
Gonçalves, Joana
Soares, Sofia
Rosado, Tiago
Araújo, André R. T. S.
Passarinha, Luís A.
Barroso, Mário
Gallardo, Eugénia
author_role author
author2 Gonçalves, Joana
Soares, Sofia
Rosado, Tiago
Araújo, André R. T. S.
Passarinha, Luís A.
Barroso, Mário
Gallardo, Eugénia
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Gameiro, Carina
Gonçalves, Joana
Soares, Sofia
Rosado, Tiago
Araújo, André R. T. S.
Passarinha, Luís A.
Barroso, Mário
Gallardo, Eugénia
dc.subject.por.fl_str_mv antipsychotics
dried saliva spots
GC-MS/MS
oral fluid
stability
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
topic antipsychotics
dried saliva spots
GC-MS/MS
oral fluid
stability
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
description Funding Information: This work is supported by projects LA/P/0140/2020 (i4HB), being carried out by National Funds of the Foundation for Science and Technology (FCT) and co-financed by community funds. Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-04T22:15:25Z
2023-02-21
2023-02-21T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154835
url http://hdl.handle.net/10362/154835
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1420-3049
PURE: 64820001
https://doi.org/10.3390/molecules28052030
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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