Aging effect on functionalized silver-based nanocoating braided coronary stents
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/68607 |
Resumo: | A previously developed fiber-based polyester (PES) stent, with mechanical properties comparable to commercial nitinol stents, was coated with metallic silver (Ag0) and silver oxides (AgxO) thin films through direct current (DC) magnetron sputtering. Ag0 and AgxO coatings provide antimicrobial properties to the stents to minimize the occurrence of coronary stent infections. Nevertheless, the stent interacts with the atmosphere and then with the biological fluids and may lead to the generation of silver species with diminished antimicrobial efficiency and/or prone to induce cytotoxicity. Therefore, stent coating nanostructures aged 3 months were thoroughly analyzed by X-ray photoelectron spectroscopy (XPS) and their antimicrobial and cytotoxicity properties were assessed. Aging led to the presence of silver carbonate and bicarbonate as well as chemisorbed oxygen species in Ag0 and AgxO coatings. Bactericidal efficacy was tested against an important nosocomial bacterium, particularly associated to indwelling devices: Staphylococcus epidermidis. Aged Ag0 and AgxO coating presented a Log reduction of 1 and 2 at their surface; respectively. However, aged stents were able to induce a Log reduction of 2 (Ag0) and 4 (AgxO) on the surrounding medium. Only aged AgxO stent was able to provide a mild reduction of the bacterium at its surface and a clear antimicrobial effect (Log reduction >3) within its vicinity. More importantly, both aged Ag0 and AgxO stents were shown to be compatible with fibroblasts cells indicating that they can be safely used as indwelling devices, despite the aging effect |
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Aging effect on functionalized silver-based nanocoating braided coronary stentsStentSilverTextileDirect current magnetron sputteringX-ray photoelectron spectroscopyBactericidalCytotoxicityEngenharia e Tecnologia::Engenharia dos MateriaisScience & TechnologyA previously developed fiber-based polyester (PES) stent, with mechanical properties comparable to commercial nitinol stents, was coated with metallic silver (Ag0) and silver oxides (AgxO) thin films through direct current (DC) magnetron sputtering. Ag0 and AgxO coatings provide antimicrobial properties to the stents to minimize the occurrence of coronary stent infections. Nevertheless, the stent interacts with the atmosphere and then with the biological fluids and may lead to the generation of silver species with diminished antimicrobial efficiency and/or prone to induce cytotoxicity. Therefore, stent coating nanostructures aged 3 months were thoroughly analyzed by X-ray photoelectron spectroscopy (XPS) and their antimicrobial and cytotoxicity properties were assessed. Aging led to the presence of silver carbonate and bicarbonate as well as chemisorbed oxygen species in Ag0 and AgxO coatings. Bactericidal efficacy was tested against an important nosocomial bacterium, particularly associated to indwelling devices: Staphylococcus epidermidis. Aged Ag0 and AgxO coating presented a Log reduction of 1 and 2 at their surface; respectively. However, aged stents were able to induce a Log reduction of 2 (Ag0) and 4 (AgxO) on the surrounding medium. Only aged AgxO stent was able to provide a mild reduction of the bacterium at its surface and a clear antimicrobial effect (Log reduction >3) within its vicinity. More importantly, both aged Ag0 and AgxO stents were shown to be compatible with fibroblasts cells indicating that they can be safely used as indwelling devices, despite the aging effectThis work was funded by FEDER funds through the Operational Competitiveness ProgramCOMPETE and by National Funds through Fundacao para a Ciencia e Tecnologia (FCT)-under the projects PTDC/CTM-TEX/28295/2017 and UID/CTM/00264/2019.MDPI PublishingUniversidade do MinhoRebelo, Rita Daniela NogueiraPadrão, JorgeFernandes, Margarida Maria MacedoCarvalho, S.Henriques, MarianaZille, AndreaFangueiro, Raúl2020-122020-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/68607engRebelo, R.; Padrão, J.; Fernandes, M.M.; Carvalho, S.; Henriques, M.; Zille, A.; Fangueiro, R. Aging Effect on Functionalized Silver-Based Nanocoating Braided Coronary Stents. Coatings 2020, 10, 1234.2079-641210.3390/coatings10121234https://www.mdpi.com/2079-6412/10/12/1234#citeinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:33:35Zoai:repositorium.sdum.uminho.pt:1822/68607Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:29:09.230421Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Aging effect on functionalized silver-based nanocoating braided coronary stents |
title |
Aging effect on functionalized silver-based nanocoating braided coronary stents |
spellingShingle |
Aging effect on functionalized silver-based nanocoating braided coronary stents Rebelo, Rita Daniela Nogueira Stent Silver Textile Direct current magnetron sputtering X-ray photoelectron spectroscopy Bactericidal Cytotoxicity Engenharia e Tecnologia::Engenharia dos Materiais Science & Technology |
title_short |
Aging effect on functionalized silver-based nanocoating braided coronary stents |
title_full |
Aging effect on functionalized silver-based nanocoating braided coronary stents |
title_fullStr |
Aging effect on functionalized silver-based nanocoating braided coronary stents |
title_full_unstemmed |
Aging effect on functionalized silver-based nanocoating braided coronary stents |
title_sort |
Aging effect on functionalized silver-based nanocoating braided coronary stents |
author |
Rebelo, Rita Daniela Nogueira |
author_facet |
Rebelo, Rita Daniela Nogueira Padrão, Jorge Fernandes, Margarida Maria Macedo Carvalho, S. Henriques, Mariana Zille, Andrea Fangueiro, Raúl |
author_role |
author |
author2 |
Padrão, Jorge Fernandes, Margarida Maria Macedo Carvalho, S. Henriques, Mariana Zille, Andrea Fangueiro, Raúl |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Rebelo, Rita Daniela Nogueira Padrão, Jorge Fernandes, Margarida Maria Macedo Carvalho, S. Henriques, Mariana Zille, Andrea Fangueiro, Raúl |
dc.subject.por.fl_str_mv |
Stent Silver Textile Direct current magnetron sputtering X-ray photoelectron spectroscopy Bactericidal Cytotoxicity Engenharia e Tecnologia::Engenharia dos Materiais Science & Technology |
topic |
Stent Silver Textile Direct current magnetron sputtering X-ray photoelectron spectroscopy Bactericidal Cytotoxicity Engenharia e Tecnologia::Engenharia dos Materiais Science & Technology |
description |
A previously developed fiber-based polyester (PES) stent, with mechanical properties comparable to commercial nitinol stents, was coated with metallic silver (Ag0) and silver oxides (AgxO) thin films through direct current (DC) magnetron sputtering. Ag0 and AgxO coatings provide antimicrobial properties to the stents to minimize the occurrence of coronary stent infections. Nevertheless, the stent interacts with the atmosphere and then with the biological fluids and may lead to the generation of silver species with diminished antimicrobial efficiency and/or prone to induce cytotoxicity. Therefore, stent coating nanostructures aged 3 months were thoroughly analyzed by X-ray photoelectron spectroscopy (XPS) and their antimicrobial and cytotoxicity properties were assessed. Aging led to the presence of silver carbonate and bicarbonate as well as chemisorbed oxygen species in Ag0 and AgxO coatings. Bactericidal efficacy was tested against an important nosocomial bacterium, particularly associated to indwelling devices: Staphylococcus epidermidis. Aged Ag0 and AgxO coating presented a Log reduction of 1 and 2 at their surface; respectively. However, aged stents were able to induce a Log reduction of 2 (Ag0) and 4 (AgxO) on the surrounding medium. Only aged AgxO stent was able to provide a mild reduction of the bacterium at its surface and a clear antimicrobial effect (Log reduction >3) within its vicinity. More importantly, both aged Ag0 and AgxO stents were shown to be compatible with fibroblasts cells indicating that they can be safely used as indwelling devices, despite the aging effect |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12 2020-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/68607 |
url |
http://hdl.handle.net/1822/68607 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rebelo, R.; Padrão, J.; Fernandes, M.M.; Carvalho, S.; Henriques, M.; Zille, A.; Fangueiro, R. Aging Effect on Functionalized Silver-Based Nanocoating Braided Coronary Stents. Coatings 2020, 10, 1234. 2079-6412 10.3390/coatings10121234 https://www.mdpi.com/2079-6412/10/12/1234#cite |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI Publishing |
publisher.none.fl_str_mv |
MDPI Publishing |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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