Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship?
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6207 |
Resumo: | Introduction: The relationship between lymphomas and autoimmune diseases has been reported as bi-directional, however there is a few data in pediatric population. The aim of this work is to evaluate the prevalence of autoimmune diseases in children and adolescents with Hodgkin´s lymphoma followed in a Pediatric Oncology Unit.Material and Methods: By reviewing Hodgkin’s lymphomas data from the past 16 years (collected prospectively), an apparently large incidence of autoimmune diseases, mostly in female patients, was noted. We decided to do this retrospective study with an update on follow-up. Data analyzed: age, gender, autoimmune disease, temporal relation with lymphoma, lymphoma´s stage, histologic subtype and treatment.Results: Fifty-two cases were included, 7 (13.5%) of which, all female, had an autoimmune disease diagnosed previously, simultaneously or after lymphoma. Autoimmune diseases were: juvenile idiopathic arthritis, inflammatory bowel disease, Behçet´s disease, autoimmune hepatitis, systemic erythematosus lupus, Hashimoto´s thyroiditis and idiopathic thrombocytopenic purpura. The diagnosis was made after lymphoma in 4 patients, before in 2 and simultaneously in 1 patient. All cases, except the one with simultaneous diagnosis, are out of treatment and without oncologic disease relapse. No deaths were registered.Discussion: There was an important prevalence of autoimmune diseases in girls with Hodgkin´s lymphoma. We present data and discuss the possible causes based on a literature review.Conclusions: This relationship should be invoked, requiring more studies, especially in pediatric age. |
id |
RCAP_484ba1ccc5057dea11136420661e7bb1 |
---|---|
oai_identifier_str |
oai:ojs.www.actamedicaportuguesa.com:article/6207 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship?Linfoma de Hodgkin e Autoimunidade: Existirá uma Relação?Autoimmune DiseasesChildHodgkin Disease.CriançaDoenças AutoimunesDoença de Hodgkin.Introduction: The relationship between lymphomas and autoimmune diseases has been reported as bi-directional, however there is a few data in pediatric population. The aim of this work is to evaluate the prevalence of autoimmune diseases in children and adolescents with Hodgkin´s lymphoma followed in a Pediatric Oncology Unit.Material and Methods: By reviewing Hodgkin’s lymphomas data from the past 16 years (collected prospectively), an apparently large incidence of autoimmune diseases, mostly in female patients, was noted. We decided to do this retrospective study with an update on follow-up. Data analyzed: age, gender, autoimmune disease, temporal relation with lymphoma, lymphoma´s stage, histologic subtype and treatment.Results: Fifty-two cases were included, 7 (13.5%) of which, all female, had an autoimmune disease diagnosed previously, simultaneously or after lymphoma. Autoimmune diseases were: juvenile idiopathic arthritis, inflammatory bowel disease, Behçet´s disease, autoimmune hepatitis, systemic erythematosus lupus, Hashimoto´s thyroiditis and idiopathic thrombocytopenic purpura. The diagnosis was made after lymphoma in 4 patients, before in 2 and simultaneously in 1 patient. All cases, except the one with simultaneous diagnosis, are out of treatment and without oncologic disease relapse. No deaths were registered.Discussion: There was an important prevalence of autoimmune diseases in girls with Hodgkin´s lymphoma. We present data and discuss the possible causes based on a literature review.Conclusions: This relationship should be invoked, requiring more studies, especially in pediatric age.Introdução: A relação entre linfomas e doenças autoimunes é descrita na literatura como bidirecional, existindo poucos dados em idade pediátrica. Este trabalho tem como objetivo avaliar a prevalência de doenças autoimunes em crianças e adolescentes com linfoma de Hodgkin seguidos num Serviço de Oncologia Pediátrica.Material e Métodos: Ao rever a casuística do Serviço de linfomas de Hodgkin nos últimos 16 anos (dados colhidos prospetivamente), constatou-se uma incidência aparentemente elevada de doenças autoimunes nas raparigas pelo que se realizou um estudo retrospetivo, com atualização do seguimento fora de tratamento, relativamente à existência de doenças autoimunes. Avaliaram-se: idade, sexo, tipo de doença autoimune, relação temporal com o linfoma, estádio e grupo histológico do linfoma e terapêutica efetuada.Resultados: Incluíram-se 52 casos de linfoma de Hodgkin, dos quais sete (13,5%), todos do sexo feminino, tiveram uma doença autoimune diagnosticada previamente, em simultâneo ou posteriormente ao linfoma. As doenças autoimunes encontradas foram: artrite idiopática juvenil, doença inflamatória intestinal, doença de Behçet, hepatite autoimune, lúpus eritematoso sistémico, tiroidite de Hashimoto e púrpura trombocitopénica idiopática. Em quatro doentes o diagnóstico foi posterior ao linfoma, em dois, prévio, e num simultâneo. Todos os casos, exceto o diagnóstico simultâneo, estão fora de tratamento e sem recidiva da doença oncológica. Não se verificaram óbitos.Discussão: Verificou-se uma importante prevalência de doenças autoimunes nas raparigas com linfoma de Hodgkin. Apresentamos os dados e discutimos possíveis causas desta relação com base numa revisão bibliográfica.Conclusões: Esta associação deve ser evocada, sendo necessário mais estudos, sobretudo em idade pediátrica.Ordem dos Médicos2015-09-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6207oai:ojs.www.actamedicaportuguesa.com:article/6207Acta Médica Portuguesa; Vol. 28 No. 6 (2015): November-December; 749-753Acta Médica Portuguesa; Vol. 28 N.º 6 (2015): Novembro-Dezembro; 749-7531646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6207https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6207/4555https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6207/7871Jerónimo, MónicaSilva, SóniaBenedito, ManuelaBrito, Manuel Joãoinfo:eu-repo/semantics/openAccess2022-12-20T11:04:46Zoai:ojs.www.actamedicaportuguesa.com:article/6207Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:16.613892Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? Linfoma de Hodgkin e Autoimunidade: Existirá uma Relação? |
title |
Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? |
spellingShingle |
Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? Jerónimo, Mónica Autoimmune Diseases Child Hodgkin Disease. Criança Doenças Autoimunes Doença de Hodgkin. |
title_short |
Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? |
title_full |
Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? |
title_fullStr |
Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? |
title_full_unstemmed |
Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? |
title_sort |
Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? |
author |
Jerónimo, Mónica |
author_facet |
Jerónimo, Mónica Silva, Sónia Benedito, Manuela Brito, Manuel João |
author_role |
author |
author2 |
Silva, Sónia Benedito, Manuela Brito, Manuel João |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Jerónimo, Mónica Silva, Sónia Benedito, Manuela Brito, Manuel João |
dc.subject.por.fl_str_mv |
Autoimmune Diseases Child Hodgkin Disease. Criança Doenças Autoimunes Doença de Hodgkin. |
topic |
Autoimmune Diseases Child Hodgkin Disease. Criança Doenças Autoimunes Doença de Hodgkin. |
description |
Introduction: The relationship between lymphomas and autoimmune diseases has been reported as bi-directional, however there is a few data in pediatric population. The aim of this work is to evaluate the prevalence of autoimmune diseases in children and adolescents with Hodgkin´s lymphoma followed in a Pediatric Oncology Unit.Material and Methods: By reviewing Hodgkin’s lymphomas data from the past 16 years (collected prospectively), an apparently large incidence of autoimmune diseases, mostly in female patients, was noted. We decided to do this retrospective study with an update on follow-up. Data analyzed: age, gender, autoimmune disease, temporal relation with lymphoma, lymphoma´s stage, histologic subtype and treatment.Results: Fifty-two cases were included, 7 (13.5%) of which, all female, had an autoimmune disease diagnosed previously, simultaneously or after lymphoma. Autoimmune diseases were: juvenile idiopathic arthritis, inflammatory bowel disease, Behçet´s disease, autoimmune hepatitis, systemic erythematosus lupus, Hashimoto´s thyroiditis and idiopathic thrombocytopenic purpura. The diagnosis was made after lymphoma in 4 patients, before in 2 and simultaneously in 1 patient. All cases, except the one with simultaneous diagnosis, are out of treatment and without oncologic disease relapse. No deaths were registered.Discussion: There was an important prevalence of autoimmune diseases in girls with Hodgkin´s lymphoma. We present data and discuss the possible causes based on a literature review.Conclusions: This relationship should be invoked, requiring more studies, especially in pediatric age. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09-11 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6207 oai:ojs.www.actamedicaportuguesa.com:article/6207 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6207 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/6207 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6207 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6207/4555 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6207/7871 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 28 No. 6 (2015): November-December; 749-753 Acta Médica Portuguesa; Vol. 28 N.º 6 (2015): Novembro-Dezembro; 749-753 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799130643807862784 |