A retrospective study suggests that chronic insomnia behaves as a neurodegenerative disorder

Detalhes bibliográficos
Autor(a) principal: Neutel, Dulce
Data de Publicação: 2020
Outros Autores: Alvarenga, Tathiana, Reis, Cátia, Paiva, Teresa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/44080
Resumo: © 2020 Neutel D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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spelling A retrospective study suggests that chronic insomnia behaves as a neurodegenerative disorderInsomnia disorderPolysomnographyDegenerative process© 2020 Neutel D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Insomnia is a prevalent sleep disorder. We examined chronic insomnia in terms of subjective and objective measures, according to self-reported duration of disorder. 443 patients were included from a sleep clinic diagnosed with chronic insomnia (ICSD3 criteria). Patients were retrospectively evaluated in terms of medical interview, sleep questionnaires, a standard polysomnography study, and subdivided in subgroups according to disorder duration. We compared patient’s results to a control group. Insomnia and control groups were significantly different in terms of TST, SE, SOL, N1 sleep, REM sleep, REM latency and number of REM episodes (p<0.05). For the group of ≤1 year of insomnia disorder all PSG parameters were statistically different from controls, except N2% and N3%, REM latency, and number of REM episodes. In the groups of 2 to 4 years, 10 to 19 years, and ≥ 20 years of insomnia we found the same differences except for REM sleep. On the contrary, in a subgroup analysis of 5 to 9 years of insomnia disorder duration, no differences to control group were found in TST, N1 or REM sleep to control group, adjusted for age. The polysomnographic sleep profile of chronic insomnia patients is different over time. It sketches an initial attempt of compensation in initial years of insomnia, which seems to disappear in long time chronic insomnia patients, as we usually see in others neurodegenerative disorders. Future studies are needed to clarify the natural history of chronic insomnia disorder and its behaviour as a neurodegenerative disorder.Longdom PublishingRepositório da Universidade de LisboaNeutel, DulceAlvarenga, TathianaReis, CátiaPaiva, Teresa2020-07-21T11:56:07Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/44080engJ Sleep Disord Ther 9:3102167-027710.35248/2167-0277.19.9.309.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:44:41Zoai:repositorio.ul.pt:10451/44080Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:56:40.524126Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A retrospective study suggests that chronic insomnia behaves as a neurodegenerative disorder
title A retrospective study suggests that chronic insomnia behaves as a neurodegenerative disorder
spellingShingle A retrospective study suggests that chronic insomnia behaves as a neurodegenerative disorder
Neutel, Dulce
Insomnia disorder
Polysomnography
Degenerative process
title_short A retrospective study suggests that chronic insomnia behaves as a neurodegenerative disorder
title_full A retrospective study suggests that chronic insomnia behaves as a neurodegenerative disorder
title_fullStr A retrospective study suggests that chronic insomnia behaves as a neurodegenerative disorder
title_full_unstemmed A retrospective study suggests that chronic insomnia behaves as a neurodegenerative disorder
title_sort A retrospective study suggests that chronic insomnia behaves as a neurodegenerative disorder
author Neutel, Dulce
author_facet Neutel, Dulce
Alvarenga, Tathiana
Reis, Cátia
Paiva, Teresa
author_role author
author2 Alvarenga, Tathiana
Reis, Cátia
Paiva, Teresa
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Neutel, Dulce
Alvarenga, Tathiana
Reis, Cátia
Paiva, Teresa
dc.subject.por.fl_str_mv Insomnia disorder
Polysomnography
Degenerative process
topic Insomnia disorder
Polysomnography
Degenerative process
description © 2020 Neutel D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-21T11:56:07Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/44080
url http://hdl.handle.net/10451/44080
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Sleep Disord Ther 9:310
2167-0277
10.35248/2167-0277.19.9.309.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Longdom Publishing
publisher.none.fl_str_mv Longdom Publishing
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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