Risk score to predict the outcome of patients with cerebral vein and dural sinus thrombosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/20403 |
Resumo: | This study was supported by grants from the ‘Fundação para a Ciência e Tecnologia’ (PRAXIS C/SAU/10248/1998) and the ‘Associação para o Desenvolvimento da Investigação da Doença Vascular Cerebral’. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Risk score to predict the outcome of patients with cerebral vein and dural sinus thrombosisDural sinusCerebral vein thrombosisOutcomeValidationRisk scoreThis study was supported by grants from the ‘Fundação para a Ciência e Tecnologia’ (PRAXIS C/SAU/10248/1998) and the ‘Associação para o Desenvolvimento da Investigação da Doença Vascular Cerebral’.BACKGROUND: Around 15% of patients die or become dependent after cerebral vein and dural sinus thrombosis (CVT). METHOD: We used the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) sample (624 patients, with a median follow-up time of 478 days) to develop a Cox proportional hazards regression model to predict outcome, dichotomised by a modified Rankin Scale score >2. From the model hazard ratios, a risk score was derived and a cut-off point selected. The model and the score were tested in 2 validation samples: (1) the prospective Cerebral Venous Thrombosis Portuguese Collaborative Study Group (VENOPORT) sample with 91 patients; (2) a sample of 169 consecutive CVT patients admitted to 5 ISCVT centres after the end of the ISCVT recruitment period. Sensitivity, specificity, c statistics and overall efficiency to predict outcome at 6 months were calculated. RESULTS: The model (hazard ratios: malignancy 4.53; coma 4.19; thrombosis of the deep venous system 3.03; mental status disturbance 2.18; male gender 1.60; intracranial haemorrhage 1.42) had overall efficiencies of 85.1, 84.4 and 90.0%, in the derivation sample and validation samples 1 and 2, respectively. Using the risk score (range from 0 to 9) with a cut-off of >or=3 points, overall efficiency was 85.4, 84.4 and 90.1% in the derivation sample and validation samples 1 and 2, respectively. Sensitivity and specificity in the combined samples were 96.1 and 13.6%, respectively. CONCLUSIONS: The CVT risk score has a good estimated overall rate of correct classifications in both validation samples, but its specificity is low. It can be used to avoid unnecessary or dangerous interventions in low-risk patients, and may help to identify high-risk CVT patients.Fundação para a Ciência e Tecnologia (PRAXIS C/SAU/10248/1998) ; Associação para o Desenvolvimento da Investigação da Doença Vascular CerebralKargerRepositório da Universidade de LisboaFerro, JoséBacelar-Nicolau, HelenaRodrigues, TeresaBacelar-Nicolau, LeonorCanhão, PatríciaCrassard, IsabelleBousser, Marie-GermaineDutra, Aurélio PimentaMassaro, AyrtonMackowiack-Cordiolani, Marie-AnneLeys, DidierFontes, JoãoStam, JanBarinagarrementeria, Fernando2015-11-06T10:50:36Z20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/20403engCerebrovasc Dis 2009;28:39–441015-9770http://dx.doi.org/10.1159/000215942metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:05:48Zoai:repositorio.ul.pt:10451/20403Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:38:25.658804Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Risk score to predict the outcome of patients with cerebral vein and dural sinus thrombosis |
| title |
Risk score to predict the outcome of patients with cerebral vein and dural sinus thrombosis |
| spellingShingle |
Risk score to predict the outcome of patients with cerebral vein and dural sinus thrombosis Ferro, José Dural sinus Cerebral vein thrombosis Outcome Validation Risk score |
| title_short |
Risk score to predict the outcome of patients with cerebral vein and dural sinus thrombosis |
| title_full |
Risk score to predict the outcome of patients with cerebral vein and dural sinus thrombosis |
| title_fullStr |
Risk score to predict the outcome of patients with cerebral vein and dural sinus thrombosis |
| title_full_unstemmed |
Risk score to predict the outcome of patients with cerebral vein and dural sinus thrombosis |
| title_sort |
Risk score to predict the outcome of patients with cerebral vein and dural sinus thrombosis |
| author |
Ferro, José |
| author_facet |
Ferro, José Bacelar-Nicolau, Helena Rodrigues, Teresa Bacelar-Nicolau, Leonor Canhão, Patrícia Crassard, Isabelle Bousser, Marie-Germaine Dutra, Aurélio Pimenta Massaro, Ayrton Mackowiack-Cordiolani, Marie-Anne Leys, Didier Fontes, João Stam, Jan Barinagarrementeria, Fernando |
| author_role |
author |
| author2 |
Bacelar-Nicolau, Helena Rodrigues, Teresa Bacelar-Nicolau, Leonor Canhão, Patrícia Crassard, Isabelle Bousser, Marie-Germaine Dutra, Aurélio Pimenta Massaro, Ayrton Mackowiack-Cordiolani, Marie-Anne Leys, Didier Fontes, João Stam, Jan Barinagarrementeria, Fernando |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Ferro, José Bacelar-Nicolau, Helena Rodrigues, Teresa Bacelar-Nicolau, Leonor Canhão, Patrícia Crassard, Isabelle Bousser, Marie-Germaine Dutra, Aurélio Pimenta Massaro, Ayrton Mackowiack-Cordiolani, Marie-Anne Leys, Didier Fontes, João Stam, Jan Barinagarrementeria, Fernando |
| dc.subject.por.fl_str_mv |
Dural sinus Cerebral vein thrombosis Outcome Validation Risk score |
| topic |
Dural sinus Cerebral vein thrombosis Outcome Validation Risk score |
| description |
This study was supported by grants from the ‘Fundação para a Ciência e Tecnologia’ (PRAXIS C/SAU/10248/1998) and the ‘Associação para o Desenvolvimento da Investigação da Doença Vascular Cerebral’. |
| publishDate |
2009 |
| dc.date.none.fl_str_mv |
2009 2009-01-01T00:00:00Z 2015-11-06T10:50:36Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/20403 |
| url |
http://hdl.handle.net/10451/20403 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Cerebrovasc Dis 2009;28:39–44 1015-9770 http://dx.doi.org/10.1159/000215942 |
| dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Karger |
| publisher.none.fl_str_mv |
Karger |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134283720294400 |