Characterization of PAN-based Activated Carbon Fibers with Deposited Metal-Nanoparticles for Enhanced Wound Healing

Detalhes bibliográficos
Autor(a) principal: Soares, Jéssica da Silva Gil
Data de Publicação: 2022
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/61730
Resumo: Tese de mestrado integrado, Engenharia Biomédica e Biofísica (Biofísica Médica e Fisiologia de Sistemas), 2022
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spelling Characterization of PAN-based Activated Carbon Fibers with Deposited Metal-Nanoparticles for Enhanced Wound Healingfibras de carbono ativadotratamento de feridasfibroblastosqueratinócitos HaCaTnanoparticulasTeses de mestrado - 2022Departamento de FísicaTese de mestrado integrado, Engenharia Biomédica e Biofísica (Biofísica Médica e Fisiologia de Sistemas), 2022The use of activated carbon fibers as antimicrobial dressings for wound healing is a promising addition to the portfolio of advanced wound dressings. While carbon fiber is known to be a biologically inert material, the addition of metal-nanoparticles is gaining popularity in dermatology owing to properties such as accelerated wound healing and antibacterial activity. This study aimed to characterize polyacrylonitrile (PAN)-based activated carbon fibers with deposited gold, silver, copper, palladium and platinum nanoparticles as a potential tool to improve the clinical outcome of patients suffering from skin wounds. Moreover, the three-dimensional scaffolds for skin tissue engineering can provide simultaneously support for the dermal fibroblasts and keratinocytes in addition to covering wounds and protecting against infection. The structural changes arising from the graphitization of PAN-based carbon fibers as well as the metal-nanoparticles deposition were explored using Dynamic Mechanical Analysis (DMA), Raman spectroscopy, Fourier Transform Infra-Red (FTIR) Spectroscopy, Scanning Electron Microscopy (SEM), Optic Contact Angle (OCA), and Zeta potential (EKA). Beyond the physicochemical properties of carbon fibers with deposited nanoparticles (CF-NPs), the degradation profile and cytotoxicity are also investigated. DMA showed that the scaffolds studied can meet the demand of tissue engineered materials with a Young’s modulus comparable to human skin. EKA successfully characterized the Zeta potential of textile CF-NPs. Raman and FTIR spectroscopy shown that the activation process altered the chemical functional groups of the non-activated samples by shifting their wavenumbers and intensities. The samples showed high hydrophobicity through the optical contact angle of water micro-droplets. SEM was used to determine that the PAN-based carbon fibers feature deposited metal-nanoparticles with diameters of 12-15nm. A study of the composition and dispersion properties of the samples was conducted using EDX analysis. A 4-week degradation test was conducted to determine how CF-NPs scaffolds deteriorate in three different mediums - PBS, SBF, and HCl. Finally, the cytotoxicity of CF-NPs was tested in keratinocytes HaCaT and fibroblast cells.Santos, Tiago Alexandre dosFerreira, Hugo AlexandreRepositório da Universidade de LisboaSoares, Jéssica da Silva Gil202220222025-10-30T00:00:00Z2022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10451/61730enginfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-15T01:19:08Zoai:repositorio.ul.pt:10451/61730Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:44:37.151269Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Characterization of PAN-based Activated Carbon Fibers with Deposited Metal-Nanoparticles for Enhanced Wound Healing
title Characterization of PAN-based Activated Carbon Fibers with Deposited Metal-Nanoparticles for Enhanced Wound Healing
spellingShingle Characterization of PAN-based Activated Carbon Fibers with Deposited Metal-Nanoparticles for Enhanced Wound Healing
Soares, Jéssica da Silva Gil
fibras de carbono ativado
tratamento de feridas
fibroblastos
queratinócitos HaCaT
nanoparticulas
Teses de mestrado - 2022
Departamento de Física
title_short Characterization of PAN-based Activated Carbon Fibers with Deposited Metal-Nanoparticles for Enhanced Wound Healing
title_full Characterization of PAN-based Activated Carbon Fibers with Deposited Metal-Nanoparticles for Enhanced Wound Healing
title_fullStr Characterization of PAN-based Activated Carbon Fibers with Deposited Metal-Nanoparticles for Enhanced Wound Healing
title_full_unstemmed Characterization of PAN-based Activated Carbon Fibers with Deposited Metal-Nanoparticles for Enhanced Wound Healing
title_sort Characterization of PAN-based Activated Carbon Fibers with Deposited Metal-Nanoparticles for Enhanced Wound Healing
author Soares, Jéssica da Silva Gil
author_facet Soares, Jéssica da Silva Gil
author_role author
dc.contributor.none.fl_str_mv Santos, Tiago Alexandre dos
Ferreira, Hugo Alexandre
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Soares, Jéssica da Silva Gil
dc.subject.por.fl_str_mv fibras de carbono ativado
tratamento de feridas
fibroblastos
queratinócitos HaCaT
nanoparticulas
Teses de mestrado - 2022
Departamento de Física
topic fibras de carbono ativado
tratamento de feridas
fibroblastos
queratinócitos HaCaT
nanoparticulas
Teses de mestrado - 2022
Departamento de Física
description Tese de mestrado integrado, Engenharia Biomédica e Biofísica (Biofísica Médica e Fisiologia de Sistemas), 2022
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022-01-01T00:00:00Z
2025-10-30T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/61730
url http://hdl.handle.net/10451/61730
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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