Pleiotropic and potentially beneficial effects of reactive oxygen species on the intracellular signaling pathways in endothelial cells

Detalhes bibliográficos
Autor(a) principal: Barvitenko, Nadezhda
Data de Publicação: 2021
Outros Autores: Skverchinskaya, Elisaveta, Lawen, Alfons, Matteucci, Elena, Saldanha, Carlota, Uras, Giuseppe, Manca, Alessia, Aslam, Muhammad, Pantaleo, Antonella
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49605
Resumo: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Pleiotropic and potentially beneficial effects of reactive oxygen species on the intracellular signaling pathways in endothelial cellsEndothelial cellEndothelial dysfunctionEndothelial paracellular permeabilityInsulin resistanceReactive oxygen species© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Endothelial cells (ECs) are exposed to molecular dioxygen and its derivative reactive oxygen species (ROS). ROS are now well established as important signaling messengers. Excessive production of ROS, however, results in oxidative stress, a significant contributor to the development of numerous diseases. Here, we analyze the experimental data and theoretical concepts concerning positive pro-survival effects of ROS on signaling pathways in endothelial cells (ECs). Our analysis of the available experimental data suggests possible positive roles of ROS in induction of pro-survival pathways, downstream of the Gi-protein-coupled receptors, which mimics insulin signaling and prevention or improvement of the endothelial dysfunction. It is, however, doubtful, whether ROS can contribute to the stabilization of the endothelial barrier.MDPIRepositório da Universidade de LisboaBarvitenko, NadezhdaSkverchinskaya, ElisavetaLawen, AlfonsMatteucci, ElenaSaldanha, CarlotaUras, GiuseppeManca, AlessiaAslam, MuhammadPantaleo, Antonella2021-09-23T15:33:16Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49605engAntioxidants (Basel). 2021 Jun 3;10(6):90410.3390/antiox100609042076-3921info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:32Zoai:repositorio.ul.pt:10451/49605Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:14.974520Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Pleiotropic and potentially beneficial effects of reactive oxygen species on the intracellular signaling pathways in endothelial cells
title Pleiotropic and potentially beneficial effects of reactive oxygen species on the intracellular signaling pathways in endothelial cells
spellingShingle Pleiotropic and potentially beneficial effects of reactive oxygen species on the intracellular signaling pathways in endothelial cells
Barvitenko, Nadezhda
Endothelial cell
Endothelial dysfunction
Endothelial paracellular permeability
Insulin resistance
Reactive oxygen species
title_short Pleiotropic and potentially beneficial effects of reactive oxygen species on the intracellular signaling pathways in endothelial cells
title_full Pleiotropic and potentially beneficial effects of reactive oxygen species on the intracellular signaling pathways in endothelial cells
title_fullStr Pleiotropic and potentially beneficial effects of reactive oxygen species on the intracellular signaling pathways in endothelial cells
title_full_unstemmed Pleiotropic and potentially beneficial effects of reactive oxygen species on the intracellular signaling pathways in endothelial cells
title_sort Pleiotropic and potentially beneficial effects of reactive oxygen species on the intracellular signaling pathways in endothelial cells
author Barvitenko, Nadezhda
author_facet Barvitenko, Nadezhda
Skverchinskaya, Elisaveta
Lawen, Alfons
Matteucci, Elena
Saldanha, Carlota
Uras, Giuseppe
Manca, Alessia
Aslam, Muhammad
Pantaleo, Antonella
author_role author
author2 Skverchinskaya, Elisaveta
Lawen, Alfons
Matteucci, Elena
Saldanha, Carlota
Uras, Giuseppe
Manca, Alessia
Aslam, Muhammad
Pantaleo, Antonella
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Barvitenko, Nadezhda
Skverchinskaya, Elisaveta
Lawen, Alfons
Matteucci, Elena
Saldanha, Carlota
Uras, Giuseppe
Manca, Alessia
Aslam, Muhammad
Pantaleo, Antonella
dc.subject.por.fl_str_mv Endothelial cell
Endothelial dysfunction
Endothelial paracellular permeability
Insulin resistance
Reactive oxygen species
topic Endothelial cell
Endothelial dysfunction
Endothelial paracellular permeability
Insulin resistance
Reactive oxygen species
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-09-23T15:33:16Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49605
url http://hdl.handle.net/10451/49605
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antioxidants (Basel). 2021 Jun 3;10(6):904
10.3390/antiox10060904
2076-3921
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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