Bilateral alternating auditory stimulations facilitate fear extinction and retrieval

Detalhes bibliográficos
Autor(a) principal: Boukezzi, S.
Data de Publicação: 2017
Outros Autores: Silva, C., Nazarian, B., Rousseau, P. F., Guedj, E., Valenzuela-Moguillansky, C., Khalfa, S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10071/15632
Resumo: Disruption of fear conditioning, its extinction and its retrieval are at the core of posttraumatic stress disorder (PTSD). Such deficits, especially fear extinction delay, disappear after alternating bilateral stimulations (BLS) during eye movement desensitization and reprocessing (EMDR) therapy. An animal model of fear recovery, based on auditory cued fear conditioning and extinction learning, recently showed that BLS facilitate fear extinction and fear extinction retrieval. Our goal was to determine if these previous results found in animals can be reproduced in humans. Twenty-two healthy participants took part in a classical fear conditioning, extinction, and extinction recall paradigm. Behavioral responses (fear expectations) as well as psychophysiological measures (skin conductance responses, SCRs) were recorded. The results showed a significant fear expectation decrease during fear extinction with BLS. Additionally, SCR for fear extinction retrieval were significantly lower with BLS. Our results demonstrate the importance of BLS to reduce negative emotions, and provide a successful model to further explore the neural mechanisms underlying the sole BLS effect in the EMDR.
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spelling Bilateral alternating auditory stimulations facilitate fear extinction and retrievalEMDRFear conditioningFear extinctionSkin conductanceStressDisruption of fear conditioning, its extinction and its retrieval are at the core of posttraumatic stress disorder (PTSD). Such deficits, especially fear extinction delay, disappear after alternating bilateral stimulations (BLS) during eye movement desensitization and reprocessing (EMDR) therapy. An animal model of fear recovery, based on auditory cued fear conditioning and extinction learning, recently showed that BLS facilitate fear extinction and fear extinction retrieval. Our goal was to determine if these previous results found in animals can be reproduced in humans. Twenty-two healthy participants took part in a classical fear conditioning, extinction, and extinction recall paradigm. Behavioral responses (fear expectations) as well as psychophysiological measures (skin conductance responses, SCRs) were recorded. The results showed a significant fear expectation decrease during fear extinction with BLS. Additionally, SCR for fear extinction retrieval were significantly lower with BLS. Our results demonstrate the importance of BLS to reduce negative emotions, and provide a successful model to further explore the neural mechanisms underlying the sole BLS effect in the EMDR.Frontiers Media S.A.2018-04-17T11:25:04Z2017-01-01T00:00:00Z20172019-03-25T18:34:23Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10071/15632eng1664-107810.3389/fpsyg.2017.00990Boukezzi, S.Silva, C.Nazarian, B.Rousseau, P. F.Guedj, E.Valenzuela-Moguillansky, C.Khalfa, S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-09T17:31:13Zoai:repositorio.iscte-iul.pt:10071/15632Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:14:01.761650Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bilateral alternating auditory stimulations facilitate fear extinction and retrieval
title Bilateral alternating auditory stimulations facilitate fear extinction and retrieval
spellingShingle Bilateral alternating auditory stimulations facilitate fear extinction and retrieval
Boukezzi, S.
EMDR
Fear conditioning
Fear extinction
Skin conductance
Stress
title_short Bilateral alternating auditory stimulations facilitate fear extinction and retrieval
title_full Bilateral alternating auditory stimulations facilitate fear extinction and retrieval
title_fullStr Bilateral alternating auditory stimulations facilitate fear extinction and retrieval
title_full_unstemmed Bilateral alternating auditory stimulations facilitate fear extinction and retrieval
title_sort Bilateral alternating auditory stimulations facilitate fear extinction and retrieval
author Boukezzi, S.
author_facet Boukezzi, S.
Silva, C.
Nazarian, B.
Rousseau, P. F.
Guedj, E.
Valenzuela-Moguillansky, C.
Khalfa, S.
author_role author
author2 Silva, C.
Nazarian, B.
Rousseau, P. F.
Guedj, E.
Valenzuela-Moguillansky, C.
Khalfa, S.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Boukezzi, S.
Silva, C.
Nazarian, B.
Rousseau, P. F.
Guedj, E.
Valenzuela-Moguillansky, C.
Khalfa, S.
dc.subject.por.fl_str_mv EMDR
Fear conditioning
Fear extinction
Skin conductance
Stress
topic EMDR
Fear conditioning
Fear extinction
Skin conductance
Stress
description Disruption of fear conditioning, its extinction and its retrieval are at the core of posttraumatic stress disorder (PTSD). Such deficits, especially fear extinction delay, disappear after alternating bilateral stimulations (BLS) during eye movement desensitization and reprocessing (EMDR) therapy. An animal model of fear recovery, based on auditory cued fear conditioning and extinction learning, recently showed that BLS facilitate fear extinction and fear extinction retrieval. Our goal was to determine if these previous results found in animals can be reproduced in humans. Twenty-two healthy participants took part in a classical fear conditioning, extinction, and extinction recall paradigm. Behavioral responses (fear expectations) as well as psychophysiological measures (skin conductance responses, SCRs) were recorded. The results showed a significant fear expectation decrease during fear extinction with BLS. Additionally, SCR for fear extinction retrieval were significantly lower with BLS. Our results demonstrate the importance of BLS to reduce negative emotions, and provide a successful model to further explore the neural mechanisms underlying the sole BLS effect in the EMDR.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01T00:00:00Z
2017
2018-04-17T11:25:04Z
2019-03-25T18:34:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10071/15632
url http://hdl.handle.net/10071/15632
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1664-1078
10.3389/fpsyg.2017.00990
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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