Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smolts

Detalhes bibliográficos
Autor(a) principal: Osório, João
Data de Publicação: 2022
Outros Autores: Stiller, Kevin T., Reiten, Britt‑Kristin, Kolarevic, Jelena, Johansen, Lill‑Heidi, Afonso, Fernando, Lazado, Carlo C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/24281
Resumo: Research Areas: Zoology
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spelling Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smoltsDisinfectionNasal immunityMucosal immunityOxidative stressRASResearch Areas: ZoologyBackground: Fish encounter oxidative stress several times during their lifetime, and it has a pervasive infuence on their health and welfare. One of the triggers of oxidative stress in fsh farming is the use of oxidative disinfectants to improve rearing conditions, especially in production systems employing recirculation technology. Here we report the physiological and morphological adaptive responses of Atlantic salmon (Salmo salar L.) post-smolts to intermit tent exposure to a potent oxidative agent peracetic acid (PAA). Fish reared in semi-commercial scale brackish water recirculating aquaculture system (RAS) were exposed to 1ppm PAA every 3days over 6weeks. Mucosal and systemic responses were profled before exposure, 22 and 45days during the intermittent PAA administration. Results: Oxidative stress was likely triggered as plasma antioxidant capacity increased signifcantly during the expo sure period. Adaptive stress response to the periodic oxidant challenge was likewise demonstrated in the changes in plasma glucose and lactate levels. PAA-induced alterations in the transcription of antioxidants, cytokines, heat shock pro teins and mucin genes showed a tissue-specifc pattern: downregulation was observed in the gills and olfactory rosette, upregulation occurred in the skin, and no substantial changes in the liver. Further, PAA exposure resulted in histological changes in key mucosal organs (i.e. olfactory rosette, skin and gills); pathological alterations were predominant in the gills where cases of epithelial lifting, hypertrophy and clubbing were prevalent. In addition, intermittent PAA administration resulted in an apparent overproduction of mucus in the nasal mucosa. Lastly, PAA did not dramatically alter the ability of salmon to mount a physiological stress response in the presence of a secondary stressor, though some subtle interfer ence was documented in the kinetics and magnitude of plasma cortisol and glucose response post-stress. Conclusions: The present study collectively demonstrated that intermittent oxidant exposure was a mild environ mental stressor that salmon could mount strong adaptive responses at systemic and mucosal levels. The results will be valuable in optimising the rearing conditions of post-smolts in RAS, especially in adopting water treatment strate gies that do not considerably interfere with fsh health and welfareBMCRepositório da Universidade de LisboaOsório, JoãoStiller, Kevin T.Reiten, Britt‑KristinKolarevic, JelenaJohansen, Lill‑HeidiAfonso, FernandoLazado, Carlo C.2022-05-11T20:55:48Z2022-01-042022-01-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24281engOsorio J, Stiller KT, Reiten BK, Kolarevic J, Johansen LH, Afonso F, Lazado CC. 2022. Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smolts. BMC Zoology, 7(1):1. DOI10.1186/s40850-021-00100-x10.1186/s40850-021-00100-x2056-3132info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:53:56Zoai:www.repository.utl.pt:10400.5/24281Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:08:22.114839Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smolts
title Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smolts
spellingShingle Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smolts
Osório, João
Disinfection
Nasal immunity
Mucosal immunity
Oxidative stress
RAS
title_short Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smolts
title_full Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smolts
title_fullStr Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smolts
title_full_unstemmed Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smolts
title_sort Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smolts
author Osório, João
author_facet Osório, João
Stiller, Kevin T.
Reiten, Britt‑Kristin
Kolarevic, Jelena
Johansen, Lill‑Heidi
Afonso, Fernando
Lazado, Carlo C.
author_role author
author2 Stiller, Kevin T.
Reiten, Britt‑Kristin
Kolarevic, Jelena
Johansen, Lill‑Heidi
Afonso, Fernando
Lazado, Carlo C.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Osório, João
Stiller, Kevin T.
Reiten, Britt‑Kristin
Kolarevic, Jelena
Johansen, Lill‑Heidi
Afonso, Fernando
Lazado, Carlo C.
dc.subject.por.fl_str_mv Disinfection
Nasal immunity
Mucosal immunity
Oxidative stress
RAS
topic Disinfection
Nasal immunity
Mucosal immunity
Oxidative stress
RAS
description Research Areas: Zoology
publishDate 2022
dc.date.none.fl_str_mv 2022-05-11T20:55:48Z
2022-01-04
2022-01-04T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/24281
url http://hdl.handle.net/10400.5/24281
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Osorio J, Stiller KT, Reiten BK, Kolarevic J, Johansen LH, Afonso F, Lazado CC. 2022. Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smolts. BMC Zoology, 7(1):1. DOI10.1186/s40850-021-00100-x
10.1186/s40850-021-00100-x
2056-3132
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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