Mucosal leishmaniasis caused by leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/117144 |
Resumo: | Background: Leishmania (Viannia) braziliensis is a parasite recognized as the most important etiologic agent of mucosal leishmaniasis (ML) in the New World. In Amazonia, seven different species of Leishmania, etiologic agents of human Cutaneous Leishmaniasis, have been described. Isolated cases of ML have been described for several different species of Leishmania: L. (V.) panamensis, L. (V.) guyanensis and L. (L.) amazonensis. Methodology: Leishmania species were characterized by polymerase chain reaction (PCR) of tissues taken from mucosal biopsies of Amazonian patients who were diagnosed with ML and treated at the Tropical Medicine Foundation of Amazonas (FMTAM) in Manaus, Amazonas state, Brazil. Samples were obtained retrospectively from the pathology laboratory and prospectively from patients attending the aforementioned tertiary care unit. Results: This study reports 46 cases of ML along with their geographical origin, 30 cases caused by L. (V.) braziliensis and 16 cases by L. (V.) guyanensis. This is the first record of ML cases in 16 different municipalities in the state of Amazonas and of simultaneous detection of both species in 4 municipalities of this state. It is also the first record of ML caused by L. (V.) guyanensis in the states of Pará, Acre, and Rondônia and cases of ML caused by L. (V.) braziliensis in the state of Rondônia. Conclusions/Significance: L. (V.) braziliensis is the predominant species that causes ML in the Amazon region. However, contrary to previous studies, L. (V.) guyanensis is also a significant causative agent of ML within the region. The clinical and epidemiological expression of ML in the Manaus region is similar to the rest of the country, although the majority of ML cases are found south of the Amazon River. |
id |
RCAP_4b123d561788dd02f82f569e6272f837 |
---|---|
oai_identifier_str |
oai:run.unl.pt:10362/117144 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Mucosal leishmaniasis caused by leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian AmazonInfectious DiseasesParasitologyGeneticsSDG 3 - Good Health and Well-beingBackground: Leishmania (Viannia) braziliensis is a parasite recognized as the most important etiologic agent of mucosal leishmaniasis (ML) in the New World. In Amazonia, seven different species of Leishmania, etiologic agents of human Cutaneous Leishmaniasis, have been described. Isolated cases of ML have been described for several different species of Leishmania: L. (V.) panamensis, L. (V.) guyanensis and L. (L.) amazonensis. Methodology: Leishmania species were characterized by polymerase chain reaction (PCR) of tissues taken from mucosal biopsies of Amazonian patients who were diagnosed with ML and treated at the Tropical Medicine Foundation of Amazonas (FMTAM) in Manaus, Amazonas state, Brazil. Samples were obtained retrospectively from the pathology laboratory and prospectively from patients attending the aforementioned tertiary care unit. Results: This study reports 46 cases of ML along with their geographical origin, 30 cases caused by L. (V.) braziliensis and 16 cases by L. (V.) guyanensis. This is the first record of ML cases in 16 different municipalities in the state of Amazonas and of simultaneous detection of both species in 4 municipalities of this state. It is also the first record of ML caused by L. (V.) guyanensis in the states of Pará, Acre, and Rondônia and cases of ML caused by L. (V.) braziliensis in the state of Rondônia. Conclusions/Significance: L. (V.) braziliensis is the predominant species that causes ML in the Amazon region. However, contrary to previous studies, L. (V.) guyanensis is also a significant causative agent of ML within the region. The clinical and epidemiological expression of ML in the Manaus region is similar to the rest of the country, although the majority of ML cases are found south of the Amazon River.Instituto de Higiene e Medicina Tropical (IHMT)Centro de Malária e outras Doenças Tropicais (CMDT)RUNde Oliveira Guerra, Jorge AugustoPrestes, Suzane RibeiroSilveira, HenriqueCoelho, Leila Inês de Aguiar Raposo CâmaraGama, PricilaMoura, AristotelesAmato, ValdirBarbosa, Marias das Graças Valede Lima Ferreira, Luiz Carlos2021-05-05T23:25:35Z2011-032011-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/117144eng1935-2727PURE: 26756054https://doi.org/10.1371/journal.pntd.0000980info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:00:11Zoai:run.unl.pt:10362/117144Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:29.860052Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Mucosal leishmaniasis caused by leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon |
title |
Mucosal leishmaniasis caused by leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon |
spellingShingle |
Mucosal leishmaniasis caused by leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon de Oliveira Guerra, Jorge Augusto Infectious Diseases Parasitology Genetics SDG 3 - Good Health and Well-being |
title_short |
Mucosal leishmaniasis caused by leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon |
title_full |
Mucosal leishmaniasis caused by leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon |
title_fullStr |
Mucosal leishmaniasis caused by leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon |
title_full_unstemmed |
Mucosal leishmaniasis caused by leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon |
title_sort |
Mucosal leishmaniasis caused by leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon |
author |
de Oliveira Guerra, Jorge Augusto |
author_facet |
de Oliveira Guerra, Jorge Augusto Prestes, Suzane Ribeiro Silveira, Henrique Coelho, Leila Inês de Aguiar Raposo Câmara Gama, Pricila Moura, Aristoteles Amato, Valdir Barbosa, Marias das Graças Vale de Lima Ferreira, Luiz Carlos |
author_role |
author |
author2 |
Prestes, Suzane Ribeiro Silveira, Henrique Coelho, Leila Inês de Aguiar Raposo Câmara Gama, Pricila Moura, Aristoteles Amato, Valdir Barbosa, Marias das Graças Vale de Lima Ferreira, Luiz Carlos |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Centro de Malária e outras Doenças Tropicais (CMDT) RUN |
dc.contributor.author.fl_str_mv |
de Oliveira Guerra, Jorge Augusto Prestes, Suzane Ribeiro Silveira, Henrique Coelho, Leila Inês de Aguiar Raposo Câmara Gama, Pricila Moura, Aristoteles Amato, Valdir Barbosa, Marias das Graças Vale de Lima Ferreira, Luiz Carlos |
dc.subject.por.fl_str_mv |
Infectious Diseases Parasitology Genetics SDG 3 - Good Health and Well-being |
topic |
Infectious Diseases Parasitology Genetics SDG 3 - Good Health and Well-being |
description |
Background: Leishmania (Viannia) braziliensis is a parasite recognized as the most important etiologic agent of mucosal leishmaniasis (ML) in the New World. In Amazonia, seven different species of Leishmania, etiologic agents of human Cutaneous Leishmaniasis, have been described. Isolated cases of ML have been described for several different species of Leishmania: L. (V.) panamensis, L. (V.) guyanensis and L. (L.) amazonensis. Methodology: Leishmania species were characterized by polymerase chain reaction (PCR) of tissues taken from mucosal biopsies of Amazonian patients who were diagnosed with ML and treated at the Tropical Medicine Foundation of Amazonas (FMTAM) in Manaus, Amazonas state, Brazil. Samples were obtained retrospectively from the pathology laboratory and prospectively from patients attending the aforementioned tertiary care unit. Results: This study reports 46 cases of ML along with their geographical origin, 30 cases caused by L. (V.) braziliensis and 16 cases by L. (V.) guyanensis. This is the first record of ML cases in 16 different municipalities in the state of Amazonas and of simultaneous detection of both species in 4 municipalities of this state. It is also the first record of ML caused by L. (V.) guyanensis in the states of Pará, Acre, and Rondônia and cases of ML caused by L. (V.) braziliensis in the state of Rondônia. Conclusions/Significance: L. (V.) braziliensis is the predominant species that causes ML in the Amazon region. However, contrary to previous studies, L. (V.) guyanensis is also a significant causative agent of ML within the region. The clinical and epidemiological expression of ML in the Manaus region is similar to the rest of the country, although the majority of ML cases are found south of the Amazon River. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-03 2011-03-01T00:00:00Z 2021-05-05T23:25:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/117144 |
url |
http://hdl.handle.net/10362/117144 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1935-2727 PURE: 26756054 https://doi.org/10.1371/journal.pntd.0000980 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799138044583870464 |