Significant increase in azithromycin “resistance” and susceptibility to ceftriaxone and cefixime in Neisseria gonorrhoeae isolates in 26 European countries, 2019
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/8604 |
Resumo: | Euro-GASP network: Claudia Eder, Sonja Pleininger, Steliana Huhlescu, Irith de Baetselier, Blaženka Hunjak, Tatjana Nemeth Blažić, Panagiota Maikanti-Charalampous, Despo Pieridou, Hana Zákoucká, Helena Žemličková, Steen Hoffmann, Susan Cowan, Rita Peetso, Jelena Viktorova, Ndeindo Ndeikoundam, Beatrice Bercot, Anu Patari Sampo, Vesa Kirjavainen, Susanne Buder, Klaus Jansen, Vivi Miriagou, Eszter Balla, Mária Dudás, Guðrún Sigmundsdóttir, Lena Ros Asmundsdottir, Sinead Saab, Brendan Crowley, Anna Carannante, Paola Stefanelli, Gatis Pakarna, Violeta Mavcutko, Robert Cassar, Christopher Barbara, Francesca Vella, Alje Van Dam, Ineke Linde, Dominique Caugant, Hilde Kløvstad, Beata Mlynarczyk-Bonikowska, Maria-José Borrego, Peter Pavlik, Irena Klavs, Tanja Kustec, Julio Vazquez, Asuncion Diaz, Raquel Abad Torreblanca, Inga Velicko, Magnus Unemo, Helen Fifer, Kate Templeton |
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Significant increase in azithromycin “resistance” and susceptibility to ceftriaxone and cefixime in Neisseria gonorrhoeae isolates in 26 European countries, 2019Antimicrobial ResistanceAzithromycinCeftriaxone;EuropeEuropean Economic AreaEuropean Gonococcal Antimicrobial Surveillance Programme (Euro-GASP)European UnionGonorrhoeaSurveillanceTreatmentResistência aos AntimicrobianosInfecções Sexualmente TransmissíveisEuro-GASP network: Claudia Eder, Sonja Pleininger, Steliana Huhlescu, Irith de Baetselier, Blaženka Hunjak, Tatjana Nemeth Blažić, Panagiota Maikanti-Charalampous, Despo Pieridou, Hana Zákoucká, Helena Žemličková, Steen Hoffmann, Susan Cowan, Rita Peetso, Jelena Viktorova, Ndeindo Ndeikoundam, Beatrice Bercot, Anu Patari Sampo, Vesa Kirjavainen, Susanne Buder, Klaus Jansen, Vivi Miriagou, Eszter Balla, Mária Dudás, Guðrún Sigmundsdóttir, Lena Ros Asmundsdottir, Sinead Saab, Brendan Crowley, Anna Carannante, Paola Stefanelli, Gatis Pakarna, Violeta Mavcutko, Robert Cassar, Christopher Barbara, Francesca Vella, Alje Van Dam, Ineke Linde, Dominique Caugant, Hilde Kløvstad, Beata Mlynarczyk-Bonikowska, Maria-José Borrego, Peter Pavlik, Irena Klavs, Tanja Kustec, Julio Vazquez, Asuncion Diaz, Raquel Abad Torreblanca, Inga Velicko, Magnus Unemo, Helen Fifer, Kate TempletonBackground: The European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) performs annual sentinel surveillance of Neisseria gonorrhoeae susceptibility to therapeutically relevant antimicrobials across the European Union/European Economic Area (EU/EEA). We present the Euro-GASP results from 2019 (26 countries), linked to patient epidemiological data, and compared with data from previous years. Methods: Agar dilution and minimum inhibitory concentration (MIC) gradient strip methodologies were used to determine the antimicrobial susceptibility (using EUCAST clinical breakpoints, where available) of 3239 N. gonorrhoeae isolates from 26 countries across the EU/EEA. Significance of differences compared with Euro-GASP results in previous years was analysed using Z-test and the Pearson's χ2 test was used to assess significance of odds ratios for associations between patient epidemiological data and antimicrobial resistance. Results: European N. gonorrhoeae isolates collected between 2016 and 2019 displayed shifting MIC distributions for; ceftriaxone, with highly susceptible isolates increasing over time and occasional resistant isolates each year; cefixime, with highly-susceptible isolates becoming increasingly common; azithromycin, with a shift away from lower MICs towards higher MICs above the EUCAST epidemiological cut-off (ECOFF); and ciprofloxacin which is displaying a similar shift in MICs as observed for azithromycin. In 2019, two isolates displayed ceftriaxone resistance, but both isolates had MICs below the azithromycin ECOFF. Cefixime resistance (0.8%) was associated with patient sex, with resistance higher in females compared with male heterosexuals and men-who-have-sex-with-men (MSM). The number of countries reporting isolates with azithromycin MICs above the ECOFF increased from 76.9% (20/26) in 2016 to 92.3% (24/26) in 2019. Isolates with azithromycin MICs above the ECOFF (9.0%) were associated with pharyngeal infection sites. Following multivariable analysis, ciprofloxacin resistance remained associated with isolates from MSM and heterosexual males compared with females, the absence of a concurrent chlamydial infection, pharyngeal infection sites and patients ≥ 25 years of age. Conclusions: Resistance to ceftriaxone and cefixime remained uncommon in EU/EEA countries in 2019 with a significant decrease in cefixime resistance observed between 2016 and 2019. The significant increase in azithromycin "resistance" (azithromycin MICs above the ECOFF) threatens the effectiveness of the dual therapy (ceftriaxone + azithromycin), i.e., for ceftriaxone-resistant cases, currently recommended in many countries internationally and requires close monitoring.The study was funded by the European Centre for Disease Prevention and Control (Framework Contract No. ECDC/2017/004).BMCRepositório Científico do Instituto Nacional de SaúdeDay, Michaela J.Jacobsson, SusanneSpiteri, GianfrancoKulishev, CarinaSajedi, NoshinWoodford, NeilBlumel, Benjaminvan der Werf, Marieke J.Amato-Gauci, Andrew J.Unemo, MagnusCole, Michelle J.Eder, ClaudiaPleininger, SonjaHuhlescu, Stelianade Baetselier, IrithHunjak, BlaženkaBlažić, Tatjana NemethMaikanti-Charalampous, PanagiotaPieridou, DespoZákoucká, HanaŽemličková, HelenaHoffmann, SteenCowan, SusanPeetso, RitaViktorova, JelenaNdeikoundam, NdeindoBercot, BeatriceSampo, Anu PatariKirjavainen, VesaBuder, SusanneJansen, KlausMiriagou, ViviBalla, EszterDudás, MáriaSigmundsdóttir, GuðrúnAsmundsdottir, Lena RosSaab, SineadCrowley, BrendanCarannante, AnnaStefanelli, PaolaPakarna, GatisMavcutko, VioletaCassar, RobertBarbara, ChristopherVella, FrancescaVan Dam, AljeLinde, InekeCaugant, DominiqueKløvstad, HildeMlynarczyk-Bonikowska, BeataBorrego, Maria-JoséPavlik, PeterKlavs, IrenaKustec, TanjaVazquez, JulioDiaz, AsuncionTorreblanca, Raquel AbadVelicko, IngaUnemo, MagnusFifer, HelenTempleton, Kate2023-03-24T11:50:54Z2022-06-072022-06-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8604engBMC Infect Dis. 2022 Jun 7;22(1):524. doi: 10.1186/s12879-022-07509-w1471-233410.1186/s12879-022-07509-winfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:37Zoai:repositorio.insa.pt:10400.18/8604Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:43:09.790484Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Significant increase in azithromycin “resistance” and susceptibility to ceftriaxone and cefixime in Neisseria gonorrhoeae isolates in 26 European countries, 2019 |
| title |
Significant increase in azithromycin “resistance” and susceptibility to ceftriaxone and cefixime in Neisseria gonorrhoeae isolates in 26 European countries, 2019 |
| spellingShingle |
Significant increase in azithromycin “resistance” and susceptibility to ceftriaxone and cefixime in Neisseria gonorrhoeae isolates in 26 European countries, 2019 Day, Michaela J. Antimicrobial Resistance Azithromycin Ceftriaxone; Europe European Economic Area European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) European Union Gonorrhoea Surveillance Treatment Resistência aos Antimicrobianos Infecções Sexualmente Transmissíveis |
| title_short |
Significant increase in azithromycin “resistance” and susceptibility to ceftriaxone and cefixime in Neisseria gonorrhoeae isolates in 26 European countries, 2019 |
| title_full |
Significant increase in azithromycin “resistance” and susceptibility to ceftriaxone and cefixime in Neisseria gonorrhoeae isolates in 26 European countries, 2019 |
| title_fullStr |
Significant increase in azithromycin “resistance” and susceptibility to ceftriaxone and cefixime in Neisseria gonorrhoeae isolates in 26 European countries, 2019 |
| title_full_unstemmed |
Significant increase in azithromycin “resistance” and susceptibility to ceftriaxone and cefixime in Neisseria gonorrhoeae isolates in 26 European countries, 2019 |
| title_sort |
Significant increase in azithromycin “resistance” and susceptibility to ceftriaxone and cefixime in Neisseria gonorrhoeae isolates in 26 European countries, 2019 |
| author |
Day, Michaela J. |
| author_facet |
Day, Michaela J. Jacobsson, Susanne Spiteri, Gianfranco Kulishev, Carina Sajedi, Noshin Woodford, Neil Blumel, Benjamin van der Werf, Marieke J. Amato-Gauci, Andrew J. Unemo, Magnus Cole, Michelle J. Eder, Claudia Pleininger, Sonja Huhlescu, Steliana de Baetselier, Irith Hunjak, Blaženka Blažić, Tatjana Nemeth Maikanti-Charalampous, Panagiota Pieridou, Despo Zákoucká, Hana Žemličková, Helena Hoffmann, Steen Cowan, Susan Peetso, Rita Viktorova, Jelena Ndeikoundam, Ndeindo Bercot, Beatrice Sampo, Anu Patari Kirjavainen, Vesa Buder, Susanne Jansen, Klaus Miriagou, Vivi Balla, Eszter Dudás, Mária Sigmundsdóttir, Guðrún Asmundsdottir, Lena Ros Saab, Sinead Crowley, Brendan Carannante, Anna Stefanelli, Paola Pakarna, Gatis Mavcutko, Violeta Cassar, Robert Barbara, Christopher Vella, Francesca Van Dam, Alje Linde, Ineke Caugant, Dominique Kløvstad, Hilde Mlynarczyk-Bonikowska, Beata Borrego, Maria-José Pavlik, Peter Klavs, Irena Kustec, Tanja Vazquez, Julio Diaz, Asuncion Torreblanca, Raquel Abad Velicko, Inga Fifer, Helen Templeton, Kate |
| author_role |
author |
| author2 |
Jacobsson, Susanne Spiteri, Gianfranco Kulishev, Carina Sajedi, Noshin Woodford, Neil Blumel, Benjamin van der Werf, Marieke J. Amato-Gauci, Andrew J. Unemo, Magnus Cole, Michelle J. Eder, Claudia Pleininger, Sonja Huhlescu, Steliana de Baetselier, Irith Hunjak, Blaženka Blažić, Tatjana Nemeth Maikanti-Charalampous, Panagiota Pieridou, Despo Zákoucká, Hana Žemličková, Helena Hoffmann, Steen Cowan, Susan Peetso, Rita Viktorova, Jelena Ndeikoundam, Ndeindo Bercot, Beatrice Sampo, Anu Patari Kirjavainen, Vesa Buder, Susanne Jansen, Klaus Miriagou, Vivi Balla, Eszter Dudás, Mária Sigmundsdóttir, Guðrún Asmundsdottir, Lena Ros Saab, Sinead Crowley, Brendan Carannante, Anna Stefanelli, Paola Pakarna, Gatis Mavcutko, Violeta Cassar, Robert Barbara, Christopher Vella, Francesca Van Dam, Alje Linde, Ineke Caugant, Dominique Kløvstad, Hilde Mlynarczyk-Bonikowska, Beata Borrego, Maria-José Pavlik, Peter Klavs, Irena Kustec, Tanja Vazquez, Julio Diaz, Asuncion Torreblanca, Raquel Abad Velicko, Inga Fifer, Helen Templeton, Kate |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Day, Michaela J. Jacobsson, Susanne Spiteri, Gianfranco Kulishev, Carina Sajedi, Noshin Woodford, Neil Blumel, Benjamin van der Werf, Marieke J. Amato-Gauci, Andrew J. Unemo, Magnus Cole, Michelle J. Eder, Claudia Pleininger, Sonja Huhlescu, Steliana de Baetselier, Irith Hunjak, Blaženka Blažić, Tatjana Nemeth Maikanti-Charalampous, Panagiota Pieridou, Despo Zákoucká, Hana Žemličková, Helena Hoffmann, Steen Cowan, Susan Peetso, Rita Viktorova, Jelena Ndeikoundam, Ndeindo Bercot, Beatrice Sampo, Anu Patari Kirjavainen, Vesa Buder, Susanne Jansen, Klaus Miriagou, Vivi Balla, Eszter Dudás, Mária Sigmundsdóttir, Guðrún Asmundsdottir, Lena Ros Saab, Sinead Crowley, Brendan Carannante, Anna Stefanelli, Paola Pakarna, Gatis Mavcutko, Violeta Cassar, Robert Barbara, Christopher Vella, Francesca Van Dam, Alje Linde, Ineke Caugant, Dominique Kløvstad, Hilde Mlynarczyk-Bonikowska, Beata Borrego, Maria-José Pavlik, Peter Klavs, Irena Kustec, Tanja Vazquez, Julio Diaz, Asuncion Torreblanca, Raquel Abad Velicko, Inga Unemo, Magnus Fifer, Helen Templeton, Kate |
| dc.subject.por.fl_str_mv |
Antimicrobial Resistance Azithromycin Ceftriaxone; Europe European Economic Area European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) European Union Gonorrhoea Surveillance Treatment Resistência aos Antimicrobianos Infecções Sexualmente Transmissíveis |
| topic |
Antimicrobial Resistance Azithromycin Ceftriaxone; Europe European Economic Area European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) European Union Gonorrhoea Surveillance Treatment Resistência aos Antimicrobianos Infecções Sexualmente Transmissíveis |
| description |
Euro-GASP network: Claudia Eder, Sonja Pleininger, Steliana Huhlescu, Irith de Baetselier, Blaženka Hunjak, Tatjana Nemeth Blažić, Panagiota Maikanti-Charalampous, Despo Pieridou, Hana Zákoucká, Helena Žemličková, Steen Hoffmann, Susan Cowan, Rita Peetso, Jelena Viktorova, Ndeindo Ndeikoundam, Beatrice Bercot, Anu Patari Sampo, Vesa Kirjavainen, Susanne Buder, Klaus Jansen, Vivi Miriagou, Eszter Balla, Mária Dudás, Guðrún Sigmundsdóttir, Lena Ros Asmundsdottir, Sinead Saab, Brendan Crowley, Anna Carannante, Paola Stefanelli, Gatis Pakarna, Violeta Mavcutko, Robert Cassar, Christopher Barbara, Francesca Vella, Alje Van Dam, Ineke Linde, Dominique Caugant, Hilde Kløvstad, Beata Mlynarczyk-Bonikowska, Maria-José Borrego, Peter Pavlik, Irena Klavs, Tanja Kustec, Julio Vazquez, Asuncion Diaz, Raquel Abad Torreblanca, Inga Velicko, Magnus Unemo, Helen Fifer, Kate Templeton |
| publishDate |
2022 |
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2022-06-07 2022-06-07T00:00:00Z 2023-03-24T11:50:54Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/10400.18/8604 |
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http://hdl.handle.net/10400.18/8604 |
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eng |
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eng |
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BMC Infect Dis. 2022 Jun 7;22(1):524. doi: 10.1186/s12879-022-07509-w 1471-2334 10.1186/s12879-022-07509-w |
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