Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomolecules
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/34418 |
Resumo: | A plethora of applications using polysaccharides have been developed in recent years due to their availability as well as their frequent nontoxicity and biodegradability. These polymers are usually obtained from renewable sources or are byproducts of industrial processes, thus, their use is collaborative in waste management and shows promise for an enhanced sustainable circular economy. Regarding the development of novel delivery systems for biotherapeutics, the potential of polysaccharides is attractive for the previously mentioned properties and also for the possibility of chemical modification of their structures, their ability to form matrixes of diverse architectures and mechanical properties, as well as for their ability to maintain bioactivity following incorporation of the biomolecules into the matrix. Biotherapeutics, such as proteins, growth factors, gene vectors, enzymes, hormones, DNA/RNA, and antibodies are currently in use as major therapeutics in a wide range of pathologies. In the present review, we summarize recent progress in the development of polysaccharide-based hydrogels of diverse nature, alone or in combination with other polymers or drug delivery systems, which have been implemented in the delivery of biotherapeutics in the pharmaceutical and biomedical fields. |
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Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomoleculesBiotherapeuticsHydrogelsControlled deliveryPolysaccharidesTissue engineeringStimuli-responsivenessA plethora of applications using polysaccharides have been developed in recent years due to their availability as well as their frequent nontoxicity and biodegradability. These polymers are usually obtained from renewable sources or are byproducts of industrial processes, thus, their use is collaborative in waste management and shows promise for an enhanced sustainable circular economy. Regarding the development of novel delivery systems for biotherapeutics, the potential of polysaccharides is attractive for the previously mentioned properties and also for the possibility of chemical modification of their structures, their ability to form matrixes of diverse architectures and mechanical properties, as well as for their ability to maintain bioactivity following incorporation of the biomolecules into the matrix. Biotherapeutics, such as proteins, growth factors, gene vectors, enzymes, hormones, DNA/RNA, and antibodies are currently in use as major therapeutics in a wide range of pathologies. In the present review, we summarize recent progress in the development of polysaccharide-based hydrogels of diverse nature, alone or in combination with other polymers or drug delivery systems, which have been implemented in the delivery of biotherapeutics in the pharmaceutical and biomedical fields.American Chemical Society2022-09-13T00:00:00Z2021-09-13T00:00:00Z2021-09-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/34418eng10.1021/acsbiomaterials.0c01784Rial-Hermida, M. IsabelRey-Rico, AnaBlanco-Fernandez, BarbaraCarballo-Pedrares, NataliaByrne, Eimear M.Mano, João F.info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:06:28Zoai:ria.ua.pt:10773/34418Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:05:45.226077Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomolecules |
title |
Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomolecules |
spellingShingle |
Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomolecules Rial-Hermida, M. Isabel Biotherapeutics Hydrogels Controlled delivery Polysaccharides Tissue engineering Stimuli-responsiveness |
title_short |
Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomolecules |
title_full |
Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomolecules |
title_fullStr |
Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomolecules |
title_full_unstemmed |
Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomolecules |
title_sort |
Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomolecules |
author |
Rial-Hermida, M. Isabel |
author_facet |
Rial-Hermida, M. Isabel Rey-Rico, Ana Blanco-Fernandez, Barbara Carballo-Pedrares, Natalia Byrne, Eimear M. Mano, João F. |
author_role |
author |
author2 |
Rey-Rico, Ana Blanco-Fernandez, Barbara Carballo-Pedrares, Natalia Byrne, Eimear M. Mano, João F. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Rial-Hermida, M. Isabel Rey-Rico, Ana Blanco-Fernandez, Barbara Carballo-Pedrares, Natalia Byrne, Eimear M. Mano, João F. |
dc.subject.por.fl_str_mv |
Biotherapeutics Hydrogels Controlled delivery Polysaccharides Tissue engineering Stimuli-responsiveness |
topic |
Biotherapeutics Hydrogels Controlled delivery Polysaccharides Tissue engineering Stimuli-responsiveness |
description |
A plethora of applications using polysaccharides have been developed in recent years due to their availability as well as their frequent nontoxicity and biodegradability. These polymers are usually obtained from renewable sources or are byproducts of industrial processes, thus, their use is collaborative in waste management and shows promise for an enhanced sustainable circular economy. Regarding the development of novel delivery systems for biotherapeutics, the potential of polysaccharides is attractive for the previously mentioned properties and also for the possibility of chemical modification of their structures, their ability to form matrixes of diverse architectures and mechanical properties, as well as for their ability to maintain bioactivity following incorporation of the biomolecules into the matrix. Biotherapeutics, such as proteins, growth factors, gene vectors, enzymes, hormones, DNA/RNA, and antibodies are currently in use as major therapeutics in a wide range of pathologies. In the present review, we summarize recent progress in the development of polysaccharide-based hydrogels of diverse nature, alone or in combination with other polymers or drug delivery systems, which have been implemented in the delivery of biotherapeutics in the pharmaceutical and biomedical fields. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-13T00:00:00Z 2021-09-13 2022-09-13T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/34418 |
url |
http://hdl.handle.net/10773/34418 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1021/acsbiomaterials.0c01784 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137712560668672 |