Fatal case of progressive Mpox in a patient with AIDS: viral enteropathy and malabsorption demanding the use of full parenteral ARV and endovenous Cidofovir

Detalhes bibliográficos
Autor(a) principal: Caria, João
Data de Publicação: 2023
Outros Autores: Vara-Luiz, Francisco, Maia, Inês, Joosten, Anneke, Val-Flores, Luís, Pinheiro, Hélder, Póvoas, Diana, Germano, Nuno, Maltez, Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/56863
Resumo: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Fatal case of progressive Mpox in a patient with AIDS: viral enteropathy and malabsorption demanding the use of full parenteral ARV and endovenous CidofovirAIDSHIVCidofovirEnteropathyFatalMpoxProgressiveTecovirimat© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).We report a fatal case of disseminated mpox infection that progressed over more than three months in an HIV-infected patient with acquired immunodeficiency syndrome (AIDS). Mucocutaneous, pleuropulmonary, central nervous system, and gastrointestinal involvement was documented. This course of disease resembles progressive vaccinia, a formerly reported disease caused by uncontrolled replication of smallpox vaccination orthopoxviruses in immunosuppressed patients. Severe small bowel involvement jeopardized normal oral tecovirimat and antiretroviral therapy absorption. This problem prompted the use of full parenteral antiretrovirals and endovenous cidofovir. Although a remarkable decrease in HIV viral load occurred in six days, mpox infection continued to progress, and the patient died of septic shock. This case offers new clinical insights on the presentation of severe disease in AIDS patients. Moreover, this case alerts for the need for prompt therapy initiation in patients at risk of ominous clinical progression.The writing of this manuscript received the support of Fundação para a Ciência e a Tecnologia, grant number UIDB/04295/2020 and UIDP/04295/2020.MDPIRepositório da Universidade de LisboaCaria, JoãoVara-Luiz, FranciscoMaia, InêsJoosten, AnnekeVal-Flores, LuísPinheiro, HélderPóvoas, DianaGermano, NunoMaltez, Fernando2023-03-28T13:22:04Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56863engInfect Dis Rep. 2023 Mar 16;15(2):171-1792036-743010.3390/idr150200182036-7449info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:04:49Zoai:repositorio.ul.pt:10451/56863Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:22.968063Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Fatal case of progressive Mpox in a patient with AIDS: viral enteropathy and malabsorption demanding the use of full parenteral ARV and endovenous Cidofovir
title Fatal case of progressive Mpox in a patient with AIDS: viral enteropathy and malabsorption demanding the use of full parenteral ARV and endovenous Cidofovir
spellingShingle Fatal case of progressive Mpox in a patient with AIDS: viral enteropathy and malabsorption demanding the use of full parenteral ARV and endovenous Cidofovir
Caria, João
AIDS
HIV
Cidofovir
Enteropathy
Fatal
Mpox
Progressive
Tecovirimat
title_short Fatal case of progressive Mpox in a patient with AIDS: viral enteropathy and malabsorption demanding the use of full parenteral ARV and endovenous Cidofovir
title_full Fatal case of progressive Mpox in a patient with AIDS: viral enteropathy and malabsorption demanding the use of full parenteral ARV and endovenous Cidofovir
title_fullStr Fatal case of progressive Mpox in a patient with AIDS: viral enteropathy and malabsorption demanding the use of full parenteral ARV and endovenous Cidofovir
title_full_unstemmed Fatal case of progressive Mpox in a patient with AIDS: viral enteropathy and malabsorption demanding the use of full parenteral ARV and endovenous Cidofovir
title_sort Fatal case of progressive Mpox in a patient with AIDS: viral enteropathy and malabsorption demanding the use of full parenteral ARV and endovenous Cidofovir
author Caria, João
author_facet Caria, João
Vara-Luiz, Francisco
Maia, Inês
Joosten, Anneke
Val-Flores, Luís
Pinheiro, Hélder
Póvoas, Diana
Germano, Nuno
Maltez, Fernando
author_role author
author2 Vara-Luiz, Francisco
Maia, Inês
Joosten, Anneke
Val-Flores, Luís
Pinheiro, Hélder
Póvoas, Diana
Germano, Nuno
Maltez, Fernando
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Caria, João
Vara-Luiz, Francisco
Maia, Inês
Joosten, Anneke
Val-Flores, Luís
Pinheiro, Hélder
Póvoas, Diana
Germano, Nuno
Maltez, Fernando
dc.subject.por.fl_str_mv AIDS
HIV
Cidofovir
Enteropathy
Fatal
Mpox
Progressive
Tecovirimat
topic AIDS
HIV
Cidofovir
Enteropathy
Fatal
Mpox
Progressive
Tecovirimat
description © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2023
dc.date.none.fl_str_mv 2023-03-28T13:22:04Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/56863
url http://hdl.handle.net/10451/56863
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Infect Dis Rep. 2023 Mar 16;15(2):171-179
2036-7430
10.3390/idr15020018
2036-7449
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eu_rights_str_mv openAccess
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publisher.none.fl_str_mv MDPI
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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