The rigid amphipathic fusion Inhibitor dUY11 acts through photosensitization of viruses

Detalhes bibliográficos
Autor(a) principal: Vigant, Frederic
Data de Publicação: 2014
Outros Autores: Hollmann, Axel, Lee, Jihye, Santos, Nuno C., Jung, Michael E., Lee, Benhur
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/23601
Resumo: Copyright © 2014, American Society for Microbiology. All Rights Reserved.
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spelling The rigid amphipathic fusion Inhibitor dUY11 acts through photosensitization of virusesCopyright © 2014, American Society for Microbiology. All Rights Reserved.Supplemental material for this article may be found at http://dx.doi.org/10.1128 /JVI.02907-13.Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensitizers: their antiviral effect is dependent on light and the generation of singlet oxygen (1O2), similar to the mechanistic paradigm established for LJ001, a chemically unrelated class of Broad-SAVE. Photosensitization of viral membranes is a common mechanism that underlies these Broad-SAVE.This work was supported by NIH grants U01 AI070495, U01 AI082100, R01 AI069317, and U54 AI065359 (PSWRCE) (to B.L.) and by Fundação para a Ciência e a Tecnologia-Ministério da Educação e Ciência (Portugal) project DELIN-HIVERA/0002/2013 and fellowship SFRH/BPD/72037/2010 (to N.C.S. and A.H., respectively)American Society for MicrobiologyRepositório da Universidade de LisboaVigant, FredericHollmann, AxelLee, JihyeSantos, Nuno C.Jung, Michael E.Lee, Benhur2016-05-04T15:11:15Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/23601engJournal of Virology, February 2014, Volume 88, Number 3, p. 1849–18531098-551410.1128/JVI.02907-13info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:11:43Zoai:repositorio.ul.pt:10451/23601Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:40:55.182151Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The rigid amphipathic fusion Inhibitor dUY11 acts through photosensitization of viruses
title The rigid amphipathic fusion Inhibitor dUY11 acts through photosensitization of viruses
spellingShingle The rigid amphipathic fusion Inhibitor dUY11 acts through photosensitization of viruses
Vigant, Frederic
title_short The rigid amphipathic fusion Inhibitor dUY11 acts through photosensitization of viruses
title_full The rigid amphipathic fusion Inhibitor dUY11 acts through photosensitization of viruses
title_fullStr The rigid amphipathic fusion Inhibitor dUY11 acts through photosensitization of viruses
title_full_unstemmed The rigid amphipathic fusion Inhibitor dUY11 acts through photosensitization of viruses
title_sort The rigid amphipathic fusion Inhibitor dUY11 acts through photosensitization of viruses
author Vigant, Frederic
author_facet Vigant, Frederic
Hollmann, Axel
Lee, Jihye
Santos, Nuno C.
Jung, Michael E.
Lee, Benhur
author_role author
author2 Hollmann, Axel
Lee, Jihye
Santos, Nuno C.
Jung, Michael E.
Lee, Benhur
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Vigant, Frederic
Hollmann, Axel
Lee, Jihye
Santos, Nuno C.
Jung, Michael E.
Lee, Benhur
description Copyright © 2014, American Society for Microbiology. All Rights Reserved.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
2016-05-04T15:11:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/23601
url http://hdl.handle.net/10451/23601
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Virology, February 2014, Volume 88, Number 3, p. 1849–1853
1098-5514
10.1128/JVI.02907-13
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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