Assessment of prognostic performance of Albumin-Bilirubin, Child-Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleeding

Detalhes bibliográficos
Autor(a) principal: Xavier, Sofia A.
Data de Publicação: 2018
Outros Autores: Vilas-Boas, Ricardo, Boal Carvalho, Pedro, Magalhães, Joana T., Marinho, Carla M., Cotter, José Almeida Berkeley
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/58301
Resumo: The Albumin-Bilirubin (ALBI) score was developed recently to assess the severity of liver dysfunction. We aimed to assess its prognostic performance in patients with liver cirrhosis complicated with upper gastrointestinal bleeding (UGIB) while comparing it with Child-Pugh (CP) and Model for End-stage Liver Disease (MELD) scores.
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spelling Assessment of prognostic performance of Albumin-Bilirubin, Child-Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleedingAdultAgedAged, 80 and overArea Under CurveBilirubinBiomarkersCreatinineEsophageal and Gastric VaricesFemaleGastrointestinal HemorrhageHospital MortalityHumansLiver CirrhosisMaleMiddle AgedPatient AdmissionPortugalPredictive Value of TestsPrognosisProthrombin TimeROC CurveReproducibility of ResultsRetrospective StudiesRisk FactorsSerum Albumin, HumanSeverity of Illness IndexTime FactorsDecision Support TechniquesModels, Biologicalcirrhosisprognostic scoresupper gastrointestinal bleedingCiências Médicas::Medicina BásicaScience & TechnologyThe Albumin-Bilirubin (ALBI) score was developed recently to assess the severity of liver dysfunction. We aimed to assess its prognostic performance in patients with liver cirrhosis complicated with upper gastrointestinal bleeding (UGIB) while comparing it with Child-Pugh (CP) and Model for End-stage Liver Disease (MELD) scores.Objective The Albumin–Bilirubin (ALBI) score was developed recently to assess the severity of liver dysfunction. We aimed to assess its prognostic performance in patients with liver cirrhosis complicated with upper gastrointestinal bleeding (UGIB) while comparing it with Child–Pugh (CP) and Model for End-stage Liver Disease (MELD) scores. Patients and methods This was a retrospective unicentric study, including consecutive adult patients with cirrhosis admitted for UGIB between January 2011 and November 2015. Clinical, analytical, and endoscopic variables were assessed and ALBI, CP, and MELD scores at admission were calculated. Results This study included 111 patients. During the first 30 days of follow-up, 12 (10.8%) patients died, and during the first year of follow-up, another 10 patients died (first-year mortality of 19.8%). On comparing the three scores, for in-stay and 30-day mortality, only the ALBI score showed statistically significant results, with an area under the curve (AUC) of 0.80 (P<0.01) for both outcomes. For first-year mortality, AUC for ALBI, CP, and MELD scores were 0.71 (P<0.01), 0.64 (P<0.05), and 0.66 (P=0.02), respectively, whereas for global mortality, AUC were 0.75 (P<0.01), 0.72 (P<0.01), and 0.72 (P<0.01), respectively. On comparing the AUC of the three scores, no significant differences were found in first-year mortality and global mortality. Conclusion In our series, the ALBI score accurately predicted both in-stay and 30-day mortality, whereas CP and MELD scores could not predict these outcomes. All scores showed a fair prognostic prediction performance for first-year and global mortality. These results suggest that the ALBI score is particularly useful in the assessment of short-term outcomes, with a better performance than the most commonly used scores.info:eu-repo/semantics/publishedVersionWolters Kluwer HealthUniversidade do MinhoXavier, Sofia A.Vilas-Boas, RicardoBoal Carvalho, PedroMagalhães, Joana T.Marinho, Carla M.Cotter, José Almeida Berkeley2018-062018-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58301engXavier, S. A., Vilas-Boas, R., Boal Carvalho, P., Magalhães, J. T., Marinho, C. M., & Cotter, J. B. (2018). Assessment of prognostic performance of Albumin–Bilirubin, Child–Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleeding. European journal of gastroenterology & hepatology, 30(6), 652-6580954-691X1473-568710.1097/MEG.000000000000108729438135https://journals.lww.com/eurojgh/Abstract/2018/06000/Assessment_of_prognostic_performance_of.10.aspxinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:15:19Zoai:repositorium.sdum.uminho.pt:1822/58301Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:07:43.716462Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Assessment of prognostic performance of Albumin-Bilirubin, Child-Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleeding
title Assessment of prognostic performance of Albumin-Bilirubin, Child-Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleeding
spellingShingle Assessment of prognostic performance of Albumin-Bilirubin, Child-Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleeding
Xavier, Sofia A.
Adult
Aged
Aged, 80 and over
Area Under Curve
Bilirubin
Biomarkers
Creatinine
Esophageal and Gastric Varices
Female
Gastrointestinal Hemorrhage
Hospital Mortality
Humans
Liver Cirrhosis
Male
Middle Aged
Patient Admission
Portugal
Predictive Value of Tests
Prognosis
Prothrombin Time
ROC Curve
Reproducibility of Results
Retrospective Studies
Risk Factors
Serum Albumin, Human
Severity of Illness Index
Time Factors
Decision Support Techniques
Models, Biological
cirrhosis
prognostic scores
upper gastrointestinal bleeding
Ciências Médicas::Medicina Básica
Science & Technology
title_short Assessment of prognostic performance of Albumin-Bilirubin, Child-Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleeding
title_full Assessment of prognostic performance of Albumin-Bilirubin, Child-Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleeding
title_fullStr Assessment of prognostic performance of Albumin-Bilirubin, Child-Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleeding
title_full_unstemmed Assessment of prognostic performance of Albumin-Bilirubin, Child-Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleeding
title_sort Assessment of prognostic performance of Albumin-Bilirubin, Child-Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleeding
author Xavier, Sofia A.
author_facet Xavier, Sofia A.
Vilas-Boas, Ricardo
Boal Carvalho, Pedro
Magalhães, Joana T.
Marinho, Carla M.
Cotter, José Almeida Berkeley
author_role author
author2 Vilas-Boas, Ricardo
Boal Carvalho, Pedro
Magalhães, Joana T.
Marinho, Carla M.
Cotter, José Almeida Berkeley
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Xavier, Sofia A.
Vilas-Boas, Ricardo
Boal Carvalho, Pedro
Magalhães, Joana T.
Marinho, Carla M.
Cotter, José Almeida Berkeley
dc.subject.por.fl_str_mv Adult
Aged
Aged, 80 and over
Area Under Curve
Bilirubin
Biomarkers
Creatinine
Esophageal and Gastric Varices
Female
Gastrointestinal Hemorrhage
Hospital Mortality
Humans
Liver Cirrhosis
Male
Middle Aged
Patient Admission
Portugal
Predictive Value of Tests
Prognosis
Prothrombin Time
ROC Curve
Reproducibility of Results
Retrospective Studies
Risk Factors
Serum Albumin, Human
Severity of Illness Index
Time Factors
Decision Support Techniques
Models, Biological
cirrhosis
prognostic scores
upper gastrointestinal bleeding
Ciências Médicas::Medicina Básica
Science & Technology
topic Adult
Aged
Aged, 80 and over
Area Under Curve
Bilirubin
Biomarkers
Creatinine
Esophageal and Gastric Varices
Female
Gastrointestinal Hemorrhage
Hospital Mortality
Humans
Liver Cirrhosis
Male
Middle Aged
Patient Admission
Portugal
Predictive Value of Tests
Prognosis
Prothrombin Time
ROC Curve
Reproducibility of Results
Retrospective Studies
Risk Factors
Serum Albumin, Human
Severity of Illness Index
Time Factors
Decision Support Techniques
Models, Biological
cirrhosis
prognostic scores
upper gastrointestinal bleeding
Ciências Médicas::Medicina Básica
Science & Technology
description The Albumin-Bilirubin (ALBI) score was developed recently to assess the severity of liver dysfunction. We aimed to assess its prognostic performance in patients with liver cirrhosis complicated with upper gastrointestinal bleeding (UGIB) while comparing it with Child-Pugh (CP) and Model for End-stage Liver Disease (MELD) scores.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
2018-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/58301
url http://hdl.handle.net/1822/58301
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Xavier, S. A., Vilas-Boas, R., Boal Carvalho, P., Magalhães, J. T., Marinho, C. M., & Cotter, J. B. (2018). Assessment of prognostic performance of Albumin–Bilirubin, Child–Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleeding. European journal of gastroenterology & hepatology, 30(6), 652-658
0954-691X
1473-5687
10.1097/MEG.0000000000001087
29438135
https://journals.lww.com/eurojgh/Abstract/2018/06000/Assessment_of_prognostic_performance_of.10.aspx
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer Health
publisher.none.fl_str_mv Wolters Kluwer Health
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132497243537408

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