SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Detalhes bibliográficos
Autor(a) principal: Portuguese network for SARS-CoV-2 genomics (Consortium)
Data de Publicação: 2022
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/150097
Resumo: © The Author(s) 2022.
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spelling SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal© The Author(s) 2022.BACKGROUND: Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. METHODS: By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARS-CoV-2 introductions and early dissemination in Portugal. RESULTS: We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. CONCLUSIONS: Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNPortuguese network for SARS-CoV-2 genomics (Consortium)2023-03-06T22:23:18Z2022-01-282022-01-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/150097eng2730-664xPURE: 54910773https://doi.org/10.1038/s43856-022-00072-0info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:31:56Zoai:run.unl.pt:10362/150097Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:57.145019Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal
title SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal
spellingShingle SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal
Portuguese network for SARS-CoV-2 genomics (Consortium)
title_short SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal
title_full SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal
title_fullStr SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal
title_full_unstemmed SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal
title_sort SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal
author Portuguese network for SARS-CoV-2 genomics (Consortium)
author_facet Portuguese network for SARS-CoV-2 genomics (Consortium)
author_role author
dc.contributor.none.fl_str_mv Centre for Toxicogenomics and Human Health (ToxOmics)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Portuguese network for SARS-CoV-2 genomics (Consortium)
description © The Author(s) 2022.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-28
2022-01-28T00:00:00Z
2023-03-06T22:23:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/150097
url http://hdl.handle.net/10362/150097
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2730-664x
PURE: 54910773
https://doi.org/10.1038/s43856-022-00072-0
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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