Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/107309 https://doi.org/10.3390/polym11040653 |
Resumo: | Recently, the biomedical scientists who are working in the skin regeneration area have proposed asymmetric membranes as ideal wound dressings, since they are able to reproduce both layers of skin and improve the healing process as well as make it less painful. Herein, an electrospinning technique was used to produce new asymmetric membranes. The protective layer was composed of a blending solution between polycaprolactone and polylactic acid, whereas the underlying layer was comprised of methacrylated gelatin and chitosan. The chemical/physical properties, the in vitro hemo- and biocompatibility of the nanofibrous membranes were evaluated. The results obtained reveal that the produced membranes exhibited a wettability able to provide a moist environment at wound site. Moreover, the membranes' hemocompatibility and fibroblast cell adhesion, spreading and proliferation at the surface of the membranes were also noticed in the in vitro assays. Such results highlight the suitability of these asymmetric membranes for wound dressing applications. |
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spelling |
Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressingelectrospinningasymmetric membraneskin regenerationbiocompatibilityRecently, the biomedical scientists who are working in the skin regeneration area have proposed asymmetric membranes as ideal wound dressings, since they are able to reproduce both layers of skin and improve the healing process as well as make it less painful. Herein, an electrospinning technique was used to produce new asymmetric membranes. The protective layer was composed of a blending solution between polycaprolactone and polylactic acid, whereas the underlying layer was comprised of methacrylated gelatin and chitosan. The chemical/physical properties, the in vitro hemo- and biocompatibility of the nanofibrous membranes were evaluated. The results obtained reveal that the produced membranes exhibited a wettability able to provide a moist environment at wound site. Moreover, the membranes' hemocompatibility and fibroblast cell adhesion, spreading and proliferation at the surface of the membranes were also noticed in the in vitro assays. Such results highlight the suitability of these asymmetric membranes for wound dressing applications.MDPI2019-04-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107309http://hdl.handle.net/10316/107309https://doi.org/10.3390/polym11040653eng2073-4360Alves, PatríciaSantos, MartaMendes, SabrinaMiguel, Sónia P.Sá, Kevin D. deCabral, Cátia S. D.Correia, Ilídio J.Ferreira, Paulainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-03T09:12:07Zoai:estudogeral.uc.pt:10316/107309Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:40.869363Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing |
title |
Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing |
spellingShingle |
Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing Alves, Patrícia electrospinning asymmetric membrane skin regeneration biocompatibility |
title_short |
Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing |
title_full |
Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing |
title_fullStr |
Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing |
title_full_unstemmed |
Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing |
title_sort |
Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing |
author |
Alves, Patrícia |
author_facet |
Alves, Patrícia Santos, Marta Mendes, Sabrina Miguel, Sónia P. Sá, Kevin D. de Cabral, Cátia S. D. Correia, Ilídio J. Ferreira, Paula |
author_role |
author |
author2 |
Santos, Marta Mendes, Sabrina Miguel, Sónia P. Sá, Kevin D. de Cabral, Cátia S. D. Correia, Ilídio J. Ferreira, Paula |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Alves, Patrícia Santos, Marta Mendes, Sabrina Miguel, Sónia P. Sá, Kevin D. de Cabral, Cátia S. D. Correia, Ilídio J. Ferreira, Paula |
dc.subject.por.fl_str_mv |
electrospinning asymmetric membrane skin regeneration biocompatibility |
topic |
electrospinning asymmetric membrane skin regeneration biocompatibility |
description |
Recently, the biomedical scientists who are working in the skin regeneration area have proposed asymmetric membranes as ideal wound dressings, since they are able to reproduce both layers of skin and improve the healing process as well as make it less painful. Herein, an electrospinning technique was used to produce new asymmetric membranes. The protective layer was composed of a blending solution between polycaprolactone and polylactic acid, whereas the underlying layer was comprised of methacrylated gelatin and chitosan. The chemical/physical properties, the in vitro hemo- and biocompatibility of the nanofibrous membranes were evaluated. The results obtained reveal that the produced membranes exhibited a wettability able to provide a moist environment at wound site. Moreover, the membranes' hemocompatibility and fibroblast cell adhesion, spreading and proliferation at the surface of the membranes were also noticed in the in vitro assays. Such results highlight the suitability of these asymmetric membranes for wound dressing applications. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-04-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/107309 http://hdl.handle.net/10316/107309 https://doi.org/10.3390/polym11040653 |
url |
http://hdl.handle.net/10316/107309 https://doi.org/10.3390/polym11040653 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2073-4360 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134123064819712 |