Infective endocarditis risk in patients with bicuspid aortic valve: systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Couto Pereira, Sara Cristina
Data de Publicação: 2023
Outros Autores: Abrantes, Ana, António, Pedro Silverio, Morais, Pedro, Santos De Sousa, Catarina Isabel, David, Cláudio, Pinto, Fausto J., Almeida, Ana G., Caldeira, Daniel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/59264
Resumo: © 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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spelling Infective endocarditis risk in patients with bicuspid aortic valve: systematic review and meta-analysisAntibiotic prophylaxisBicuspid aortic valveInfective endocarditis© 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)Background: Antibiotic prophylaxis in bicuspid aortic valve patients is currently a matter of debate. Although it is no longer recommended by international guidelines, some studies indicate a high risk of infective endocarditis. We aim to evaluate the risk of native valve infective endocarditis in bicuspid aortic valve patients and compare to individuals with tricuspid aortic valve. Methods: Study search of longitudinal studies regarding infective endocarditis incidence in bicuspid aortic valve patients (compared with tricuspid aortic valve/overall population) was conducted through OVID in the following electronic databases: MEDLINE, CENTRAL, EMBASE; from inception until October 2020. The outcomes of interest were the incidence rate and relative risk of infective endocarditis. The relative risk and incidence rate (number of cases for each 10 000 persons-year) with their 95 % confidence intervals (95 %CI) were estimated using a random effects model meta-analysis. The study protocol was registered at PROSPERO CRD42020218639. Results: Eight cohort studies were selected, with a total of 5351 bicuspid aortic valve patients. During follow up, 184 bicuspid aortic valve patients presented infective endocarditis, with an incidence rate of 48.13 per 10,000 patients-year (95 %CI 22.24-74.02), and a 12-fold (RR: 12.03, 95 %CI 5.45-26.54) increased risk compared with general population, after adjusted estimates. Conclusions: This systematic review and meta-analysis suggests that bicuspid aortic valve patients have a significant high risk of native valve infective endocarditis. Large prospective high-quality studies are required to estimate more accurately the incidence of infective endocarditis, the relative risk and the potential benefit of antibiotic prophylaxis.This work was supported by national funds, Fundação para a Ciência e a Tecnologia (Portugal), reference number UIDB/00306/2020.ElsevierRepositório da Universidade de LisboaCouto Pereira, Sara CristinaAbrantes, AnaAntónio, Pedro SilverioMorais, PedroSantos De Sousa, Catarina IsabelDavid, CláudioPinto, Fausto J.Almeida, Ana G.Caldeira, Daniel2023-09-13T13:43:21Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/59264engIJC Heart & Vasculature 47 (2023) 10124910.1016/j.ijcha.2023.1012492352-9067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:08:17Zoai:repositorio.ul.pt:10451/59264Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:09:12.117241Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Infective endocarditis risk in patients with bicuspid aortic valve: systematic review and meta-analysis
title Infective endocarditis risk in patients with bicuspid aortic valve: systematic review and meta-analysis
spellingShingle Infective endocarditis risk in patients with bicuspid aortic valve: systematic review and meta-analysis
Couto Pereira, Sara Cristina
Antibiotic prophylaxis
Bicuspid aortic valve
Infective endocarditis
title_short Infective endocarditis risk in patients with bicuspid aortic valve: systematic review and meta-analysis
title_full Infective endocarditis risk in patients with bicuspid aortic valve: systematic review and meta-analysis
title_fullStr Infective endocarditis risk in patients with bicuspid aortic valve: systematic review and meta-analysis
title_full_unstemmed Infective endocarditis risk in patients with bicuspid aortic valve: systematic review and meta-analysis
title_sort Infective endocarditis risk in patients with bicuspid aortic valve: systematic review and meta-analysis
author Couto Pereira, Sara Cristina
author_facet Couto Pereira, Sara Cristina
Abrantes, Ana
António, Pedro Silverio
Morais, Pedro
Santos De Sousa, Catarina Isabel
David, Cláudio
Pinto, Fausto J.
Almeida, Ana G.
Caldeira, Daniel
author_role author
author2 Abrantes, Ana
António, Pedro Silverio
Morais, Pedro
Santos De Sousa, Catarina Isabel
David, Cláudio
Pinto, Fausto J.
Almeida, Ana G.
Caldeira, Daniel
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Couto Pereira, Sara Cristina
Abrantes, Ana
António, Pedro Silverio
Morais, Pedro
Santos De Sousa, Catarina Isabel
David, Cláudio
Pinto, Fausto J.
Almeida, Ana G.
Caldeira, Daniel
dc.subject.por.fl_str_mv Antibiotic prophylaxis
Bicuspid aortic valve
Infective endocarditis
topic Antibiotic prophylaxis
Bicuspid aortic valve
Infective endocarditis
description © 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
publishDate 2023
dc.date.none.fl_str_mv 2023-09-13T13:43:21Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/59264
url http://hdl.handle.net/10451/59264
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv IJC Heart & Vasculature 47 (2023) 101249
10.1016/j.ijcha.2023.101249
2352-9067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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