Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021)
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/8313 |
Resumo: | This article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention? |
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Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021)AcrylamideGlycidamideExposure LevelTime-trendHBM4EUHBM4EU Aligned StudiesAcrilamidaCaracterização da ExposiçãoVariação TemporalDeterminantes da Saúde e da DoençaThis article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention?Acrylamide, a substance potentially carcinogenic in humans, represents a very prevalent contaminant in food and is also contained in tobacco smoke. Occupational exposure to higher concentrations of acrylamide was shown to induce neurotoxicity in humans. To minimize related risks for public health, it is vital to obtain data on the actual level of exposure in differently affected segments of the population. To achieve this aim, acrylamide has been added to the list of substances of concern to be investigated in the HBM4EU project, a European initiative to obtain biomonitoring data for a number of pollutants highly relevant for public health. This report summarizes the results obtained for acrylamide, with a focus on time-trends and recent exposure levels, obtained by HBM4EU as well as by associated studies in a total of seven European countries. Mean biomarker levels were compared by sampling year and time-trends were analyzed using linear regression models and an adequate statistical test. An increasing trend of acrylamide biomarker concentrations was found in children for the years 2014–2017, while in adults an overall increase in exposure was found to be not significant for the time period of observation (2000–2021). For smokers, represented by two studies and sampling for, over a total three years, no clear tendency was observed. In conclusion, samples from European countries indicate that average acrylamide exposure still exceeds suggested benchmark levels and may be of specific concern in children. More research is required to confirm trends of declining values observed in most recent years.This work received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations. The Norwegian Institute of Public Health (NIPH) contributed to the funding of the Norwegian Environmental Biobank (NEB). The laboratory measurements were partly funded by the Research Council of Norway through research projects (275903 and 268465).MDPIRepositório Científico do Instituto Nacional de SaúdePoteser, MichaelLaguzzi, FedericaSchettgen, ThomasVogel, NinaWeber, TillMurawski, AlineSchmidt, PhillippRüther, MariaKolossa-Gehring, MarikeNamorado, SóniaVan Nieuwenhuyse, AnAppenzeller, BriceDufthaksdóttir, EddaOlafsdottir, KristinHaug, Line SmåstuenThomsen, CathrineBarbone, FabioRosolen, ValentinaRAMBAUD, LoicRIOU, MargauxGöen, ThomasNübler, StefanieSchäfer, MoritzZarrabi, Karin H.A.Gilles, LieseRodriguez Martin, LauraSchoeters, GretaSepai, OvnairGovarts, EvaMoshammer, Hanns2022-11-15T12:42:28Z2022-08-022022-08-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8313engToxics. 2022 Aug 2;10(8):443. doi: 10.3390/toxics100804432305-630410.3390/toxics10080443info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:29Zoai:repositorio.insa.pt:10400.18/8313Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:56.658862Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021) |
| title |
Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021) |
| spellingShingle |
Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021) Poteser, Michael Acrylamide Glycidamide Exposure Level Time-trend HBM4EU HBM4EU Aligned Studies Acrilamida Caracterização da Exposição Variação Temporal Determinantes da Saúde e da Doença |
| title_short |
Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021) |
| title_full |
Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021) |
| title_fullStr |
Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021) |
| title_full_unstemmed |
Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021) |
| title_sort |
Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021) |
| author |
Poteser, Michael |
| author_facet |
Poteser, Michael Laguzzi, Federica Schettgen, Thomas Vogel, Nina Weber, Till Murawski, Aline Schmidt, Phillipp Rüther, Maria Kolossa-Gehring, Marike Namorado, Sónia Van Nieuwenhuyse, An Appenzeller, Brice Dufthaksdóttir, Edda Olafsdottir, Kristin Haug, Line Småstuen Thomsen, Cathrine Barbone, Fabio Rosolen, Valentina RAMBAUD, Loic RIOU, Margaux Göen, Thomas Nübler, Stefanie Schäfer, Moritz Zarrabi, Karin H.A. Gilles, Liese Rodriguez Martin, Laura Schoeters, Greta Sepai, Ovnair Govarts, Eva Moshammer, Hanns |
| author_role |
author |
| author2 |
Laguzzi, Federica Schettgen, Thomas Vogel, Nina Weber, Till Murawski, Aline Schmidt, Phillipp Rüther, Maria Kolossa-Gehring, Marike Namorado, Sónia Van Nieuwenhuyse, An Appenzeller, Brice Dufthaksdóttir, Edda Olafsdottir, Kristin Haug, Line Småstuen Thomsen, Cathrine Barbone, Fabio Rosolen, Valentina RAMBAUD, Loic RIOU, Margaux Göen, Thomas Nübler, Stefanie Schäfer, Moritz Zarrabi, Karin H.A. Gilles, Liese Rodriguez Martin, Laura Schoeters, Greta Sepai, Ovnair Govarts, Eva Moshammer, Hanns |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Poteser, Michael Laguzzi, Federica Schettgen, Thomas Vogel, Nina Weber, Till Murawski, Aline Schmidt, Phillipp Rüther, Maria Kolossa-Gehring, Marike Namorado, Sónia Van Nieuwenhuyse, An Appenzeller, Brice Dufthaksdóttir, Edda Olafsdottir, Kristin Haug, Line Småstuen Thomsen, Cathrine Barbone, Fabio Rosolen, Valentina RAMBAUD, Loic RIOU, Margaux Göen, Thomas Nübler, Stefanie Schäfer, Moritz Zarrabi, Karin H.A. Gilles, Liese Rodriguez Martin, Laura Schoeters, Greta Sepai, Ovnair Govarts, Eva Moshammer, Hanns |
| dc.subject.por.fl_str_mv |
Acrylamide Glycidamide Exposure Level Time-trend HBM4EU HBM4EU Aligned Studies Acrilamida Caracterização da Exposição Variação Temporal Determinantes da Saúde e da Doença |
| topic |
Acrylamide Glycidamide Exposure Level Time-trend HBM4EU HBM4EU Aligned Studies Acrilamida Caracterização da Exposição Variação Temporal Determinantes da Saúde e da Doença |
| description |
This article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention? |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-11-15T12:42:28Z 2022-08-02 2022-08-02T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10400.18/8313 |
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http://hdl.handle.net/10400.18/8313 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Toxics. 2022 Aug 2;10(8):443. doi: 10.3390/toxics10080443 2305-6304 10.3390/toxics10080443 |
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info:eu-repo/semantics/openAccess |
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MDPI |
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MDPI |
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