Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast

Detalhes bibliográficos
Autor(a) principal: Paredes, João A.
Data de Publicação: 2012
Outros Autores: Carreto, Laura, Simões, João, Bezerra, Ana R., Gomes, Ana C., Santamaria, Rodrigo, Kapushesky, Misha, Moura, Gabriela R., Santos, Manuel A. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/26946
Resumo: Organisms use highly accurate molecular processes to transcribe their genes and a variety of mRNA quality control and ribosome proofreading mechanisms to maintain intact the fidelity of genetic information flow. Despite this, low level gene translational errors induced by mutations and environmental factors cause neurodegeneration and premature death in mice and mitochondrial disorders in humans. Paradoxically, such errors can generate advantageous phenotypic diversity in fungi and bacteria through poorly understood molecular processes.
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spelling Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeastYeastMistranslationtRNAProtein synthesismRNA profilingStressProteotoxic stressProtein misfoldingUnfolded protein responseOrganisms use highly accurate molecular processes to transcribe their genes and a variety of mRNA quality control and ribosome proofreading mechanisms to maintain intact the fidelity of genetic information flow. Despite this, low level gene translational errors induced by mutations and environmental factors cause neurodegeneration and premature death in mice and mitochondrial disorders in humans. Paradoxically, such errors can generate advantageous phenotypic diversity in fungi and bacteria through poorly understood molecular processes.BMC2019-11-12T14:51:49Z2012-06-20T00:00:00Z2012-06-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/26946eng1741-700710.1186/1741-7007-10-55Paredes, João A.Carreto, LauraSimões, JoãoBezerra, Ana R.Gomes, Ana C.Santamaria, RodrigoKapushesky, MishaMoura, Gabriela R.Santos, Manuel A. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:52:13Zoai:ria.ua.pt:10773/26946Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:59:50.662109Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast
title Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast
spellingShingle Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast
Paredes, João A.
Yeast
Mistranslation
tRNA
Protein synthesis
mRNA profiling
Stress
Proteotoxic stress
Protein misfolding
Unfolded protein response
title_short Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast
title_full Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast
title_fullStr Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast
title_full_unstemmed Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast
title_sort Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast
author Paredes, João A.
author_facet Paredes, João A.
Carreto, Laura
Simões, João
Bezerra, Ana R.
Gomes, Ana C.
Santamaria, Rodrigo
Kapushesky, Misha
Moura, Gabriela R.
Santos, Manuel A. S.
author_role author
author2 Carreto, Laura
Simões, João
Bezerra, Ana R.
Gomes, Ana C.
Santamaria, Rodrigo
Kapushesky, Misha
Moura, Gabriela R.
Santos, Manuel A. S.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Paredes, João A.
Carreto, Laura
Simões, João
Bezerra, Ana R.
Gomes, Ana C.
Santamaria, Rodrigo
Kapushesky, Misha
Moura, Gabriela R.
Santos, Manuel A. S.
dc.subject.por.fl_str_mv Yeast
Mistranslation
tRNA
Protein synthesis
mRNA profiling
Stress
Proteotoxic stress
Protein misfolding
Unfolded protein response
topic Yeast
Mistranslation
tRNA
Protein synthesis
mRNA profiling
Stress
Proteotoxic stress
Protein misfolding
Unfolded protein response
description Organisms use highly accurate molecular processes to transcribe their genes and a variety of mRNA quality control and ribosome proofreading mechanisms to maintain intact the fidelity of genetic information flow. Despite this, low level gene translational errors induced by mutations and environmental factors cause neurodegeneration and premature death in mice and mitochondrial disorders in humans. Paradoxically, such errors can generate advantageous phenotypic diversity in fungi and bacteria through poorly understood molecular processes.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-20T00:00:00Z
2012-06-20
2019-11-12T14:51:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/26946
url http://hdl.handle.net/10773/26946
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1741-7007
10.1186/1741-7007-10-55
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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