The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/5466 |
Resumo: | Urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasis-induced bladder cancer, here we review, interpret, and discuss findings of estradiol-like metabolites detected in both the parasite and in the human urine during urogenital schistosomiasis. Moreover, we predict pathways and enzymes that are involved in the production of these metabolites emphasizing their potential effects on the dysregulation of the tumor suppressor gene p53 expression during urogenital schistosomiasis. Enhanced understanding of these potential carcinogens may not only shed light on urogenital schistosomiasis-induced neoplasia of the bladder, but would also facilitate development of interventions and biomarkers for this and other infection-associated cancers at large. |
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The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancerAnimalsCell Transformation, NeoplasticDNA AdductsEstradiolHumansReactive Oxygen SpeciesSchistosoma haematobiumSchistosomiasis haematobiaTumor Suppressor Protein p53Urinary BladderUrinary Bladder NeoplasmsVias de Transdução de Sinal e Patologias AssociadasInfecções Sistémicas e ZoonosesUrogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasis-induced bladder cancer, here we review, interpret, and discuss findings of estradiol-like metabolites detected in both the parasite and in the human urine during urogenital schistosomiasis. Moreover, we predict pathways and enzymes that are involved in the production of these metabolites emphasizing their potential effects on the dysregulation of the tumor suppressor gene p53 expression during urogenital schistosomiasis. Enhanced understanding of these potential carcinogens may not only shed light on urogenital schistosomiasis-induced neoplasia of the bladder, but would also facilitate development of interventions and biomarkers for this and other infection-associated cancers at large.SAGE PublicationsRepositório Científico do Instituto Nacional de SaúdeVale, NunoGouveia, Maria J.Rinaldi, GabrielSantos, JúlioSantos, Lúcio LaraBrindley, Paul J.da Costa, José M. Correia2018-03-22T19:52:00Z2017-032017-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/5466engTumour Biol. 2017 Mar;39(3):1010428317692247. doi: 10.1177/1010428317692247.1010-428310.1177/1010428317692247info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:52Zoai:repositorio.insa.pt:10400.18/5466Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:09.445738Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer |
title |
The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer |
spellingShingle |
The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer Vale, Nuno Animals Cell Transformation, Neoplastic DNA Adducts Estradiol Humans Reactive Oxygen Species Schistosoma haematobium Schistosomiasis haematobia Tumor Suppressor Protein p53 Urinary Bladder Urinary Bladder Neoplasms Vias de Transdução de Sinal e Patologias Associadas Infecções Sistémicas e Zoonoses |
title_short |
The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer |
title_full |
The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer |
title_fullStr |
The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer |
title_full_unstemmed |
The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer |
title_sort |
The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer |
author |
Vale, Nuno |
author_facet |
Vale, Nuno Gouveia, Maria J. Rinaldi, Gabriel Santos, Júlio Santos, Lúcio Lara Brindley, Paul J. da Costa, José M. Correia |
author_role |
author |
author2 |
Gouveia, Maria J. Rinaldi, Gabriel Santos, Júlio Santos, Lúcio Lara Brindley, Paul J. da Costa, José M. Correia |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Vale, Nuno Gouveia, Maria J. Rinaldi, Gabriel Santos, Júlio Santos, Lúcio Lara Brindley, Paul J. da Costa, José M. Correia |
dc.subject.por.fl_str_mv |
Animals Cell Transformation, Neoplastic DNA Adducts Estradiol Humans Reactive Oxygen Species Schistosoma haematobium Schistosomiasis haematobia Tumor Suppressor Protein p53 Urinary Bladder Urinary Bladder Neoplasms Vias de Transdução de Sinal e Patologias Associadas Infecções Sistémicas e Zoonoses |
topic |
Animals Cell Transformation, Neoplastic DNA Adducts Estradiol Humans Reactive Oxygen Species Schistosoma haematobium Schistosomiasis haematobia Tumor Suppressor Protein p53 Urinary Bladder Urinary Bladder Neoplasms Vias de Transdução de Sinal e Patologias Associadas Infecções Sistémicas e Zoonoses |
description |
Urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasis-induced bladder cancer, here we review, interpret, and discuss findings of estradiol-like metabolites detected in both the parasite and in the human urine during urogenital schistosomiasis. Moreover, we predict pathways and enzymes that are involved in the production of these metabolites emphasizing their potential effects on the dysregulation of the tumor suppressor gene p53 expression during urogenital schistosomiasis. Enhanced understanding of these potential carcinogens may not only shed light on urogenital schistosomiasis-induced neoplasia of the bladder, but would also facilitate development of interventions and biomarkers for this and other infection-associated cancers at large. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03 2017-03-01T00:00:00Z 2018-03-22T19:52:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/5466 |
url |
http://hdl.handle.net/10400.18/5466 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Tumour Biol. 2017 Mar;39(3):1010428317692247. doi: 10.1177/1010428317692247. 1010-4283 10.1177/1010428317692247 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
SAGE Publications |
publisher.none.fl_str_mv |
SAGE Publications |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132143247425536 |