Isolation of bluish anthocyanin-derived pigments obtained from blueberry surplus using centrifugal partition chromatography

Detalhes bibliográficos
Autor(a) principal: Nunes, Ana N.
Data de Publicação: 2023
Outros Autores: Ivasiv, Viktoriya, Gouveia, Luís F., Fernández, Naiara, Oliveira, Joana, Bronze, Maria Rosário, Matias, Ana A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/158650
Resumo: Funding Information: This work was funded by Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), the Associate Laboratory LS4FUTURE (LA/P/0087/2020) and Associated Laboratory for Sustainable Chemistry, Clean Processes, and Technologies LAQV (UIDB/50006/2020 and UIDP/50006/2020). Funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), is gratefully acknowledged. A.N.N. acknowledge FCT for the financial support received through SFRH/BD/144592/2019. J.O. acknowledge FCT her research contract (2022.00042.CEECIND/CP1724/CT0017). The authors also acknowledge Delícias do Tojal, CultiBaga, and Mirtilsul for kindly supplying the biomass. Funding Information: This work was funded by Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health ( UIDB/04462/2020 and UIDP/04462/2020 ), the Associate Laboratory LS4FUTURE ( LA/P/0087/2020 ) and Associated Laboratory for Sustainable Chemistry, Clean Processes, and Technologies LAQV ( UIDB/50006/2020 and UIDP/50006/2020 ). Funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund ( FITEC ), is gratefully acknowledged. A.N.N. acknowledge FCT for the financial support received through SFRH/BD/144592/2019 . J.O. acknowledge FCT her research contract ( 2022.00042.CEECIND/CP1724/CT0017 ). The authors also acknowledge Delícias do Tojal, CultiBaga, and Mirtilsul for kindly supplying the biomass. Publisher Copyright: © 2023 The Author(s)
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spelling Isolation of bluish anthocyanin-derived pigments obtained from blueberry surplus using centrifugal partition chromatographyBlueberry residues valorizationBluish pigmentCentrifugal partition chromatographyPortisinAnalytical ChemistryBiochemistryOrganic ChemistryFunding Information: This work was funded by Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), the Associate Laboratory LS4FUTURE (LA/P/0087/2020) and Associated Laboratory for Sustainable Chemistry, Clean Processes, and Technologies LAQV (UIDB/50006/2020 and UIDP/50006/2020). Funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), is gratefully acknowledged. A.N.N. acknowledge FCT for the financial support received through SFRH/BD/144592/2019. J.O. acknowledge FCT her research contract (2022.00042.CEECIND/CP1724/CT0017). The authors also acknowledge Delícias do Tojal, CultiBaga, and Mirtilsul for kindly supplying the biomass. Funding Information: This work was funded by Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health ( UIDB/04462/2020 and UIDP/04462/2020 ), the Associate Laboratory LS4FUTURE ( LA/P/0087/2020 ) and Associated Laboratory for Sustainable Chemistry, Clean Processes, and Technologies LAQV ( UIDB/50006/2020 and UIDP/50006/2020 ). Funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund ( FITEC ), is gratefully acknowledged. A.N.N. acknowledge FCT for the financial support received through SFRH/BD/144592/2019 . J.O. acknowledge FCT her research contract ( 2022.00042.CEECIND/CP1724/CT0017 ). The authors also acknowledge Delícias do Tojal, CultiBaga, and Mirtilsul for kindly supplying the biomass. Publisher Copyright: © 2023 The Author(s)Replacement of synthetic colorants with natural ones is a current marketing trend. Nevertheless, the naturally occurring blue color is rare compared to other colours. In this work, centrifugal partition chromatography (CPC) process was developed as a more efficient and sustainable alternative to reversed phase column chromatography (RP-CC) for the preparative-scale purification of portisins. The strategy began with the extraction of anthocyanins from blueberry surplus and hemi-synthesis of respective portisins. Then, the CPC method development started with the biphasic solvent system selection followed by the optimization of the operating parameters and ended up with a comparison with RP-CC. Aiming at maximizing the portisin content, process throughput, efficiency, and minimizing the environmental risk factor, the effect of sample load (100–500 mg/100 mL of column volume), mobile phase flow rate (10–20 mL/min), and rotation speed (1000–1600 rpm) was evaluated. The two-phase solvent system consisted of tert‑butyl‑methyl ether, n-butanol, acetonitrile, and water (volume ratio 2:2:1:5) acidified with 0.1 vol.% of HCl was selected. The best conditions were 464 mg of sample/100 mL of column volume, 20 mL/min of mobile phase flow rate, and 1600 rpm of rotation speed at reversed phase mode, allowing the purification of portisins by 5-fold. Compared to the RP-CC, the CPC process efficiency was 2.4 times higher, while the CPC process environmental risk factor was 5.5 times lower. Overall, this study suggests that CPC can be considered an effective, and sustainable alternative process for the preparative isolation of portisins. With this purification approach, the blueberry surplus has been valorized and a naturally derived product has been prepared, allowing its subsequent use as a natural blue colorant.Instituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNNunes, Ana N.Ivasiv, ViktoriyaGouveia, Luís F.Fernández, NaiaraOliveira, JoanaBronze, Maria RosárioMatias, Ana A.2023-10-03T22:18:54Z2023-08-302023-08-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/158650eng0021-9673PURE: 72617390https://doi.org/10.1016/j.chroma.2023.464150info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:41:11Zoai:run.unl.pt:10362/158650Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:14.997884Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Isolation of bluish anthocyanin-derived pigments obtained from blueberry surplus using centrifugal partition chromatography
title Isolation of bluish anthocyanin-derived pigments obtained from blueberry surplus using centrifugal partition chromatography
spellingShingle Isolation of bluish anthocyanin-derived pigments obtained from blueberry surplus using centrifugal partition chromatography
Nunes, Ana N.
Blueberry residues valorization
Bluish pigment
Centrifugal partition chromatography
Portisin
Analytical Chemistry
Biochemistry
Organic Chemistry
title_short Isolation of bluish anthocyanin-derived pigments obtained from blueberry surplus using centrifugal partition chromatography
title_full Isolation of bluish anthocyanin-derived pigments obtained from blueberry surplus using centrifugal partition chromatography
title_fullStr Isolation of bluish anthocyanin-derived pigments obtained from blueberry surplus using centrifugal partition chromatography
title_full_unstemmed Isolation of bluish anthocyanin-derived pigments obtained from blueberry surplus using centrifugal partition chromatography
title_sort Isolation of bluish anthocyanin-derived pigments obtained from blueberry surplus using centrifugal partition chromatography
author Nunes, Ana N.
author_facet Nunes, Ana N.
Ivasiv, Viktoriya
Gouveia, Luís F.
Fernández, Naiara
Oliveira, Joana
Bronze, Maria Rosário
Matias, Ana A.
author_role author
author2 Ivasiv, Viktoriya
Gouveia, Luís F.
Fernández, Naiara
Oliveira, Joana
Bronze, Maria Rosário
Matias, Ana A.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
RUN
dc.contributor.author.fl_str_mv Nunes, Ana N.
Ivasiv, Viktoriya
Gouveia, Luís F.
Fernández, Naiara
Oliveira, Joana
Bronze, Maria Rosário
Matias, Ana A.
dc.subject.por.fl_str_mv Blueberry residues valorization
Bluish pigment
Centrifugal partition chromatography
Portisin
Analytical Chemistry
Biochemistry
Organic Chemistry
topic Blueberry residues valorization
Bluish pigment
Centrifugal partition chromatography
Portisin
Analytical Chemistry
Biochemistry
Organic Chemistry
description Funding Information: This work was funded by Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), the Associate Laboratory LS4FUTURE (LA/P/0087/2020) and Associated Laboratory for Sustainable Chemistry, Clean Processes, and Technologies LAQV (UIDB/50006/2020 and UIDP/50006/2020). Funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), is gratefully acknowledged. A.N.N. acknowledge FCT for the financial support received through SFRH/BD/144592/2019. J.O. acknowledge FCT her research contract (2022.00042.CEECIND/CP1724/CT0017). The authors also acknowledge Delícias do Tojal, CultiBaga, and Mirtilsul for kindly supplying the biomass. Funding Information: This work was funded by Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health ( UIDB/04462/2020 and UIDP/04462/2020 ), the Associate Laboratory LS4FUTURE ( LA/P/0087/2020 ) and Associated Laboratory for Sustainable Chemistry, Clean Processes, and Technologies LAQV ( UIDB/50006/2020 and UIDP/50006/2020 ). Funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund ( FITEC ), is gratefully acknowledged. A.N.N. acknowledge FCT for the financial support received through SFRH/BD/144592/2019 . J.O. acknowledge FCT her research contract ( 2022.00042.CEECIND/CP1724/CT0017 ). The authors also acknowledge Delícias do Tojal, CultiBaga, and Mirtilsul for kindly supplying the biomass. Publisher Copyright: © 2023 The Author(s)
publishDate 2023
dc.date.none.fl_str_mv 2023-10-03T22:18:54Z
2023-08-30
2023-08-30T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158650
url http://hdl.handle.net/10362/158650
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0021-9673
PURE: 72617390
https://doi.org/10.1016/j.chroma.2023.464150
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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