Restoring heart function and electrical integrity: closing the circuit
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/108284 https://doi.org/10.1038/s41536-017-0015-2 |
Resumo: | Cardiovascular diseases are the main cause of death in the world and are often associated with the occurrence of arrhythmias due to disruption of myocardial electrical integrity. Pathologies involving dysfunction of the specialized cardiac excitatory/conductive tissue are also common and constitute an added source of morbidity and mortality since current standard therapies withstand a great number of limitations. As electrical integrity is essential for a well-functioning heart, innovative strategies have been bioengineered to improve heart conduction and/or promote myocardial repair, based on: (1) gene and/or cell delivery; or (2) conductive biomaterials as tools for cardiac tissue engineering. Herein we aim to review the state-of-art in the area, while briefly describing the biological principles underlying the heart electrical/conduction system and how this system can be disrupted in heart disease. Suggestions regarding targets for future studies are also presented. |
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Restoring heart function and electrical integrity: closing the circuitCardiovascular diseases are the main cause of death in the world and are often associated with the occurrence of arrhythmias due to disruption of myocardial electrical integrity. Pathologies involving dysfunction of the specialized cardiac excitatory/conductive tissue are also common and constitute an added source of morbidity and mortality since current standard therapies withstand a great number of limitations. As electrical integrity is essential for a well-functioning heart, innovative strategies have been bioengineered to improve heart conduction and/or promote myocardial repair, based on: (1) gene and/or cell delivery; or (2) conductive biomaterials as tools for cardiac tissue engineering. Herein we aim to review the state-of-art in the area, while briefly describing the biological principles underlying the heart electrical/conduction system and how this system can be disrupted in heart disease. Suggestions regarding targets for future studies are also presented.Springer Nature2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/108284http://hdl.handle.net/10316/108284https://doi.org/10.1038/s41536-017-0015-2eng2057-3995Monteiro, Luís MiguelVasques-Nóvoa, FranciscoFerreira, LinoPinto-do-Ó, PerpétuaNascimento, Diana Santosinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-22T11:24:39Zoai:estudogeral.uc.pt:10316/108284Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:24:35.471976Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Restoring heart function and electrical integrity: closing the circuit |
title |
Restoring heart function and electrical integrity: closing the circuit |
spellingShingle |
Restoring heart function and electrical integrity: closing the circuit Monteiro, Luís Miguel |
title_short |
Restoring heart function and electrical integrity: closing the circuit |
title_full |
Restoring heart function and electrical integrity: closing the circuit |
title_fullStr |
Restoring heart function and electrical integrity: closing the circuit |
title_full_unstemmed |
Restoring heart function and electrical integrity: closing the circuit |
title_sort |
Restoring heart function and electrical integrity: closing the circuit |
author |
Monteiro, Luís Miguel |
author_facet |
Monteiro, Luís Miguel Vasques-Nóvoa, Francisco Ferreira, Lino Pinto-do-Ó, Perpétua Nascimento, Diana Santos |
author_role |
author |
author2 |
Vasques-Nóvoa, Francisco Ferreira, Lino Pinto-do-Ó, Perpétua Nascimento, Diana Santos |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Monteiro, Luís Miguel Vasques-Nóvoa, Francisco Ferreira, Lino Pinto-do-Ó, Perpétua Nascimento, Diana Santos |
description |
Cardiovascular diseases are the main cause of death in the world and are often associated with the occurrence of arrhythmias due to disruption of myocardial electrical integrity. Pathologies involving dysfunction of the specialized cardiac excitatory/conductive tissue are also common and constitute an added source of morbidity and mortality since current standard therapies withstand a great number of limitations. As electrical integrity is essential for a well-functioning heart, innovative strategies have been bioengineered to improve heart conduction and/or promote myocardial repair, based on: (1) gene and/or cell delivery; or (2) conductive biomaterials as tools for cardiac tissue engineering. Herein we aim to review the state-of-art in the area, while briefly describing the biological principles underlying the heart electrical/conduction system and how this system can be disrupted in heart disease. Suggestions regarding targets for future studies are also presented. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/108284 http://hdl.handle.net/10316/108284 https://doi.org/10.1038/s41536-017-0015-2 |
url |
http://hdl.handle.net/10316/108284 https://doi.org/10.1038/s41536-017-0015-2 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2057-3995 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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