Lymphogranuloma Venereum: a Retrospective Analysis of an Emerging Sexually Transmitted Disease in a Lisbon Tertiary Center

Detalhes bibliográficos
Autor(a) principal: Neves, JM
Data de Publicação: 2021
Outros Autores: Ramos Pinheiro, R, Côrte‐Real, R, Borrego, MJ, Rodrigues, A, Fernandes, C
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/4876
Resumo: Background: Lymphogranuloma venereum (LGV) is a sexual transmitted infection (STI), currently endemic within the population of men who have sex with men (MSM) of Western Countries. L2B variant has been reported as the predominant strain in the current LGV epidemics, although a shift towards L2-434 has been observed in some European countries. Objectives: To evaluate and characterize the population with LGV infection diagnosed in Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal. Methods: A retrospective analysis of all LGV diagnoses between 2016 and 2019 was performed. The diagnosis was established through ompA-genotyping of samples yielding a positive result to Chlamydia trachomatis (CT). All considered samples were retrieved from the clinician activity, through swabbing and urine analysis and CT infection diagnosis was obtained using real-time PCR. Results: During the period studied 16 279 CT diagnostics tests were employed, with a striking increase from 2016 (n = 467) to 2019 (n = 9362). A total of 1602 diagnoses of CT were established, from which 168 (10.5%) corresponded to LGV, with both infections showing a rising evolution, between 2016 and 2019, of 2.9 and 2.7 times, respectively. The majority of the LGV strains were genotyped as L2/434 (67.3%; n = 113). LGV predominantly affected MSM and men who have sex with men and women (97.0%; n = 163). Anorectal infection was the most prevalent one (90.5%; n = 152), being proctitis the main clinical presentation (76.2%; n = 128). Absence of symptoms was reported in almost 15% of the cases (n = 24). The presence of concomitant infection with human immunodeficiency virus was dominant (73.2%; n = 123) and the prevalence of one or more STI co-infections was about 60.1% (n = 99). Conclusions: An increasing evolution of CT and LGV testing and diagnosing was observable throughout the studied period. Characteristics of the population are similar with those described within LGV epidemics. In accordance with recent European studies, predominance towards L2 genotype was identified.
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spelling Lymphogranuloma Venereum: a Retrospective Analysis of an Emerging Sexually Transmitted Disease in a Lisbon Tertiary CenterHSAC DERCHLC PAT CLINHumansFemaleMaleChlamydia trachomatis / geneticsEuropeHomosexuality, MaleLymphogranuloma Venereum* / diagnosisLymphogranuloma Venereum* / epidemiologyRetrospective StudiesPortugalSexual and Gender Minorities*Background: Lymphogranuloma venereum (LGV) is a sexual transmitted infection (STI), currently endemic within the population of men who have sex with men (MSM) of Western Countries. L2B variant has been reported as the predominant strain in the current LGV epidemics, although a shift towards L2-434 has been observed in some European countries. Objectives: To evaluate and characterize the population with LGV infection diagnosed in Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal. Methods: A retrospective analysis of all LGV diagnoses between 2016 and 2019 was performed. The diagnosis was established through ompA-genotyping of samples yielding a positive result to Chlamydia trachomatis (CT). All considered samples were retrieved from the clinician activity, through swabbing and urine analysis and CT infection diagnosis was obtained using real-time PCR. Results: During the period studied 16 279 CT diagnostics tests were employed, with a striking increase from 2016 (n = 467) to 2019 (n = 9362). A total of 1602 diagnoses of CT were established, from which 168 (10.5%) corresponded to LGV, with both infections showing a rising evolution, between 2016 and 2019, of 2.9 and 2.7 times, respectively. The majority of the LGV strains were genotyped as L2/434 (67.3%; n = 113). LGV predominantly affected MSM and men who have sex with men and women (97.0%; n = 163). Anorectal infection was the most prevalent one (90.5%; n = 152), being proctitis the main clinical presentation (76.2%; n = 128). Absence of symptoms was reported in almost 15% of the cases (n = 24). The presence of concomitant infection with human immunodeficiency virus was dominant (73.2%; n = 123) and the prevalence of one or more STI co-infections was about 60.1% (n = 99). Conclusions: An increasing evolution of CT and LGV testing and diagnosing was observable throughout the studied period. Characteristics of the population are similar with those described within LGV epidemics. In accordance with recent European studies, predominance towards L2 genotype was identified.WileyRepositório do Centro Hospitalar Universitário de Lisboa Central, EPENeves, JMRamos Pinheiro, RCôrte‐Real, RBorrego, MJRodrigues, AFernandes, C2024-04-12T15:28:56Z2021-082021-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4876engJ Eur Acad Dermatol Venereol . 2021 Aug;35(8):1712-1716.10.1111/jdv.17302info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-10-28T10:31:34Zoai:repositorio.chlc.pt:10400.17/4876Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-10-28T10:31:34Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Lymphogranuloma Venereum: a Retrospective Analysis of an Emerging Sexually Transmitted Disease in a Lisbon Tertiary Center
title Lymphogranuloma Venereum: a Retrospective Analysis of an Emerging Sexually Transmitted Disease in a Lisbon Tertiary Center
spellingShingle Lymphogranuloma Venereum: a Retrospective Analysis of an Emerging Sexually Transmitted Disease in a Lisbon Tertiary Center
Neves, JM
HSAC DER
CHLC PAT CLIN
Humans
Female
Male
Chlamydia trachomatis / genetics
Europe
Homosexuality, Male
Lymphogranuloma Venereum* / diagnosis
Lymphogranuloma Venereum* / epidemiology
Retrospective Studies
Portugal
Sexual and Gender Minorities*
title_short Lymphogranuloma Venereum: a Retrospective Analysis of an Emerging Sexually Transmitted Disease in a Lisbon Tertiary Center
title_full Lymphogranuloma Venereum: a Retrospective Analysis of an Emerging Sexually Transmitted Disease in a Lisbon Tertiary Center
title_fullStr Lymphogranuloma Venereum: a Retrospective Analysis of an Emerging Sexually Transmitted Disease in a Lisbon Tertiary Center
title_full_unstemmed Lymphogranuloma Venereum: a Retrospective Analysis of an Emerging Sexually Transmitted Disease in a Lisbon Tertiary Center
title_sort Lymphogranuloma Venereum: a Retrospective Analysis of an Emerging Sexually Transmitted Disease in a Lisbon Tertiary Center
author Neves, JM
author_facet Neves, JM
Ramos Pinheiro, R
Côrte‐Real, R
Borrego, MJ
Rodrigues, A
Fernandes, C
author_role author
author2 Ramos Pinheiro, R
Côrte‐Real, R
Borrego, MJ
Rodrigues, A
Fernandes, C
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Neves, JM
Ramos Pinheiro, R
Côrte‐Real, R
Borrego, MJ
Rodrigues, A
Fernandes, C
dc.subject.por.fl_str_mv HSAC DER
CHLC PAT CLIN
Humans
Female
Male
Chlamydia trachomatis / genetics
Europe
Homosexuality, Male
Lymphogranuloma Venereum* / diagnosis
Lymphogranuloma Venereum* / epidemiology
Retrospective Studies
Portugal
Sexual and Gender Minorities*
topic HSAC DER
CHLC PAT CLIN
Humans
Female
Male
Chlamydia trachomatis / genetics
Europe
Homosexuality, Male
Lymphogranuloma Venereum* / diagnosis
Lymphogranuloma Venereum* / epidemiology
Retrospective Studies
Portugal
Sexual and Gender Minorities*
description Background: Lymphogranuloma venereum (LGV) is a sexual transmitted infection (STI), currently endemic within the population of men who have sex with men (MSM) of Western Countries. L2B variant has been reported as the predominant strain in the current LGV epidemics, although a shift towards L2-434 has been observed in some European countries. Objectives: To evaluate and characterize the population with LGV infection diagnosed in Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal. Methods: A retrospective analysis of all LGV diagnoses between 2016 and 2019 was performed. The diagnosis was established through ompA-genotyping of samples yielding a positive result to Chlamydia trachomatis (CT). All considered samples were retrieved from the clinician activity, through swabbing and urine analysis and CT infection diagnosis was obtained using real-time PCR. Results: During the period studied 16 279 CT diagnostics tests were employed, with a striking increase from 2016 (n = 467) to 2019 (n = 9362). A total of 1602 diagnoses of CT were established, from which 168 (10.5%) corresponded to LGV, with both infections showing a rising evolution, between 2016 and 2019, of 2.9 and 2.7 times, respectively. The majority of the LGV strains were genotyped as L2/434 (67.3%; n = 113). LGV predominantly affected MSM and men who have sex with men and women (97.0%; n = 163). Anorectal infection was the most prevalent one (90.5%; n = 152), being proctitis the main clinical presentation (76.2%; n = 128). Absence of symptoms was reported in almost 15% of the cases (n = 24). The presence of concomitant infection with human immunodeficiency virus was dominant (73.2%; n = 123) and the prevalence of one or more STI co-infections was about 60.1% (n = 99). Conclusions: An increasing evolution of CT and LGV testing and diagnosing was observable throughout the studied period. Characteristics of the population are similar with those described within LGV epidemics. In accordance with recent European studies, predominance towards L2 genotype was identified.
publishDate 2021
dc.date.none.fl_str_mv 2021-08
2021-08-01T00:00:00Z
2024-04-12T15:28:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/4876
url http://hdl.handle.net/10400.17/4876
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Eur Acad Dermatol Venereol . 2021 Aug;35(8):1712-1716.
10.1111/jdv.17302
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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