An Overview on the Recent Advances in Alternative Solvents as Stabilizers of Proteins and Enzymes

Detalhes bibliográficos
Autor(a) principal: Almeida, Jéssica S.
Data de Publicação: 2022
Outros Autores: Capela, Emanuel V., Loureiro, Ana M., Tavares, Ana P. M., Freire, Mara G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/35903
Resumo: Currently, the use of alternative solvents is increasing, namely ionic liquids (ILs) and deep eutectic solvents (DESs) in diverse fields of knowledge, such as biochemistry, chemistry, chemical engineering, biotechnology and biomedicine. Particularly, when compared to traditional solvents, these alternative solvents have great importance for biomolecules due to the enhanced solubility, structure stability and the biological activity of biomolecules, such as protein and enzymes. Thus, in this review article, the recent developments and efforts on the technological developments carried out with ILs and DESs for the stabilization and activation of proteins and enzymes are provided. The most studied IL-and DES-based formulations for proteins and enzymes are discussed and the molecular mechanisms and interactions related to the increased stability promoted by these alternative solvents are disclosed, while emphasizing their main advantages
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spelling An Overview on the Recent Advances in Alternative Solvents as Stabilizers of Proteins and EnzymesCurrently, the use of alternative solvents is increasing, namely ionic liquids (ILs) and deep eutectic solvents (DESs) in diverse fields of knowledge, such as biochemistry, chemistry, chemical engineering, biotechnology and biomedicine. Particularly, when compared to traditional solvents, these alternative solvents have great importance for biomolecules due to the enhanced solubility, structure stability and the biological activity of biomolecules, such as protein and enzymes. Thus, in this review article, the recent developments and efforts on the technological developments carried out with ILs and DESs for the stabilization and activation of proteins and enzymes are provided. The most studied IL-and DES-based formulations for proteins and enzymes are discussed and the molecular mechanisms and interactions related to the increased stability promoted by these alternative solvents are disclosed, while emphasizing their main advantagesMDPI2023-01-20T10:06:32Z2022-08-01T00:00:00Z2022-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/35903eng2305-708410.3390/chemengineering6040051Almeida, Jéssica S.Capela, Emanuel V.Loureiro, Ana M.Tavares, Ana P. M.Freire, Mara G.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-06T04:41:43Zoai:ria.ua.pt:10773/35903Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-06T04:41:43Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv An Overview on the Recent Advances in Alternative Solvents as Stabilizers of Proteins and Enzymes
title An Overview on the Recent Advances in Alternative Solvents as Stabilizers of Proteins and Enzymes
spellingShingle An Overview on the Recent Advances in Alternative Solvents as Stabilizers of Proteins and Enzymes
Almeida, Jéssica S.
title_short An Overview on the Recent Advances in Alternative Solvents as Stabilizers of Proteins and Enzymes
title_full An Overview on the Recent Advances in Alternative Solvents as Stabilizers of Proteins and Enzymes
title_fullStr An Overview on the Recent Advances in Alternative Solvents as Stabilizers of Proteins and Enzymes
title_full_unstemmed An Overview on the Recent Advances in Alternative Solvents as Stabilizers of Proteins and Enzymes
title_sort An Overview on the Recent Advances in Alternative Solvents as Stabilizers of Proteins and Enzymes
author Almeida, Jéssica S.
author_facet Almeida, Jéssica S.
Capela, Emanuel V.
Loureiro, Ana M.
Tavares, Ana P. M.
Freire, Mara G.
author_role author
author2 Capela, Emanuel V.
Loureiro, Ana M.
Tavares, Ana P. M.
Freire, Mara G.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Jéssica S.
Capela, Emanuel V.
Loureiro, Ana M.
Tavares, Ana P. M.
Freire, Mara G.
description Currently, the use of alternative solvents is increasing, namely ionic liquids (ILs) and deep eutectic solvents (DESs) in diverse fields of knowledge, such as biochemistry, chemistry, chemical engineering, biotechnology and biomedicine. Particularly, when compared to traditional solvents, these alternative solvents have great importance for biomolecules due to the enhanced solubility, structure stability and the biological activity of biomolecules, such as protein and enzymes. Thus, in this review article, the recent developments and efforts on the technological developments carried out with ILs and DESs for the stabilization and activation of proteins and enzymes are provided. The most studied IL-and DES-based formulations for proteins and enzymes are discussed and the molecular mechanisms and interactions related to the increased stability promoted by these alternative solvents are disclosed, while emphasizing their main advantages
publishDate 2022
dc.date.none.fl_str_mv 2022-08-01T00:00:00Z
2022-08
2023-01-20T10:06:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/35903
url http://hdl.handle.net/10773/35903
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2305-7084
10.3390/chemengineering6040051
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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