Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors

Detalhes bibliográficos
Autor(a) principal: Cunha-Santos, Catarina
Data de Publicação: 2016
Outros Autores: Figueira, Tiago N., Borrego, Pedro, Oliveira, Soraia S., Rocha, Cheila, Couto, Andreia, Cantante, Cátia, Santos- Costa, Quirina, Azevedo-Pereira, José M., Fontes, Carlos M. G. A., Taveira, Nuno, Aires-Da-Silva, Frederico, Castanho, Miguel A. R. B., Veiga, Ana Salomé, Gonçalves, João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/15096
Resumo: This is a non-final version of an article published in final form in AIDS. 2016 Jul 17;30(11):1691-701.
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spelling Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitorsHIV fusion inhibitorHR1Single-domain antibodySynthetic libraryVariable light-chainThis is a non-final version of an article published in final form in AIDS. 2016 Jul 17;30(11):1691-701."Objective: To develop a novel and potent fusion inhibitor of HIV infection based on a rational strategy for synthetic antibody library construction. Design: The reduced molecular weight of single-domain antibodies (sdAbs) allows targeting of cryptic epitopes, the most conserved and critical ones in the context of HIV entry. Heavy-chain sdAbs from camelids are particularly suited for this type of epitope recognition because of the presence of long and flexible antigen-binding regions [complementary-determining regions (CDRs)]."Wolters KluwerRepositório ComumCunha-Santos, CatarinaFigueira, Tiago N.Borrego, PedroOliveira, Soraia S.Rocha, CheilaCouto, AndreiaCantante, CátiaSantos- Costa, QuirinaAzevedo-Pereira, José M.Fontes, Carlos M. G. A.Taveira, NunoAires-Da-Silva, FredericoCastanho, Miguel A. R. B.Veiga, Ana SaloméGonçalves, João2017-08-01T00:30:11Z2016-07-01T00:00:00Z2016-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/15096engAIDS. 2016 Jul 17;30(11):1691-701. doi: 10.1097/QAD.0000000000001108.1691-17010.1097/QAD.0000000000001108info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:52:32Zoai:comum.rcaap.pt:10400.26/15096Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:08:23.456405Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors
title Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors
spellingShingle Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors
Cunha-Santos, Catarina
HIV fusion inhibitor
HR1
Single-domain antibody
Synthetic library
Variable light-chain
title_short Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors
title_full Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors
title_fullStr Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors
title_full_unstemmed Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors
title_sort Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors
author Cunha-Santos, Catarina
author_facet Cunha-Santos, Catarina
Figueira, Tiago N.
Borrego, Pedro
Oliveira, Soraia S.
Rocha, Cheila
Couto, Andreia
Cantante, Cátia
Santos- Costa, Quirina
Azevedo-Pereira, José M.
Fontes, Carlos M. G. A.
Taveira, Nuno
Aires-Da-Silva, Frederico
Castanho, Miguel A. R. B.
Veiga, Ana Salomé
Gonçalves, João
author_role author
author2 Figueira, Tiago N.
Borrego, Pedro
Oliveira, Soraia S.
Rocha, Cheila
Couto, Andreia
Cantante, Cátia
Santos- Costa, Quirina
Azevedo-Pereira, José M.
Fontes, Carlos M. G. A.
Taveira, Nuno
Aires-Da-Silva, Frederico
Castanho, Miguel A. R. B.
Veiga, Ana Salomé
Gonçalves, João
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Cunha-Santos, Catarina
Figueira, Tiago N.
Borrego, Pedro
Oliveira, Soraia S.
Rocha, Cheila
Couto, Andreia
Cantante, Cátia
Santos- Costa, Quirina
Azevedo-Pereira, José M.
Fontes, Carlos M. G. A.
Taveira, Nuno
Aires-Da-Silva, Frederico
Castanho, Miguel A. R. B.
Veiga, Ana Salomé
Gonçalves, João
dc.subject.por.fl_str_mv HIV fusion inhibitor
HR1
Single-domain antibody
Synthetic library
Variable light-chain
topic HIV fusion inhibitor
HR1
Single-domain antibody
Synthetic library
Variable light-chain
description This is a non-final version of an article published in final form in AIDS. 2016 Jul 17;30(11):1691-701.
publishDate 2016
dc.date.none.fl_str_mv 2016-07-01T00:00:00Z
2016-07-01T00:00:00Z
2017-08-01T00:30:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/15096
url http://hdl.handle.net/10400.26/15096
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv AIDS. 2016 Jul 17;30(11):1691-701. doi: 10.1097/QAD.0000000000001108.
1691-1701
0.1097/QAD.0000000000001108
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer
publisher.none.fl_str_mv Wolters Kluwer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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