Lectins: Function, structure, biological properties andpotential applications
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/43440 |
Resumo: | Lectins are a special class of proteins widely distributed in nature, which selectively recognize and reversibly bind to carbohydrates and glycoconjugates through their binding sites. These proteins, which can be detected through haemagglutination assays, interact with different carbohydrates present in cell surfaces. Lectins are generally classified according to their structure, specificity for carbohydrates and species location. Depending on their properties and distribution in tissues, lectins can play important physiological roles. The characteristic property of lectins to recognize other molecules in a distinct way makes it relevant in research involving purification, structural analysis, in vitro/in vivo applications of these macromolecules and biotechnological uses in different areas such as molecular and cell biology, immunology, pharmacology, medicine, clinical analysis, nanotechnology as well as in systems for drug release. Lectins can be used for analysis of structure and physiology of cells, tissues and pathogenic microorganisms. In agriculture, these proteins are used as insecticidal agents. Lectins have already been shown to exhibit different biological activities and effects, such as mitogenic and antiproliferative activities on cell lines of human cancer, inhibition of bacterial and fungal growth, action as promoting agents in cell aggregation, immunomodulatory activities and toxic effects. These proteins are promising as drugs for treatment and in diagnosis of human diseases; they are important tools in cytochemistry, histochemistry and immunohistochemistry and are also useful in forensic medicine. In summary, this review provides an overview of lectin research, with focus on physiological functions, structural performance, classification, potential biotechnological properties and applications. |
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Lectins: Function, structure, biological properties andpotential applicationslectinsphysiological functionsbiotechnological applicationsLectins are a special class of proteins widely distributed in nature, which selectively recognize and reversibly bind to carbohydrates and glycoconjugates through their binding sites. These proteins, which can be detected through haemagglutination assays, interact with different carbohydrates present in cell surfaces. Lectins are generally classified according to their structure, specificity for carbohydrates and species location. Depending on their properties and distribution in tissues, lectins can play important physiological roles. The characteristic property of lectins to recognize other molecules in a distinct way makes it relevant in research involving purification, structural analysis, in vitro/in vivo applications of these macromolecules and biotechnological uses in different areas such as molecular and cell biology, immunology, pharmacology, medicine, clinical analysis, nanotechnology as well as in systems for drug release. Lectins can be used for analysis of structure and physiology of cells, tissues and pathogenic microorganisms. In agriculture, these proteins are used as insecticidal agents. Lectins have already been shown to exhibit different biological activities and effects, such as mitogenic and antiproliferative activities on cell lines of human cancer, inhibition of bacterial and fungal growth, action as promoting agents in cell aggregation, immunomodulatory activities and toxic effects. These proteins are promising as drugs for treatment and in diagnosis of human diseases; they are important tools in cytochemistry, histochemistry and immunohistochemistry and are also useful in forensic medicine. In summary, this review provides an overview of lectin research, with focus on physiological functions, structural performance, classification, potential biotechnological properties and applications.Authors acknowledge the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for fellowships to PMGP, MTSC and LCBBC. In addition, we are grateful to Grant SFRH/BPD/ 37349/2007 from the Foundation for Science and Technology and POPH/FSE, awarded to AFSSResearch TrendsUniversidade do MinhoSantos, Andréa F. S.Silva, M. D. C. daNapoleão, T. H.Paiva, P. M. G.Correia, M. T. S.Coelho, L. C. B. B.20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/43440engSantos, Andréa F. S.; Silva, M. D. C. da; Napoleão, T. H.; Paiva, P. M. G.; Correia, M. T. S.; Coelho, L. C. B. B., Lectins: Function, structure, biological properties andpotential applications. Current Topics in Peptide and Protein Research, 15, 41-62, 20140972-4524http://www.researchtrends.net/tia/title.asp?id=26&type=3info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:53:55Zoai:repositorium.sdum.uminho.pt:1822/43440Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:43:22.720657Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Lectins: Function, structure, biological properties andpotential applications |
title |
Lectins: Function, structure, biological properties andpotential applications |
spellingShingle |
Lectins: Function, structure, biological properties andpotential applications Santos, Andréa F. S. lectins physiological functions biotechnological applications |
title_short |
Lectins: Function, structure, biological properties andpotential applications |
title_full |
Lectins: Function, structure, biological properties andpotential applications |
title_fullStr |
Lectins: Function, structure, biological properties andpotential applications |
title_full_unstemmed |
Lectins: Function, structure, biological properties andpotential applications |
title_sort |
Lectins: Function, structure, biological properties andpotential applications |
author |
Santos, Andréa F. S. |
author_facet |
Santos, Andréa F. S. Silva, M. D. C. da Napoleão, T. H. Paiva, P. M. G. Correia, M. T. S. Coelho, L. C. B. B. |
author_role |
author |
author2 |
Silva, M. D. C. da Napoleão, T. H. Paiva, P. M. G. Correia, M. T. S. Coelho, L. C. B. B. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Santos, Andréa F. S. Silva, M. D. C. da Napoleão, T. H. Paiva, P. M. G. Correia, M. T. S. Coelho, L. C. B. B. |
dc.subject.por.fl_str_mv |
lectins physiological functions biotechnological applications |
topic |
lectins physiological functions biotechnological applications |
description |
Lectins are a special class of proteins widely distributed in nature, which selectively recognize and reversibly bind to carbohydrates and glycoconjugates through their binding sites. These proteins, which can be detected through haemagglutination assays, interact with different carbohydrates present in cell surfaces. Lectins are generally classified according to their structure, specificity for carbohydrates and species location. Depending on their properties and distribution in tissues, lectins can play important physiological roles. The characteristic property of lectins to recognize other molecules in a distinct way makes it relevant in research involving purification, structural analysis, in vitro/in vivo applications of these macromolecules and biotechnological uses in different areas such as molecular and cell biology, immunology, pharmacology, medicine, clinical analysis, nanotechnology as well as in systems for drug release. Lectins can be used for analysis of structure and physiology of cells, tissues and pathogenic microorganisms. In agriculture, these proteins are used as insecticidal agents. Lectins have already been shown to exhibit different biological activities and effects, such as mitogenic and antiproliferative activities on cell lines of human cancer, inhibition of bacterial and fungal growth, action as promoting agents in cell aggregation, immunomodulatory activities and toxic effects. These proteins are promising as drugs for treatment and in diagnosis of human diseases; they are important tools in cytochemistry, histochemistry and immunohistochemistry and are also useful in forensic medicine. In summary, this review provides an overview of lectin research, with focus on physiological functions, structural performance, classification, potential biotechnological properties and applications. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/43440 |
url |
http://hdl.handle.net/1822/43440 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Santos, Andréa F. S.; Silva, M. D. C. da; Napoleão, T. H.; Paiva, P. M. G.; Correia, M. T. S.; Coelho, L. C. B. B., Lectins: Function, structure, biological properties andpotential applications. Current Topics in Peptide and Protein Research, 15, 41-62, 2014 0972-4524 http://www.researchtrends.net/tia/title.asp?id=26&type=3 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research Trends |
publisher.none.fl_str_mv |
Research Trends |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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