Inactivity-induced skeletal muscle atrophy: a brief review
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S1645-05232008000200011 |
Resumo: | Skeletal muscle is an adaptable tissue that responds rapidly to both increased contractile activity and inactivity. For example, lengthy periods of skeletal muscle disuse (e.g., bed rest) result in a decline of muscle protein and muscular strength. Our understanding of the processes that contribute to disuse muscle atrophy has expanded markedly during the past two decades and this review will provide an overview of the mechanisms responsible for disuse-mediated muscle atrophy. The first segment of this review will outline the experimental models commonly used to investigate disuse muscle atrophy. The second section will discuss our current understanding of muscle proteases whereas the final sector will identify the role that reactive oxygen species play in inactivity-induced muscle atrophy. |
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Inactivity-induced skeletal muscle atrophy: a brief reviewredoxoxidantsantioxidantsproteasomecalpaincaspase-3reactive oxygen speciesSkeletal muscle is an adaptable tissue that responds rapidly to both increased contractile activity and inactivity. For example, lengthy periods of skeletal muscle disuse (e.g., bed rest) result in a decline of muscle protein and muscular strength. Our understanding of the processes that contribute to disuse muscle atrophy has expanded markedly during the past two decades and this review will provide an overview of the mechanisms responsible for disuse-mediated muscle atrophy. The first segment of this review will outline the experimental models commonly used to investigate disuse muscle atrophy. The second section will discuss our current understanding of muscle proteases whereas the final sector will identify the role that reactive oxygen species play in inactivity-induced muscle atrophy.Faculdade de Desporto da Universidade do Porto2008-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S1645-05232008000200011Revista Portuguesa de Ciências do Desporto v.8 n.2 2008reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S1645-05232008000200011Powers,Scott K.Kavazis,Andreas N.info:eu-repo/semantics/openAccess2024-02-06T17:16:45Zoai:scielo:S1645-05232008000200011Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:25:36.647844Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Inactivity-induced skeletal muscle atrophy: a brief review |
title |
Inactivity-induced skeletal muscle atrophy: a brief review |
spellingShingle |
Inactivity-induced skeletal muscle atrophy: a brief review Powers,Scott K. redox oxidants antioxidants proteasome calpain caspase-3 reactive oxygen species |
title_short |
Inactivity-induced skeletal muscle atrophy: a brief review |
title_full |
Inactivity-induced skeletal muscle atrophy: a brief review |
title_fullStr |
Inactivity-induced skeletal muscle atrophy: a brief review |
title_full_unstemmed |
Inactivity-induced skeletal muscle atrophy: a brief review |
title_sort |
Inactivity-induced skeletal muscle atrophy: a brief review |
author |
Powers,Scott K. |
author_facet |
Powers,Scott K. Kavazis,Andreas N. |
author_role |
author |
author2 |
Kavazis,Andreas N. |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Powers,Scott K. Kavazis,Andreas N. |
dc.subject.por.fl_str_mv |
redox oxidants antioxidants proteasome calpain caspase-3 reactive oxygen species |
topic |
redox oxidants antioxidants proteasome calpain caspase-3 reactive oxygen species |
description |
Skeletal muscle is an adaptable tissue that responds rapidly to both increased contractile activity and inactivity. For example, lengthy periods of skeletal muscle disuse (e.g., bed rest) result in a decline of muscle protein and muscular strength. Our understanding of the processes that contribute to disuse muscle atrophy has expanded markedly during the past two decades and this review will provide an overview of the mechanisms responsible for disuse-mediated muscle atrophy. The first segment of this review will outline the experimental models commonly used to investigate disuse muscle atrophy. The second section will discuss our current understanding of muscle proteases whereas the final sector will identify the role that reactive oxygen species play in inactivity-induced muscle atrophy. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S1645-05232008000200011 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S1645-05232008000200011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S1645-05232008000200011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade de Desporto da Universidade do Porto |
publisher.none.fl_str_mv |
Faculdade de Desporto da Universidade do Porto |
dc.source.none.fl_str_mv |
Revista Portuguesa de Ciências do Desporto v.8 n.2 2008 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799137331547996161 |