Interaction of the constituents of alcoholic beverages in the promotion of liver damage.
Autor(a) principal: | |
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Data de Publicação: | 1994 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3028 |
Resumo: | Little has been studied of the adverse effects of the exposure of the liver to the interaction of ethanol with its congeners and acetaldehyde, coexisting in the contents of alcoholic beverages. Twenty four male Wistar rats were divided into four groups. Two groups (SH/DA; SH/FA) were submitted to daily treatment with synthetic hydroalcoholic solutions containing ethanol, methanol, higher alcohols and acetaldehyde in the same proportions as those found in most common distilled and fermented alcoholic beverages; the third group (SH/EA) was treated with a hydroalcoholic solution of ethanol; the fourth group served as control and received an equivalent volume of an isocaloric solution of dextrose. All the animals were killed at the end of the 9th week of the experiment. The ratio between the liver weight and body weight was found to be lower in the treated animals than in the control group. The histology of the liver was altered in the three groups which were submitted to treatment with the hydroalcoholic solutions, with quantitative and qualitative differences between the groups. These results suggest that the hepatoxicity of ethanol in alcoholic beverages is enhanced by interaction with its congeners and acetaldehyde; they also suggest that alcoholic beverages are not equivalent in their potential to cause liver damage. |
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Interaction of the constituents of alcoholic beverages in the promotion of liver damage.Little has been studied of the adverse effects of the exposure of the liver to the interaction of ethanol with its congeners and acetaldehyde, coexisting in the contents of alcoholic beverages. Twenty four male Wistar rats were divided into four groups. Two groups (SH/DA; SH/FA) were submitted to daily treatment with synthetic hydroalcoholic solutions containing ethanol, methanol, higher alcohols and acetaldehyde in the same proportions as those found in most common distilled and fermented alcoholic beverages; the third group (SH/EA) was treated with a hydroalcoholic solution of ethanol; the fourth group served as control and received an equivalent volume of an isocaloric solution of dextrose. All the animals were killed at the end of the 9th week of the experiment. The ratio between the liver weight and body weight was found to be lower in the treated animals than in the control group. The histology of the liver was altered in the three groups which were submitted to treatment with the hydroalcoholic solutions, with quantitative and qualitative differences between the groups. These results suggest that the hepatoxicity of ethanol in alcoholic beverages is enhanced by interaction with its congeners and acetaldehyde; they also suggest that alcoholic beverages are not equivalent in their potential to cause liver damage.Little has been studied of the adverse effects of the exposure of the liver to the interaction of ethanol with its congeners and acetaldehyde, coexisting in the contents of alcoholic beverages. Twenty four male Wistar rats were divided into four groups. Two groups (SH/DA; SH/FA) were submitted to daily treatment with synthetic hydroalcoholic solutions containing ethanol, methanol, higher alcohols and acetaldehyde in the same proportions as those found in most common distilled and fermented alcoholic beverages; the third group (SH/EA) was treated with a hydroalcoholic solution of ethanol; the fourth group served as control and received an equivalent volume of an isocaloric solution of dextrose. All the animals were killed at the end of the 9th week of the experiment. The ratio between the liver weight and body weight was found to be lower in the treated animals than in the control group. The histology of the liver was altered in the three groups which were submitted to treatment with the hydroalcoholic solutions, with quantitative and qualitative differences between the groups. These results suggest that the hepatoxicity of ethanol in alcoholic beverages is enhanced by interaction with its congeners and acetaldehyde; they also suggest that alcoholic beverages are not equivalent in their potential to cause liver damage.Ordem dos Médicos1994-12-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3028oai:ojs.www.actamedicaportuguesa.com:article/3028Acta Médica Portuguesa; Vol. 7 (1994): Suplemento 1; S51-S55Acta Médica Portuguesa; Vol. 7 (1994): Suplemento 1; S51-S551646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3028https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3028/2370Peneda, JorgeBaptista, AméliaLopes, José M.info:eu-repo/semantics/openAccess2022-12-20T11:01:31Zoai:ojs.www.actamedicaportuguesa.com:article/3028Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:18:06.403547Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Interaction of the constituents of alcoholic beverages in the promotion of liver damage. |
title |
Interaction of the constituents of alcoholic beverages in the promotion of liver damage. |
spellingShingle |
Interaction of the constituents of alcoholic beverages in the promotion of liver damage. Peneda, Jorge |
title_short |
Interaction of the constituents of alcoholic beverages in the promotion of liver damage. |
title_full |
Interaction of the constituents of alcoholic beverages in the promotion of liver damage. |
title_fullStr |
Interaction of the constituents of alcoholic beverages in the promotion of liver damage. |
title_full_unstemmed |
Interaction of the constituents of alcoholic beverages in the promotion of liver damage. |
title_sort |
Interaction of the constituents of alcoholic beverages in the promotion of liver damage. |
author |
Peneda, Jorge |
author_facet |
Peneda, Jorge Baptista, Amélia Lopes, José M. |
author_role |
author |
author2 |
Baptista, Amélia Lopes, José M. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Peneda, Jorge Baptista, Amélia Lopes, José M. |
description |
Little has been studied of the adverse effects of the exposure of the liver to the interaction of ethanol with its congeners and acetaldehyde, coexisting in the contents of alcoholic beverages. Twenty four male Wistar rats were divided into four groups. Two groups (SH/DA; SH/FA) were submitted to daily treatment with synthetic hydroalcoholic solutions containing ethanol, methanol, higher alcohols and acetaldehyde in the same proportions as those found in most common distilled and fermented alcoholic beverages; the third group (SH/EA) was treated with a hydroalcoholic solution of ethanol; the fourth group served as control and received an equivalent volume of an isocaloric solution of dextrose. All the animals were killed at the end of the 9th week of the experiment. The ratio between the liver weight and body weight was found to be lower in the treated animals than in the control group. The histology of the liver was altered in the three groups which were submitted to treatment with the hydroalcoholic solutions, with quantitative and qualitative differences between the groups. These results suggest that the hepatoxicity of ethanol in alcoholic beverages is enhanced by interaction with its congeners and acetaldehyde; they also suggest that alcoholic beverages are not equivalent in their potential to cause liver damage. |
publishDate |
1994 |
dc.date.none.fl_str_mv |
1994-12-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3028 oai:ojs.www.actamedicaportuguesa.com:article/3028 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3028 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/3028 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3028 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3028/2370 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 7 (1994): Suplemento 1; S51-S55 Acta Médica Portuguesa; Vol. 7 (1994): Suplemento 1; S51-S55 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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