Unravelling the potential of salivary volatile metabolites in oral diseases. A review

• Autor(a) principal: Pereira, Jorge A. M.
• Data de Publicação: 2020
• Outros Autores: Porto-Figueira, Priscilla, Taware, Ravindra, Sukul, Pritam, Rapole, Srikanth, Câmara, José S.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.13/3869
• topic: Saliva; Volatile organic compounds (VOCs); Oral diseases (ODs);; Biomarkers; Analytical platforms; .; Faculdade de Ciências Exatas e da Engenharia; Centro de Química da Madeira

Fostered by the advances in the instrumental and analytical fields, in recent years the analysis of volatile organic compounds (VOCs) has emerged as a new frontier in medical diagnostics. VOCs analysis is a non-invasive, rapid and inexpensive strategy with promising potential in clinical diagnostic procedures. Since cellular metabolism is altered by diseases, the resulting metabolic effects on VOCs may serve as biomarkers for any given pathophysiologic condition. Human VOCs are released from biomatrices such as saliva, urine, skin emanations and exhaled breath and are derived from many metabolic pathways. In this review, the potential of VOCs present in saliva will be explored as a monitoring tool for several oral diseases, including gingivitis and periodontal disease, dental caries, and oral cancer. Moreover, the analytical state-of-the-art for salivary volatomics, e.g., the most common extraction techniques along with the current challenges and future perspectives will be addressed unequivocally