Epigenetics and behavioural plasticity: drosophila euchromatin histone metiltransferase and foraging

Detalhes bibliográficos
Autor(a) principal: Anreiter, Ina
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/8144
Resumo: A thesis submitted in fulfillment of the requirements for the degree of Masters in Molecular Genetics and Biomedicine
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spelling Epigenetics and behavioural plasticity: drosophila euchromatin histone metiltransferase and foragingBehaviourPlasticityEpigenetic regulationForagingEHMTA thesis submitted in fulfillment of the requirements for the degree of Masters in Molecular Genetics and BiomedicineThe foraging gene in D. melanogaster underlies a natural polymorphism with two variants called rover and sitter. These variants differ in a suite of phenotypes which are plastic when exposed to varying environmental parameters. Although the phenotypic differences between rovers and sitters are evident, the underlying molecular mechanisms involved are not completely understood. Recently, a histone methyltransferase (EHMT) was found to methylate histones at the foraging promoter region, suggesting a possible interaction of these two genes. This work provides strong evidence that EHMT significantly affects several phenotypic traits linked to the foraging gene. EHMT is needed for the plastic response to food-deprivation seen in larval feeding behaviour, evident as food-deprived larvae lacking EHMT show the same behaviour as fed larva, while larva with functional EHMT significantly reduce their path-lengths when food-deprived. Furthermore, the loss of functional EHMT affects sitter but not rover adult foraging behaviour in food-deprived flies, suggesting an epigenetic interaction between EHMT and the foraging alleles. EHMT mutants also have higher fat storage levels and survive longer during starvation. And finally, EHMT mutants and revertants do not differ significantly in overall foraging RNA expression in fed and food-deprived feeding regimes, but show substantial differences in the foraging protein isoforms expressed. Taken together, this thesis provides proof that EHMT epigenetically regulates traits influenced by the foraging gene and that this regulation is linked to environmental cues. Considering that both foraging and EHMT have homologues in many species and have been associated to a series of human diseases, the results herein are also interesting from a human perspective.Faculdade de Ciências e TecnologiaSokolowski, MarlaPereira, SofiaRUNAnreiter, Ina2012-11-15T15:54:53Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/8144enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T03:40:37Zoai:run.unl.pt:10362/8144Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:17:58.462095Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Epigenetics and behavioural plasticity: drosophila euchromatin histone metiltransferase and foraging
title Epigenetics and behavioural plasticity: drosophila euchromatin histone metiltransferase and foraging
spellingShingle Epigenetics and behavioural plasticity: drosophila euchromatin histone metiltransferase and foraging
Anreiter, Ina
Behaviour
Plasticity
Epigenetic regulation
Foraging
EHMT
title_short Epigenetics and behavioural plasticity: drosophila euchromatin histone metiltransferase and foraging
title_full Epigenetics and behavioural plasticity: drosophila euchromatin histone metiltransferase and foraging
title_fullStr Epigenetics and behavioural plasticity: drosophila euchromatin histone metiltransferase and foraging
title_full_unstemmed Epigenetics and behavioural plasticity: drosophila euchromatin histone metiltransferase and foraging
title_sort Epigenetics and behavioural plasticity: drosophila euchromatin histone metiltransferase and foraging
author Anreiter, Ina
author_facet Anreiter, Ina
author_role author
dc.contributor.none.fl_str_mv Sokolowski, Marla
Pereira, Sofia
RUN
dc.contributor.author.fl_str_mv Anreiter, Ina
dc.subject.por.fl_str_mv Behaviour
Plasticity
Epigenetic regulation
Foraging
EHMT
topic Behaviour
Plasticity
Epigenetic regulation
Foraging
EHMT
description A thesis submitted in fulfillment of the requirements for the degree of Masters in Molecular Genetics and Biomedicine
publishDate 2012
dc.date.none.fl_str_mv 2012-11-15T15:54:53Z
2012
2012-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/8144
url http://hdl.handle.net/10362/8144
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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