Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures

Detalhes bibliográficos
Autor(a) principal: De Mello-Sampayo, C.
Data de Publicação: 2017
Outros Autores: Agripino, A.A., Stilwell, D., Vidal, B., Fernando, Ana Luisa, Silva-Lima, B., Vaz, M.F., Canhão, Helena, Marques, Maria Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1155/2017/4603247
Resumo: The authors thank Cintramedica, Laboratorio de analises clinicas, Sintra, Portugal, for the assistance in biomarker analyses. This research has been partially financially supported with Grant UID/EMS/50022/2013, sponsored by the Portuguese Foundation for the Science and Technology ("Fundacao para a Ciencia e a Tecnologia"-FCT).
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spelling Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile StructuresSDG 3 - Good Health and Well-beingThe authors thank Cintramedica, Laboratorio de analises clinicas, Sintra, Portugal, for the assistance in biomarker analyses. This research has been partially financially supported with Grant UID/EMS/50022/2013, sponsored by the Portuguese Foundation for the Science and Technology ("Fundacao para a Ciencia e a Tecnologia"-FCT).There is controversy concerning the diabetes impact on bone quality, notorious in type 2 diabetic postmenopausal women. One pointed cause might be uncontrolled glycemia. In this study, the effect of chronic hyperglycemia in bone turnover, morphology, and biomechanics was evaluated in female Wistar rats in the presence/absence of estrogens (ovariectomy). Animals (n=28) were divided into sham, ovariectomized (OVX), hyperglycemic (streptozotocin 40 mg/kg, single-dose i.p.-STZ), and hyperglycemic-ovariectomized (STZ + OVX) animals. Blood biomarkers were estimated 60 days postovariectomy. Body weight, vertebral microarchitecture (L4-histomorphometry), femur biomechanical properties (bending tests), tibia ultrastructure (scanning electron microscopy), and femur and urinary calcium (atomic absorption) were also evaluated. The increased PINP/CTX ratio of hyperglycemic animals and the similar ratio between STZ + OVX and healthy animals contrasting with the lower ratio of OVX (in line with its histomorphometric data) suggest a tendency for improved bone formation in hyperglycemic-ovariectomized animals. The increased tibia medullar canal, which contrasts with the unaffected cortical thickness of both hyperglycemic groups while that of OVX decreased, was associated to the increased stiffness and strength of STZ + OVX bones compared to those of OVX, in line with the observed ultrastructure. Concluding, chronic hyperglycemia in ovariectomized female rats causes bone morphological changes that translate positively in the ultrastructure and mechanical properties of cortical bones. © 2017 Cristina de Mello-Sampayo et al.DCTB - Departamento de Ciências e Tecnologia da Biomassa (ex-GDEH)MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de RecursosUBIA - Unidade de Biotecnologia AmbientalNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Escola Nacional de Saúde Pública (ENSP)RUNDe Mello-Sampayo, C.Agripino, A.A.Stilwell, D.Vidal, B.Fernando, Ana LuisaSilva-Lima, B.Vaz, M.F.Canhão, HelenaMarques, Maria Cristina2017-10-20T22:03:06Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1155/2017/4603247eng1687-8337PURE: 3226051https://www.hindawi.com/journals/ije/2017/4603247/https://doi.org/10.1155/2017/4603247info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:12:38Zoai:run.unl.pt:10362/24379Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:28:02.315016Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures
title Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures
spellingShingle Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures
De Mello-Sampayo, C.
SDG 3 - Good Health and Well-being
title_short Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures
title_full Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures
title_fullStr Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures
title_full_unstemmed Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures
title_sort Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures
author De Mello-Sampayo, C.
author_facet De Mello-Sampayo, C.
Agripino, A.A.
Stilwell, D.
Vidal, B.
Fernando, Ana Luisa
Silva-Lima, B.
Vaz, M.F.
Canhão, Helena
Marques, Maria Cristina
author_role author
author2 Agripino, A.A.
Stilwell, D.
Vidal, B.
Fernando, Ana Luisa
Silva-Lima, B.
Vaz, M.F.
Canhão, Helena
Marques, Maria Cristina
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DCTB - Departamento de Ciências e Tecnologia da Biomassa (ex-GDEH)
MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de Recursos
UBIA - Unidade de Biotecnologia Ambiental
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Escola Nacional de Saúde Pública (ENSP)
RUN
dc.contributor.author.fl_str_mv De Mello-Sampayo, C.
Agripino, A.A.
Stilwell, D.
Vidal, B.
Fernando, Ana Luisa
Silva-Lima, B.
Vaz, M.F.
Canhão, Helena
Marques, Maria Cristina
dc.subject.por.fl_str_mv SDG 3 - Good Health and Well-being
topic SDG 3 - Good Health and Well-being
description The authors thank Cintramedica, Laboratorio de analises clinicas, Sintra, Portugal, for the assistance in biomarker analyses. This research has been partially financially supported with Grant UID/EMS/50022/2013, sponsored by the Portuguese Foundation for the Science and Technology ("Fundacao para a Ciencia e a Tecnologia"-FCT).
publishDate 2017
dc.date.none.fl_str_mv 2017-10-20T22:03:06Z
2017
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1155/2017/4603247
url https://doi.org/10.1155/2017/4603247
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1687-8337
PURE: 3226051
https://www.hindawi.com/journals/ije/2017/4603247/
https://doi.org/10.1155/2017/4603247
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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