Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.10/2435 |
Resumo: | Alpha-1 antitrypsin deficiency (AATD) is a cause of bronchiectasis. Guidelines for bronchiectasis from the British Thoracic Society do not recommend to routinely test patients for AATD. In contrast, guidelines for AATD recommend routine screening. This contradiction, in part, results from the lack of data from large studies performing comprehensive screening. We screened 1600 patients with bronchiectasis at two centres in the UK from 2012 to 2016. In total, only eight individuals with AATD were identified representing 0.5% of the overall population. We conclude that routine screening for AATD in bronchiectasis in the UK has a low rate of detection. Further studies are required in different geographical regions, which may have a higher prevalence of AATD. |
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Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasisBronchiectasisAlpha 1-Antitrypsin deficiencyAlpha-1 antitrypsin deficiency (AATD) is a cause of bronchiectasis. Guidelines for bronchiectasis from the British Thoracic Society do not recommend to routinely test patients for AATD. In contrast, guidelines for AATD recommend routine screening. This contradiction, in part, results from the lack of data from large studies performing comprehensive screening. We screened 1600 patients with bronchiectasis at two centres in the UK from 2012 to 2016. In total, only eight individuals with AATD were identified representing 0.5% of the overall population. We conclude that routine screening for AATD in bronchiectasis in the UK has a low rate of detection. Further studies are required in different geographical regions, which may have a higher prevalence of AATD.British Medical AssociationRepositório do Hospital Prof. Doutor Fernando FonsecaCarreto, LMorrison, MDonovan, JFinch, STan, GLFardon, T, et al.2020-07-01T15:07:38Z2020-01-01T00:00:00Z2020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.10/2435engThorax. 2020 Jul;75(7):592-5931468-329610.1136/thoraxjnl-2019-214195info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-20T15:53:06Zoai:repositorio.hff.min-saude.pt:10400.10/2435Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:53:21.495321Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis |
title |
Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis |
spellingShingle |
Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis Carreto, L Bronchiectasis Alpha 1-Antitrypsin deficiency |
title_short |
Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis |
title_full |
Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis |
title_fullStr |
Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis |
title_full_unstemmed |
Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis |
title_sort |
Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis |
author |
Carreto, L |
author_facet |
Carreto, L Morrison, M Donovan, J Finch, S Tan, GL Fardon, T, et al. |
author_role |
author |
author2 |
Morrison, M Donovan, J Finch, S Tan, GL Fardon, T, et al. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Hospital Prof. Doutor Fernando Fonseca |
dc.contributor.author.fl_str_mv |
Carreto, L Morrison, M Donovan, J Finch, S Tan, GL Fardon, T, et al. |
dc.subject.por.fl_str_mv |
Bronchiectasis Alpha 1-Antitrypsin deficiency |
topic |
Bronchiectasis Alpha 1-Antitrypsin deficiency |
description |
Alpha-1 antitrypsin deficiency (AATD) is a cause of bronchiectasis. Guidelines for bronchiectasis from the British Thoracic Society do not recommend to routinely test patients for AATD. In contrast, guidelines for AATD recommend routine screening. This contradiction, in part, results from the lack of data from large studies performing comprehensive screening. We screened 1600 patients with bronchiectasis at two centres in the UK from 2012 to 2016. In total, only eight individuals with AATD were identified representing 0.5% of the overall population. We conclude that routine screening for AATD in bronchiectasis in the UK has a low rate of detection. Further studies are required in different geographical regions, which may have a higher prevalence of AATD. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-07-01T15:07:38Z 2020-01-01T00:00:00Z 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.10/2435 |
url |
http://hdl.handle.net/10400.10/2435 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Thorax. 2020 Jul;75(7):592-593 1468-3296 10.1136/thoraxjnl-2019-214195 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
British Medical Association |
publisher.none.fl_str_mv |
British Medical Association |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130400580173824 |