Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis

Detalhes bibliográficos
Autor(a) principal: Carreto, L
Data de Publicação: 2020
Outros Autores: Morrison, M, Donovan, J, Finch, S, Tan, GL, Fardon, T, et al.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.10/2435
Resumo: Alpha-1 antitrypsin deficiency (AATD) is a cause of bronchiectasis. Guidelines for bronchiectasis from the British Thoracic Society do not recommend to routinely test patients for AATD. In contrast, guidelines for AATD recommend routine screening. This contradiction, in part, results from the lack of data from large studies performing comprehensive screening. We screened 1600 patients with bronchiectasis at two centres in the UK from 2012 to 2016. In total, only eight individuals with AATD were identified representing 0.5% of the overall population. We conclude that routine screening for AATD in bronchiectasis in the UK has a low rate of detection. Further studies are required in different geographical regions, which may have a higher prevalence of AATD.
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spelling Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasisBronchiectasisAlpha 1-Antitrypsin deficiencyAlpha-1 antitrypsin deficiency (AATD) is a cause of bronchiectasis. Guidelines for bronchiectasis from the British Thoracic Society do not recommend to routinely test patients for AATD. In contrast, guidelines for AATD recommend routine screening. This contradiction, in part, results from the lack of data from large studies performing comprehensive screening. We screened 1600 patients with bronchiectasis at two centres in the UK from 2012 to 2016. In total, only eight individuals with AATD were identified representing 0.5% of the overall population. We conclude that routine screening for AATD in bronchiectasis in the UK has a low rate of detection. Further studies are required in different geographical regions, which may have a higher prevalence of AATD.British Medical AssociationRepositório do Hospital Prof. Doutor Fernando FonsecaCarreto, LMorrison, MDonovan, JFinch, STan, GLFardon, T, et al.2020-07-01T15:07:38Z2020-01-01T00:00:00Z2020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.10/2435engThorax. 2020 Jul;75(7):592-5931468-329610.1136/thoraxjnl-2019-214195info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-20T15:53:06Zoai:repositorio.hff.min-saude.pt:10400.10/2435Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:53:21.495321Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis
title Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis
spellingShingle Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis
Carreto, L
Bronchiectasis
Alpha 1-Antitrypsin deficiency
title_short Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis
title_full Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis
title_fullStr Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis
title_full_unstemmed Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis
title_sort Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis
author Carreto, L
author_facet Carreto, L
Morrison, M
Donovan, J
Finch, S
Tan, GL
Fardon, T, et al.
author_role author
author2 Morrison, M
Donovan, J
Finch, S
Tan, GL
Fardon, T, et al.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Hospital Prof. Doutor Fernando Fonseca
dc.contributor.author.fl_str_mv Carreto, L
Morrison, M
Donovan, J
Finch, S
Tan, GL
Fardon, T, et al.
dc.subject.por.fl_str_mv Bronchiectasis
Alpha 1-Antitrypsin deficiency
topic Bronchiectasis
Alpha 1-Antitrypsin deficiency
description Alpha-1 antitrypsin deficiency (AATD) is a cause of bronchiectasis. Guidelines for bronchiectasis from the British Thoracic Society do not recommend to routinely test patients for AATD. In contrast, guidelines for AATD recommend routine screening. This contradiction, in part, results from the lack of data from large studies performing comprehensive screening. We screened 1600 patients with bronchiectasis at two centres in the UK from 2012 to 2016. In total, only eight individuals with AATD were identified representing 0.5% of the overall population. We conclude that routine screening for AATD in bronchiectasis in the UK has a low rate of detection. Further studies are required in different geographical regions, which may have a higher prevalence of AATD.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-01T15:07:38Z
2020-01-01T00:00:00Z
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.10/2435
url http://hdl.handle.net/10400.10/2435
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Thorax. 2020 Jul;75(7):592-593
1468-3296
10.1136/thoraxjnl-2019-214195
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv British Medical Association
publisher.none.fl_str_mv British Medical Association
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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